STMN2

STMN2
Identifiers
Aliases	STMN2 , SCG10, SCGN10, stathmin 2
External IDs	OMIM: 600621; MGI: 98241; HomoloGene: 5102; GeneCards: STMN2; OMA:STMN2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q21.13 Start 79,611,117 bp [1] End 79,666,158 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 A1|3 2.15 cM Start 8,574,420 bp [2] End 8,626,666 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons cerebellar vermis spinal ganglia lateral nuclear group of thalamus ganglionic eminence pars compacta superior vestibular nucleus frontal pole cerebellar hemisphere paraflocculus of cerebellum Top expressed in superior cervical ganglion barrel cortex anterior horn of spinal cord lobe of cerebellum medial dorsal nucleus facial motor nucleus cerebellar vermis cingulate gyrus medulla oblongata dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-dependent protein binding tubulin binding protein binding Cellular component cytoplasm vesicle endosome Golgi apparatus cell projection membrane growth cone axon soma perinuclear region of cytoplasm neuron projection lamellipodium Biological process cellular response to nerve growth factor stimulus negative regulation of neuron projection development negative regulation of microtubule polymerization negative regulation of microtubule depolymerization regulation of microtubule polymerization or depolymerization positive regulation of neuron projection development positive regulation of microtubule depolymerization microtubule depolymerization neuron projection development regulation of cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11075 20257 Ensembl ENSG00000104435 ENSMUSG00000027500 UniProt Q93045 P55821 RefSeq (mRNA) NM_001199214 NM_007029 NM_025285 RefSeq (protein) NP_001186143 NP_008960 NP_079561 Location (UCSC) Chr 8: 79.61 – 79.67 Mb Chr 3: 8.57 – 8.63 Mb PubMed search [3] [4]
Wikidata
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Stathmin-2 is a protein that in humans is encoded by the STMN2 gene. ^{[5] [6] [7]}

Function

Superior cervical ganglion-10 is a neuronal growth-associated protein which shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).[supplied by OMIM] ^[7]

Interactions

STMN2 has been shown to interact with RGS6. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000104435 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027500 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Okazaki T, Wang H, Masliah E, Cao M, Johnson SA, Sundsmo M, Saitoh T, Mori N (June 1996). "SCG10, a neuron-specific growth-associated protein in Alzheimer's disease". Neurobiology of Aging. 16 (6): 883–94. doi:10.1016/0197-4580(95)02001-2. PMID   8622778. S2CID   54320124.
6. Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". The Journal of Biological Chemistry. 277 (40): 37832–9. doi: 10.1074/jbc.M205908200 . PMID   12140291.
7. "Entrez Gene: STMN2 stathmin-like 2".

Further reading

• Di Paolo G, Lutjens R, Pellier V, Stimpson SA, Beuchat MH, Catsicas S, Grenningloh G (February 1997). "Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region". The Journal of Biological Chemistry. 272 (8): 5175–82. doi: 10.1074/jbc.272.8.5175 . PMID   9030585.
• Antonsson B, Lütjens R, Di Paolo G, Kassel D, Allet B, Bernard A, Catsicas S, Grenningloh G (April 1997). "Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10". Protein Expression and Purification. 9 (3): 363–71. doi:10.1006/prep.1996.0710. PMID   9126608.
• Antonsson B, Kassel DB, Di Paolo G, Lutjens R, Riederer BM, Grenningloh G (April 1998). "Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity". The Journal of Biological Chemistry. 273 (14): 8439–46. doi: 10.1074/jbc.273.14.8439 . PMID   9525956.
• Lutjens R, Igarashi M, Pellier V, Blasey H, Di Paolo G, Ruchti E, Pfulg C, Staple JK, Catsicas S, Grenningloh G (July 2000). "Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles". The European Journal of Neuroscience. 12 (7): 2224–34. doi:10.1046/j.1460-9568.2000.00112.x. PMID   10947801. S2CID   41593815.
• Neidhart S, Antonsson B, Gilliéron C, Vilbois F, Grenningloh G, Arkinstall S (November 2001). "c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10". FEBS Letters. 508 (2): 259–64. doi:10.1016/S0014-5793(01)03090-3. PMID   11718727. S2CID   84253949.
• Nixon AB, Grenningloh G, Casey PJ (May 2002). "The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly". The Journal of Biological Chemistry. 277 (20): 18127–33. doi: 10.1074/jbc.M201065200 . PMID   11882662.
• Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nature Neuroscience. 6 (8): 837–45. doi:10.1038/nn1092. PMID   12858178. S2CID   7523946.
• Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage FH (March 2004). "A small modulatory dsRNA specifies the fate of adult neural stem cells". Cell. 116 (6): 779–93. doi: 10.1016/S0092-8674(04)00248-X . PMID   15035981. S2CID   12656737.
• Gocke CB, Yu H, Kang J (February 2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". The Journal of Biological Chemistry. 280 (6): 5004–12. doi: 10.1074/jbc.M411718200 . PMID   15561718.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lee HS, Lee DC, Park MH, Yang SJ, Lee JJ, Kim DM, Jang Y, Lee JH, Choi JY, Kang YK, Kim DI, Park KC, Kim SY, Yoo HS, Choi EJ, Yeom YI (July 2006). "STMN2 is a novel target of beta-catenin/TCF-mediated transcription in human hepatoma cells". Biochemical and Biophysical Research Communications. 345 (3): 1059–67. doi:10.1016/j.bbrc.2006.05.017. PMID   16712787.
• Manna T, Grenningloh G, Miller HP, Wilson L (March 2007). "Stathmin family protein SCG10 differentially regulates the plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth". Biochemistry. 46 (11): 3543–52. doi:10.1021/bi061819d. PMID   17311410.