SURF4

Last updated
SURF4
Identifiers
Aliases SURF4 , ERV29, surfeit 4
External IDs OMIM: 185660; MGI: 98445; HomoloGene: 6052; GeneCards: SURF4; OMA:SURF4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011512

RefSeq (protein)

NP_035642

Location (UCSC) Chr 9: 133.36 – 133.38 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies. [4] [5] Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9. [4] It recognizes cargo proteins via a three-amino-acid sequence near the N-termini. [4] The related protein in yeast is called Erv29p. [5]

This gene is named based on its location in the surfeit gene cluster, composed of six housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. Surf4's yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles. [6]

Eliminating Surf4 in the liver reduces the amount of lipid in the plasma and prevents atherosclerosis in mice. [4]

References

  1. 1 2 3 ENSG00000280951 GRCh38: Ensembl release 89: ENSG00000148248, ENSG00000280951 Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. 1 2 3 4 Sun S, Tang X, Guo Y, Hu J (August 2021). "Endoplasmic reticulum composition and form: Proteins in and out". Current Opinion in Cell Biology. 71: 1–6. doi:10.1016/j.ceb.2021.01.008. PMID   33611096. S2CID   231987943.
  5. 1 2 "SURF4 Gene - Surfeit 4" . Retrieved 8 June 2022.
  6. "Entrez Gene: SURF4 surfeit 4".