SSR4

SSR4
Identifiers
Aliases	SSR4 , TRAPD, CDG1Y, signal sequence receptor subunit 4
External IDs	OMIM: 300090 MGI: 1099464 HomoloGene: 4573 GeneCards: SSR4
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 153,793,516 bp [1] End 153,798,499 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X A7.3|X 37.41 cM Start 72,830,634 bp [2] End 72,834,436 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary body of pancreas seminal vesicula trachea pylorus minor salivary gland corpus epididymis Stromal cell of endometrium body of stomach Top expressed in seminal vesicula parotid gland islet of Langerhans submandibular gland molar lacrimal gland cervix calvaria crypt of lieberkuhn of small intestine stomach More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 6748 20832 Ensembl ENSG00000180879 ENSMUSG00000002014 UniProt P51571 Q62186 RefSeq (mRNA) NM_001204526 NM_001204527 NM_006280 NM_001166480 NM_009279 NM_001358212 NM_001358213 RefSeq (protein) NP_001191455 NP_001191456 NP_006271 NP_001159952 NP_033305 NP_001345141 NP_001345142 Location (UCSC) Chr X: 153.79 – 153.8 Mb Chr X: 72.83 – 72.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Translocon-associated protein subunit delta is a protein that in humans is encoded by the SSR4 gene. ^{[5] [6]}

SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric length from the ALD gene. Although alternative splicing of exon 5 has not been detected in the human SSR4 gene, transcript variants missing the region homologous to the human exon 5 have been detected in both Xenopus laevis and Mus musculus . ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000180879 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002014 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brenner V, Nyakatura G, Rosenthal A, Platzer M (Nov 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID   9286695.
6. "Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)".

Further reading

• Holthuis JC, van Riel MC, Martens GJ (1996). "Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary". Biochem. J. 312 ( Pt 1) (Pt 1): 205–13. doi:10.1042/bj3120205. PMC   1136246 . PMID   7492314.
• Hartmann E, Görlich D, Kostka S, et al. (1993). "A tetrameric complex of membrane proteins in the endoplasmic reticulum". Eur. J. Biochem. 214 (2): 375–81. doi:10.1111/j.1432-1033.1993.tb17933.x. hdl: 11858/00-001M-0000-0015-3BD2-F . PMID   7916687.
• Wang L, Dobberstein B (1999). "Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum". FEBS Lett. 457 (3): 316–22. doi: 10.1016/S0014-5793(99)01075-3 . PMID   10471800.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Miyazaki K, Fujita T, Ozaki T, et al. (2004). "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1". J. Biol. Chem. 279 (12): 11327–35. doi: 10.1074/jbc.M312389200 . PMID   14684739.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Wang Z, VandeBerg JL (2005). "Cloning and molecular characterization of a human ortholog of Monodelphis TRAPD in ultraviolet B-induced melanoma". Melanoma Res. 14 (2): 107–14. doi:10.1097/00008390-200404000-00005. PMID   15057039. S2CID   12281868.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.