RGS6

RGS6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ES0
Identifiers
Aliases	RGS6 , GAP, regulator of G-protein signaling 6, regulator of G protein signaling 6, HA117, S914
External IDs	OMIM: 603894; MGI: 1354730; HomoloGene: 68385; GeneCards: RGS6; OMA:RGS6 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q24.2 Start 71,932,439 bp [1] End 72,566,529 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12 D1|12 38.14 cM Start 82,635,066 bp [2] End 83,208,830 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve middle temporal gyrus Achilles tendon prefrontal cortex testicle right frontal lobe primary visual cortex Brodmann area 23 apex of heart buccal mucosa cell Top expressed in facial motor nucleus superior frontal gyrus neural layer of retina primary visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex aortic valve atrium embryo right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity GTPase activity Cellular component cytosol plasma membrane membrane nucleus extrinsic component of membrane cytoplasm intracellular anatomical structure Biological process G protein-coupled receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction intracellular signal transduction regulation of G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9628 50779 Ensembl ENSG00000182732 ENSMUSG00000021219 UniProt P49758 Q9Z2H2 RefSeq (mRNA) NM_001204416 NM_001204417 NM_001204418 NM_001204419 NM_001204420 NM_001204421 NM_001204422 NM_001204423 NM_001204424 NM_004296 NM_001282061 NM_015812 NM_001310478 RefSeq (protein) NP_001191345 NP_001191346 NP_001191347 NP_001191348 NP_001191349 NP_001191350 NP_001191351 NP_001191352 NP_001191353 NP_004287 NP_001357199 NP_001357200 NP_001357201 NP_001357202 NP_001357203 NP_001357204 NP_001357205 NP_001357206 NP_001357207 NP_001357208 NP_001357209 NP_001357210 NP_001357211 NP_001357212 NP_001357213 NP_001357215 NP_001357216 NP_001357217 NP_001357218 NP_001357219 NP_001357220 NP_001357221 NP_001357222 NP_001357223 NP_001268990 NP_001297407 NP_056627 Location (UCSC) Chr 14: 71.93 – 72.57 Mb Chr 12: 82.64 – 83.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene. ^{[5] [6] [7]}

Members of the Regulator of G protein signaling (RGS) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the guanine nucleotide-binding G alpha subunit.[supplied by OMIM] ^[7]

Interactions

RGS6 has been shown to interact with STMN2 ^[8] and DMAP1. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000182732 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021219 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). "The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3". Journal of Human Genetics. 44 (2): 138–40. doi: 10.1007/s100380050129 . PMID   10083744.
6. Liu Z, Fisher RA (April 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity". The Journal of Biological Chemistry. 279 (14): 14120–8. doi: 10.1074/jbc.M309547200 . PMID   14734556.
7. "Entrez Gene: RGS6 regulator of G-protein signalling 6".
8. Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". The Journal of Biological Chemistry. 277 (40): 37832–9. doi: 10.1074/jbc.M205908200 . PMID   12140291.

Further reading

• Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH (June 1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–60. Bibcode:1995Natur.375..754S. doi:10.1038/375754a0. PMID   7596406. S2CID   4308372.
• Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP (May 1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6489–94. Bibcode:1999PNAS...96.6489S. doi: 10.1073/pnas.96.11.6489 . PMC   26909 . PMID   10339615.
• Posner BA, Gilman AG, Harris BA (October 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". The Journal of Biological Chemistry. 274 (43): 31087–93. doi: 10.1074/jbc.274.43.31087 . PMID   10521509.
• Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". The Journal of Biological Chemistry. 277 (40): 37832–9. doi: 10.1074/jbc.M205908200 . PMID   12140291.
• Chatterjee TK, Fisher RA (August 2003). "Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins". The Journal of Biological Chemistry. 278 (32): 30272–82. doi: 10.1074/jbc.M212688200 . PMID   12761220.
• Chatterjee TK, Liu Z, Fisher RA (August 2003). "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants". The Journal of Biological Chemistry. 278 (32): 30261–71. doi: 10.1074/jbc.M212687200 . PMID   12761221.