SSR4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | SSR4 , TRAPD, CDG1Y, signal sequence receptor subunit 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 300090 MGI: 1099464 HomoloGene: 4573 GeneCards: SSR4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Translocon-associated protein subunit delta is a protein that in humans is encoded by the SSR4 gene. [5] [6]
SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric length from the ALD gene. Although alternative splicing of exon 5 has not been detected in the human SSR4 gene, transcript variants missing the region homologous to the human exon 5 have been detected in both Xenopus laevis and Mus musculus . [6]
B-cell receptor-associated protein 31 is a protein that in humans is encoded by the BCAP31 gene.
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating is an enzyme that in humans is encoded by the NSDHL gene. This enzyme is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis.
DnaJ homolog subfamily B member 11 is a protein that in humans is encoded by the DNAJB11 gene.
DnaJ homolog subfamily B member 9 is a protein that in humans is encoded by the DNAJB9 gene.
Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.
Ribosome-binding protein 1, also referred to as p180, is a protein that in humans is encoded by the RRBP1 gene.
Translocon-associated protein subunit beta also known as TRAP-beta is a protein that in humans is encoded by the SSR2 gene.
Transmembrane protein 50A is a protein that in humans is encoded by the TMEM50A gene.
Multiple inositol polyphosphate phosphatase 1 is an enzyme that in humans is encoded by the MINPP1 gene.
Protein O-mannosyl-transferase 2 is an enzyme that in humans is encoded by the POMT2 gene.
Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.
Dehydrogenase/reductase SDR family member 1, also known as Short chain dehydrogenase/reductase family 19C member 1 is an enzyme that in humans is encoded by the DHRS1 gene located on chromosome 14.
Stress-associated endoplasmic reticulum protein 1 is a protein that in humans is encoded by the SERP1 gene.
Protein FAM50A is a protein that in humans is encoded by the FAM50A gene.
Translocating chain-associated membrane protein 2 is a protein that in humans is encoded by the TRAM2 gene.
Vesicle-trafficking protein SEC22a is a protein that in humans is encoded by the SEC22A gene.
Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.
Protein disulfide-isomerase TMX3 is an enzyme that in humans is encoded by the TMX3 gene.
FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene.
P3 protein is a protein that in humans is encoded by the SLC10A3 gene.