Sivelestat

Last updated
Sivelestat
Sivelestat.svg
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration 		IV
ATC code
  • None
Legal status
Legal status
  • US:Not approved
  • In general: ℞ (Prescription only)
Identifiers
  • N-{2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C20H22N2O7S
Molar mass 434.46 g·mol−1
3D model (JSmol)
  • CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
  • InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24) Yes check.svgY
  • Key:BTGNGJJLZOIYID-UHFFFAOYSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase. [1]

It is used in the treatment of acute respiratory failure [2] and preliminary studies show it may also improve neuropathic pain. [3]

Synthesis

Sivelestat is synthesised as follows: [4]

Sivelestat scheme.png

References

  1. ↑ Kawabata K, Suzuki M, Sugitani M, Imaki K, Toda M, Miyamoto T (June 1991). "ONO-5046, a novel inhibitor of human neutrophil elastase". Biochemical and Biophysical Research Communications. 177 (2): 814–820. Bibcode:1991BBRC..177..814K. doi:10.1016/0006-291X(91)91862-7. PMID   2049103.
  2. ↑ Imokawa S, Mori K, Harada M, Sagisaka S, Sano T, Uchiyama H, et al. (June 2008). "[Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate]". Nihon Kokyuki Gakkai Zasshi = The Journal of the Japanese Respiratory Society (in Japanese). 46 (6): 461–465. PMID   18592991.
  3. ↑ Weyer AD, Stucky CL (May 2015). "Repurposing a leukocyte elastase inhibitor for neuropathic pain". Nature Medicine. 21 (5): 429–430. doi:10.1038/nm.3861. PMID   25951529. S2CID   10240018.
  4. ↑ US 5017610,Imaki K, Arai Y, Okegawa T,"Derivatives of p-substituted phenyl ester of pivalic acid",issued 21 May 1991, assigned to Ono Pharmaceutical Co Ltd
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.