Stabilin-2 is a protein that in humans is encoded by the STAB2 gene. [5] [6] [7]
Stabilin-2 is a protein that in humans is encoded by the STAB2 gene. [5] [6] [7]
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on liver sinusoidal endothelial cells, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [7]
Glycosaminoglycans (GAGs) or mucopolysaccharides are long linear polysaccharides consisting of repeating disaccharide units. The repeating two-sugar unit consists of a uronic sugar and an amino sugar, with the exception of keratan, where in the place of the uronic sugar it has galactose. Because GAGs are highly polar and attract water, they are used in the body as a lubricant or shock absorber.
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands.
Amphiphysin is a protein that in humans is encoded by the AMPH gene.
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene.
Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.
AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.
Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.
AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.
AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.
Galectin-8 is a protein of the galectin family that in humans is encoded by the LGALS8 gene.
Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.
Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene and is involved in clathrin mediated endocytosis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. SIGLEC7 has also been designated as CD328.
Hyaluronan synthase 1 is an enzyme that in humans is encoded by the HAS1 gene.
Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.
Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene.
Tumor necrosis factor-inducible gene 6 protein also known as TNF-stimulated gene 6 protein or TSG-6 is a protein that in humans is encoded by the TNFAIP6 gene.
RalBP1-associated Eps domain-containing protein 2 is a protein that in humans is encoded by the REPS2 gene.
Carbohydrate sulfotransferase 5 is an enzyme that in humans is encoded by the CHST5 gene.
 | This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it. |