SURF6

SURF6
Identifiers
Aliases	SURF6 , RRP14, surfeit 6
External IDs	OMIM: 185642 MGI: 98447 HomoloGene: 133981 GeneCards: SURF6
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.2 Start 133,328,776 bp [1] End 133,336,188 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 A3|2 19.08 cM Start 26,778,640 bp [2] End 26,792,891 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastrocnemius muscle substantia nigra temporal lobe small intestine amygdala hypothalamus skin of abdomen prefrontal cortex left adrenal gland Top expressed in external carotid artery internal carotid artery primitive streak ascending aorta supraoptic nucleus aortic valve lacrimal gland hair follicle prostate cumulus cell More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding RNA binding Cellular component nucleolus nucleus nucleoplasm granular component cytosolic large ribosomal subunit Biological process ribosome biogenesis ribosomal large subunit biogenesis ribosomal small subunit biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6838 20935 Ensembl ENSG00000148296 ENSG00000281309 ENSMUSG00000036160 UniProt O75683 P70279 RefSeq (mRNA) NM_001278942 NM_006753 NM_009298 RefSeq (protein) NP_001265871 NP_006744 NP_033324 Location (UCSC) Chr 9: 133.33 – 133.34 Mb Chr 2: 26.78 – 26.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Surfeit locus protein 6 is a protein that in humans is encoded by the SURF6 gene. ^{[5] [6]}

This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse. ^[6]

References

1. ENSG00000281309 GRCh38: Ensembl release 89: ENSG00000148296, ENSG00000281309 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036160 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Duhig T, Ruhrberg C, Mor O, Fried M (May 1999). "The human Surfeit locus". Genomics. 52 (1): 72–8. doi:10.1006/geno.1998.5372. PMID   9740673.
6. "Entrez Gene: SURF6 surfeit 6".

Further reading

• Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum. Mol. Genet. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID   8499913.
• Magoulas C, Fried M (1996). "The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein". DNA Cell Biol. 15 (4): 305–16. doi:10.1089/dna.1996.15.305. PMID   8639267.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Magoulas C, Zatsepina OV, Jordan PW, et al. (1998). "The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro". Eur. J. Cell Biol. 75 (2): 174–83. doi:10.1016/s0171-9335(98)80059-9. PMID   9548374.
• Magoulas C, Fried M (2000). "Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus". Gene. 243 (1–2): 115–23. doi:10.1016/S0378-1119(99)00551-X. PMID   10675619.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Angiolillo A, Russo G, Porcellini A, et al. (2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts". Gene. 284 (1–2): 169–78. doi:10.1016/S0378-1119(02)00379-7. PMID   11891058.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.