STRN4

STRN4
Identifiers
Aliases	STRN4 , ZIN, zinedin, PPP2R6C, striatin 4
External IDs	OMIM: 614767; MGI: 2142346; HomoloGene: 8378; GeneCards: STRN4; OMA:STRN4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.32 Start 46,719,511 bp [1] End 46,746,994 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A2 Start 16,549,814 bp [2] End 16,574,856 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sural nerve ganglionic eminence stromal cell of endometrium ventricular zone body of uterus granulocyte muscle layer of sigmoid colon apex of heart Top expressed in spermatocyte dentate gyrus of hippocampal formation granule cell spermatid superior frontal gyrus primary visual cortex neural layer of retina ventricular zone internal carotid artery hippocampus proper external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase 2A binding protein binding calmodulin binding armadillo repeat domain binding protein domain specific binding protein-containing complex binding Cellular component cytoplasm dendritic spine protein phosphatase type 2A complex cell projection membrane protein-containing complex dendrite FAR/SIN/STRIPAK complex Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29888 97387 Ensembl ENSG00000090372 ENSMUSG00000030374 UniProt Q9NRL3 P58404 RefSeq (mRNA) NM_001039877 NM_013403 NM_001039878 NM_133789 RefSeq (protein) NP_001034966 NP_037535 NP_001034967 NP_598550 Location (UCSC) Chr 19: 46.72 – 46.75 Mb Chr 7: 16.55 – 16.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Striatin-4 is a protein that in humans is encoded by the STRN4 gene. ^{[5] [6]}

Interactions

STRN4 has been shown to interact with STK24. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000090372 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030374 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A (Aug 2000). "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain". J. Biol. Chem. 275 (26): 19970–7. doi: 10.1074/jbc.M909782199 . PMID   10748158.
6. "Entrez Gene: STRN4 striatin, calmodulin binding protein 4".
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1) 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
8. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi: 10.1074/mcp.M800266-MCP200 . PMC   2621004 . PMID   18782753.

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1) 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Gaillard S, Bartoli M, Castets F, Monneron A (2001). "Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1". FEBS Lett. 508 (1): 49–52. doi:10.1016/S0014-5793(01)03020-4. PMID   11707266. S2CID   7887096.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.