SUMF2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | SUMF2 , pFGE, sulfatase modifying factor 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 607940 MGI: 1915152 HomoloGene: 41037 GeneCards: SUMF2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Sulfatase-modifying factor 2 is an enzyme that in humans is encoded by the SUMF2 gene. [5] [6]
The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [6]
Steroid sulfatase (STS), or steryl-sulfatase, formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded by the STS gene.
N-acetylgalactosamine-6-sulfatase is an enzyme that, in humans, is encoded by the GALNS gene.
Alpha-1,2-mannosyltransferase ALG9 is an enzyme that in humans is encoded by the ALG9 gene.
60S ribosomal protein L36 is a protein that in humans is encoded by the RPL36 gene.
60S ribosomal protein L10a is a protein that in humans is encoded by the RPL10A gene.
60S ribosomal protein L24 is a protein that in humans is encoded by the RPL24 gene.
Sulfatase-modifying factor 1 is an enzyme that in humans is encoded by the SUMF1 gene.
Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene.
60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene.
Serine protease 23 is an enzyme that in humans is encoded by the PRSS23 gene.
Carbonic anhydrase-related protein 10 is an enzyme that in humans is encoded by the CA10 gene.
Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene.
Diphthine synthase is an enzyme that in humans is encoded by the DPH5 gene.
NADH dehydrogenase [ubiquinone] 1 subunit C2 is an enzyme that in humans is encoded by the NDUFC2 gene.
Tyrosine-protein kinase STYK1 is an enzyme that in humans is encoded by the STYK1 gene.
60S ribosomal protein L17 is a protein that in humans is encoded by the RPL17 gene.
Chondroitin sulfate synthase 2 is an enzyme that in humans is encoded by the CHPF gene.
Serine/threonine-protein kinase 40 is an enzyme that in humans is encoded by the STK40 gene.
Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.
Formylglycine-generating enzyme (FGE), located at 3p26.1 in humans, is the name for an enzyme present in the endoplasmic reticulum that catalyzes the conversion of cysteine to formylglycine (fGly). There are two main classes of FGE, aerobic and anaerobic. FGE activates sulfatases, which are essential for the degradation of sulfate esters. The catalytic activity of sulfatases is dependent upon a formylglycine residue in the active site.