ST8:USA300

Last updated
Staphylococcus aureus ST8:USA300
MRSA7820.jpg
Electron micrograph of MRSA
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Kingdom: Bacillati
Phylum: Bacillota
Class: Bacilli
Order: Bacillales
Family: Staphylococcaceae
Genus: Staphylococcus
Species: S. aureus
Strain:S. a. ST8:USA300
Trionomial name
Staphylococcus aureus ST8:USA300

ST8:USA300 is a strain of community-associated methicillin-resistant Staphylococcus aureus (MRSA) that has emerged as a particularly antibiotic resistant epidemic that is responsible for rapidly progressive, fatal diseases including necrotizing pneumonia, severe sepsis and necrotizing fasciitis. [1]

The epidemiology of infections caused by MRSA is rapidly changing: in the past 10 years, infections caused by this organism have emerged in the community (whereas previously MRSA infections were almost exclusively hospital-acquired). The two MRSA clones in the United States most closely associated with community outbreaks, USA400 (MW2 strain, ST1 lineage) and USA300, often contain Panton-Valentine leukocidin (PVL) genes and, more frequently, have been associated with skin and soft tissue infections.

Outbreaks of community-associated (CA)-MRSA infections have been reported in correctional facilities, among athletic teams, among military recruits, in newborn nurseries, and among sexually active men who have sex with men, CA-MRSA infections now appear to be endemic in many urban regions and cause most MRSA infections. [2] [3]

References

  1. Boyle-Vavra S, Daum RS (2007). "Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin". Lab. Invest. 87 (1): 3–9. doi: 10.1038/labinvest.3700501 . PMID   17146447.
  2. Maree CL, Daum RS, Boyle-Vavra S, Matayoshi K, Miller LG (2007). "Community-associated methicillin-resistant Staphylococcus aureus isolates causing healthcare-associated infections". Emerging Infect. Dis. 13 (2): 236–42. doi:10.3201/eid1302.060781. PMC   2725868 . PMID   17479885.
  3. Diep BA, Chambers HF, Graber CJ, et al. (February 2008). "Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men". Ann. Intern. Med. 148 (4): 249–57. doi:10.7326/0003-4819-148-4-200802190-00204. PMID   18283202. S2CID   20491386.