SUMF2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | SUMF2 , pFGE, sulfatase modifying factor 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 607940; MGI: 1915152; HomoloGene: 41037; GeneCards: SUMF2; OMA:SUMF2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Sulfatase-modifying factor 2 is an enzyme that in humans is encoded by the SUMF2 gene. [5] [6]
The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [6]
Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene. ELGN2 is an alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins.
Eukaryotic translation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene.
60S ribosomal protein L36 is a protein that in humans is encoded by the RPL36 gene.
60S ribosomal protein L10a is a protein that in humans is encoded by the RPL10A gene.
60S ribosomal protein L24 is a protein that in humans is encoded by the RPL24 gene.
Sulfatase-modifying factor 1 is an enzyme that in humans is encoded by the SUMF1 gene.
Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene.
60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene.
U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.
Carbonic anhydrase-related protein 10 is an enzyme that in humans is encoded by the CA10 gene.
Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene.
Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.
Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.
Large ribosomal subunit protein uL22 is a protein that in humans is encoded by the RPL17 gene.
Polypeptide N-acetylgalactosaminyltransferase 11 is an enzyme that in humans is encoded by the GALNT11 gene.
Zinc finger protein 19 is a protein that in humans is encoded by the ZNF19 gene.
Serine/threonine-protein kinase 40 is an enzyme that in humans is encoded by the STK40 gene.
Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.
CD99 antigen-like protein 2 is a protein that in humans is encoded by the CD99L2 gene.
Formylglycine-generating enzyme (FGE), located at 3p26.1 in humans, is the name for an enzyme present in the endoplasmic reticulum that catalyzes the conversion of cysteine to formylglycine (fGly). There are two main classes of FGE, aerobic and anaerobic. FGE activates sulfatases, which are essential for the degradation of sulfate esters. The catalytic activity of sulfatases is dependent upon a formylglycine residue in the active site.