SURF4

SURF4
Identifiers
Aliases	SURF4 , ERV29, surfeit 4
External IDs	OMIM: 185660 MGI: 98445 HomoloGene: 6052 GeneCards: SURF4
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,376,166 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; stromal cell of endometrium; ; duodenum; ; body of pancreas; ; placenta; ; right lobe of liver; ; gallbladder; ; smooth muscle tissue; ; Left adrenal gland; ; left uterine tube;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	integral component of membrane ; Golgi apparatus ; endoplasmic reticulum-Golgi intermediate compartment membrane ; endoplasmic reticulum ; membrane ; endoplasmic reticulum-Golgi intermediate compartment ; transport vesicle ; endoplasmic reticulum membrane ; Golgi membrane ; plasma membrane ; azurophil granule membrane ; cytosol ;
Biological process	early endosome to Golgi transport ; positive regulation of organelle organization ; protein exit from endoplasmic reticulum ; Golgi organization ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ; neutrophil degranulation ;
	Sources:Amigo / QuickGO
Orthologs
	6836
	20932
	ENSG00000148248 ; ENSG00000280951
	n/a
	O15260
	Q64310
NM_001280788 ; NM_001280789 ; NM_001280790 ; NM_001280791 ; NM_001280792 ;
	NM_001280793 ; NM_033161
	NM_011512
NP_001267717 ; NP_001267718 ; NP_001267719 ; NP_001267720 ; NP_001267721 ;
	NP_001267722 ; NP_149351
	NP_035642
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies.^[4]^[5] Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9.^[4] It recognizes cargo proteins via a three-amino-acid sequence near the N-termini.^[4] The related protein in yeast is called Erv29p.^[5]

This gene is named based on its location in the surfeit gene cluster, composed of six housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. Surf4's yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles.^[6]

Eliminating Surf4 in the liver reduces the amount of lipid in the plasma and prevents atherosclerosis in mice.^[4]

Related Research Articles

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References

1 2 3 ENSG00000280951 GRCh38: Ensembl release 89: ENSG00000148248, ENSG00000280951 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 Sun S, Tang X, Guo Y, Hu J (August 2021). "Endoplasmic reticulum composition and form: Proteins in and out". Current Opinion in Cell Biology. 71: 1–6. doi:10.1016/j.ceb.2021.01.008. PMID 33611096. S2CID 231987943.
1 2 "SURF4 Gene - Surfeit 4" . Retrieved 8 June 2022.
↑ "Entrez Gene: SURF4 surfeit 4".

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000280951 GRCh38: Ensembl release 89: ENSG00000148248, ENSG00000280951 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Sun2021-4] 1 2 3 4 Sun S, Tang X, Guo Y, Hu J (August 2021). "Endoplasmic reticulum composition and form: Proteins in and out". Current Opinion in Cell Biology. 71: 1–6. doi:10.1016/j.ceb.2021.01.008. PMID 33611096. S2CID 231987943.

[GeneCards-5] 1 2 "SURF4 Gene - Surfeit 4" . Retrieved 8 June 2022.

[entrez-6] "Entrez Gene: SURF4 surfeit 4".

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