SULT1C3

SULT1C3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H8K, 2REO
Identifiers
Aliases	SULT1C3 , ST1C3, sulfotransferase family 1C member 3
External IDs	OMIM: 617151 MGI: 102928 HomoloGene: 56817 GeneCards: SULT1C3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	108,265,351 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	54,297,702 bp
RNA expression pattern
	Top expressed in
	duodenum; ; rectum; ; gastric mucosa; ; body of stomach; ; kidney; ; prostate; ; kidney; ; appendix; ; vagina; ; fundus;
	Top expressed in
	olfactory epithelium; ; retinal pigment epithelium; ; trachea; ; conjunctival fornix; ; secondary oocyte; ; submandibular gland; ; sexually immature organism; ; hippocampal formation; ; hippocampus proper; ; thorax;
	More reference expression data
	n/a
Gene ontology
Molecular function	alcohol sulfotransferase activity ; aryl sulfotransferase activity ; sulfotransferase activity ; transferase activity ;
Cellular component	cytoplasm ;
Biological process	sulfur compound metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	442038
	20888
	ENSG00000196228
	ENSMUSG00000023943
	Q6IMI6
	Q80VR3
	NM_001008743 ; NM_001320878
	NM_018751
	NP_001008743 ; NP_001307807
	NP_061221
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 19, 2024

Sulfotransferase 1C3, also known as ST1C3, is an enzyme that in humans is encoded by the SULT1C3 gene.^[5]^[6]^[7]

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.^[5]

Clinical significance

ST1C3 sulfates large benzylic alcohols such as 1-hydroxymethyl-pyrene to chemically reactive mutagenic sulpho conjugates.^[8]

Related Research Articles

Sulfotransferase 1A3/1A4 is an enzyme that in humans is encoded by the SULT1A3 gene.

Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.

Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene.

Sulfotransferase 1A2 is an enzyme that in humans is encoded by the SULT1A2 gene.

Sulfotransferase 1C2 is an enzyme that in humans is encoded by the SULT1C2 gene.

Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene.

Sulfotransferase family cytosolic 1B member 1 is an enzyme that in humans is encoded by the SULT1B1 gene.

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.

Sulfotransferase 1C4 is an enzyme that in humans is encoded by the SULT1C4 gene.

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.

Galactose-3-O-sulfotransferase 4 is an enzyme that in humans is encoded by the GAL3ST4 gene.

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.

Heparan sulfate 6-O-sulfotransferase 2 is a protein that in humans is encoded by the HS6ST2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196228 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023943 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: sulfotransferase family".
↑ Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM (2004). "Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes". Pharmacogenomics J. 4 (1): 54–65. doi:10.1038/sj.tpj.6500223. PMID 14676822. S2CID 17481502.
↑ Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH (May 2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi: 10.1371/journal.pbio.0050097 . PMC 1847840 . PMID 17425406.
↑ Meinl W, Donath C, Schneider H, Sommer Y, Glatt H (April 2008). "SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens". Food Chem. Toxicol. 46 (4): 1249–56. doi:10.1016/j.fct.2007.08.040. PMID 17936463.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Sulfotransferase 1C3 (SULT1C3)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196228 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023943 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: sulfotransferase family".

[pmid14676822-6] Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM (2004). "Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes". Pharmacogenomics J. 4 (1): 54–65. doi:10.1038/sj.tpj.6500223. PMID 14676822. S2CID 17481502.

[pmid17425406-7] Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH (May 2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi: 10.1371/journal.pbio.0050097 . PMC 1847840 . PMID 17425406.

[pmid17936463-8] Meinl W, Donath C, Schneider H, Sommer Y, Glatt H (April 2008). "SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens". Food Chem. Toxicol. 46 (4): 1249–56. doi:10.1016/j.fct.2007.08.040. PMID 17936463.

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