USP8

Last updated
USP8
Protein USP8 PDB 1whb.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases USP8 , HumORF8, SPG59, UBPY, ubiquitin specific peptidase 8, PITA4
External IDs OMIM: 603158; MGI: 1934029; HomoloGene: 3782; GeneCards: USP8; OMA:USP8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001128610
NM_001128611
NM_001283049
NM_005154

NM_001252580
NM_019729

RefSeq (protein)

NP_001122082
NP_001269978
NP_005145

NP_001239509
NP_062703

Location (UCSC) Chr 15: 50.42 – 50.51 Mb Chr 2: 126.55 – 126.6 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene. [5] [6] [7]

Contents

Interactions

USP8 has been shown to interact with RNF41 [8] and STAM2. [9] [10]

Diseases

In a few cases of Morbus Cushing's disease, a mutation of USP8 has been found.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138592 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027363 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–58. doi:10.1038/nrg1111. PMID   12838346. S2CID   2856065.
  6. Janssen JW, Schleithoff L, Bartram CR, Schulz AS (April 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. doi: 10.1038/sj.onc.1201695 . PMID   9582025.
  7. "Entrez Gene: USP8 ubiquitin specific peptidase 8".
  8. Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Molecular and Cellular Biology. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC   506982 . PMID   15314180.
  9. Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi: 10.1074/jbc.M306677200 . PMID   13129930.
  10. Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi: 10.1074/jbc.M007251200 . PMID   10982817.

Further reading