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| Aliases | STAM2 , Hbp, STAM2A, STAM2B, signal transducing adaptor molecule 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606244 MGI: 1929100 HomoloGene: 68490 GeneCards: STAM2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene. [5] [6] [7]
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [7]
STAM2 has been shown to interact with HGS, [8] [9] Janus kinase 1 [5] [6] and USP8. [10] [11]
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins. Receptor tyrosine kinases have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Mutations in receptor tyrosine kinases lead to activation of a series of signalling cascades which have numerous effects on protein expression. Receptor tyrosine kinases are part of the larger family of protein tyrosine kinases, encompassing the receptor tyrosine kinase proteins which contain a transmembrane domain, as well as the non-receptor tyrosine kinases which do not possess transmembrane domains.
Crk-like protein is a protein that in humans is encoded by the CRKL gene.
Interleukin enhancer-binding factor 3 is a protein that in humans is encoded by the ILF3 gene.
Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.
Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is a signal transduction enzyme that in humans is encoded by the autosomal MAP3K1 gene.
Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.
The B-cell linker protein is encoded by the BLNK gene and is an adaptor protein also known as SLP-65, BASH, and BCA. BLNK is expressed in B cells and macrophages and plays a large role in B cell receptor signalling, in a fashion analogous to the role its paralogue SLP-76 plays in T cell receptor signalling. As it has no known intrinsic enzymatic activity, the function of BLNK is to temporally and spatially coordinate and regulate signalling effectors downstream of the B cell receptor.
LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.
Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene.
STAM-binding protein is a protein that in humans is encoded by the STAMBP gene.
ArgBP2 protein, also referred to as Sorbin and SH3 domain-containing protein 2 is a protein that in humans is encoded by the SORBS2 gene. ArgBP2 belongs to the a small family of adaptor proteins having sorbin homology (SOHO) domains. ArgBP2 is highly abundant in cardiac muscle cells at sarcomeric Z-disc structures, and is expressed in other cells at actin stress fibers and the nucleus.
Transcriptional adapter 3-like is a protein that in humans is encoded by the TADA3 gene. Cytogenetic location: 3p25.3
Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.
Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.
SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.
Myelin protein zero-like protein 1 is a protein that in humans is encoded by the MPZL1 gene.
Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene.
Synaptojanin-2-binding protein is a protein that in humans is encoded by the SYNJ2BP gene.
Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.
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