SYCP1

SYCP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YTO
Identifiers
Aliases	SYCP1 , CT8, HOM-TES-14, SCP-1, SCP1, synaptonemal complex protein 1
External IDs	OMIM: 602162; MGI: 105931; HomoloGene: 2389; GeneCards: SYCP1; OMA:SYCP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.2 Start 114,854,863 bp [1] End 114,995,370 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.2 Start 102,725,815 bp [2] End 102,843,416 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right testis left testis buccal mucosa cell testicle gonad granulocyte tibialis anterior muscle ventricular zone mononuclear cell Top expressed in spermatocyte spermatid seminiferous tubule morula zygote secondary oocyte fallopian tube embryo primary oocyte embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding double-stranded DNA binding Cellular component condensed nuclear chromosome central element male germ cell nucleus chromosome transverse filament nucleus synaptonemal complex chromosome, centromeric region Biological process lateral element assembly spermatogenesis meiosis sperm DNA condensation regulation of protein localization meiotic DNA repair synthesis chiasma assembly cell division cell cycle synaptonemal complex assembly homologous chromosome pairing at meiosis reciprocal meiotic recombination protein homotetramerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6847 20957 Ensembl ENSG00000198765 ENSMUSG00000027855 UniProt Q15431 Q62209 RefSeq (mRNA) NM_001282541 NM_001282542 NM_003176 NM_011516 RefSeq (protein) NP_001269470 NP_001269471 NP_003167 NP_001269470.1 NP_003167.2 NP_035646 Location (UCSC) Chr 1: 114.85 – 115 Mb Chr 3: 102.73 – 102.84 Mb PubMed search [3] [4]
Wikidata
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Synaptonemal complex protein 1 is a protein involved in the synaptonemal complex during meiosis, that in humans is encoded by the SYCP1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000198765 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027855 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tureci O, Sahin U, Zwick C, Koslowski M, Seitz G, Pfreundschuh M (Jun 1998). "Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens". Proc Natl Acad Sci U S A. 95 (9): 5211–6. Bibcode:1998PNAS...95.5211T. doi: 10.1073/pnas.95.9.5211 . PMC   20240 . PMID   9560255.
6. "Entrez Gene: SYCP1 synaptonemal complex protein 1".

Further reading

• Neumann F, Wagner C, Preuss KD, et al. (2005). "Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells". Blood. 106 (9): 3105–13. doi: 10.1182/blood-2005-04-1487 . PMID   16030183.
• Costa Y, Speed R, Ollinger R, et al. (2005). "Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis". J. Cell Sci. 118 (Pt 12): 2755–62. doi: 10.1242/jcs.02402 . PMID   15944401.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi: 10.1073/pnas.021386498 . PMC   14639 . PMID   11149944.
• Kondoh N, Nishina Y, Tsuchida J, et al. (1997). "Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis". Cytogenet. Cell Genet. 78 (2): 103–4. doi:10.1159/000134637. PMID   9371398.
• Meuwissen RL, Meerts I, Hoovers JM, et al. (1997). "Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene" (PDF). Genomics. 39 (3): 377–84. doi:10.1006/geno.1996.4373. PMID   9119375. S2CID   260928260.
• Meuwissen RL, Offenberg HH, Dietrich AJ, et al. (1993). "A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes". EMBO J. 11 (13): 5091–100. doi:10.1002/j.1460-2075.1992.tb05616.x. PMC   556987 . PMID   1464329.

External links

• Overview of all the structural information available in the PDB for UniProt : Q62209 (Synaptonemal complex protein 1) at the PDBe-KB .