STAM2

STAM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X2Q, 1X5B, 2L0T, 5CRV
Identifiers
Aliases	STAM2 , Hbp, STAM2A, STAM2B, signal transducing adaptor molecule 2
External IDs	OMIM: 606244; MGI: 1929100; HomoloGene: 68490; GeneCards: STAM2; OMA:STAM2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q23.3 Start 152,116,801 bp [1] End 152,175,763 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 C1.1 Start 52,581,676 bp [2] End 52,632,293 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii Achilles tendon mucosa of paranasal sinus bronchial epithelial cell epithelium of nasopharynx internal globus pallidus oocyte buccal mucosa cell superficial temporal artery secondary oocyte Top expressed in spermatid spermatocyte morula morula pineal gland median eminence epithelium of stomach habenula neural layer of retina seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm ESCRT-0 complex endosome early endosome membrane intracellular membrane-bounded organelle membrane nucleoplasm cytosol Biological process protein transport endosomal transport multivesicular body assembly intracellular protein transport negative regulation of epidermal growth factor receptor signaling pathway macroautophagy membrane organization protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10254 56324 Ensembl ENSG00000115145 ENSMUSG00000055371 UniProt O75886 O88811 RefSeq (mRNA) NM_005843 NM_019667 RefSeq (protein) NP_005834 NP_062641 Location (UCSC) Chr 2: 152.12 – 152.18 Mb Chr 2: 52.58 – 52.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. ^[7]

Interactions

STAM2 has been shown to interact with HGS, ^{[8] [9]} Janus kinase 1 ^{[5] [6]} and USP8. ^{[10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000115145 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055371 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K (Jul 2000). "STAM2, a new member of the STAM family, binding to the Janus kinases". FEBS Letters. 477 (1–2): 55–61. doi: 10.1016/S0014-5793(00)01760-9 . PMID   10899310. S2CID   31811757.
6. Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF (Dec 2000). "Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways". The Journal of Biological Chemistry. 275 (49): 38633–9. doi: 10.1074/jbc.M007849200 . PMID   10993906.
7. "Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2".
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
9. Bache KG, Raiborg C, Mehlum A, Stenmark H (Apr 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". The Journal of Biological Chemistry. 278 (14): 12513–21. doi: 10.1074/jbc.M210843200 . PMID   12551915.
10. Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (Nov 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi: 10.1074/jbc.M306677200 . PMID   13129930.
11. Kato M, Miyazawa K, Kitamura N (Dec 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi: 10.1074/jbc.M007251200 . PMID   10982817.

Further reading

• Sulman EP, Tang XX, Allen C, Biegel JA, Pleasure DE, Brodeur GM, Ikegaki N (Mar 1997). "ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers". Genomics. 40 (2): 371–4. doi: 10.1006/geno.1996.4569 . PMID   9119409.
• Kato M, Miyazawa K, Kitamura N (Dec 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi: 10.1074/jbc.M007251200 . PMID   10982817.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Steen H, Kuster B, Fernandez M, Pandey A, Mann M (Jan 2002). "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway". The Journal of Biological Chemistry. 277 (2): 1031–9. doi: 10.1074/jbc.M109992200 . PMID   11687594.
• Bache KG, Raiborg C, Mehlum A, Stenmark H (Apr 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". The Journal of Biological Chemistry. 278 (14): 12513–21. doi: 10.1074/jbc.M210843200 . PMID   12551915.
• Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (Nov 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi: 10.1074/jbc.M306677200 . PMID   13129930.
• Mizuno E, Kawahata K, Okamoto A, Kitamura N, Komada M (Mar 2004). "Association with Hrs is required for the early endosomal localization, stability, and function of STAM". Journal of Biochemistry. 135 (3): 385–96. doi:10.1093/jb/mvh046. PMID   15113837.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Lechner MS, Schultz DC, Negorev D, Maul GG, Rauscher FJ (Jun 2005). "The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain". Biochemical and Biophysical Research Communications. 331 (4): 929–37. doi:10.1016/j.bbrc.2005.04.016. PMID   15882967.

External links

• STAM2 human gene location in the UCSC Genome Browser .
• STAM2 human gene details in the UCSC Genome Browser .