Sodium calcium edetate

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Sodium calcium edetate
Sodium calcium edetate.svg
Clinical data
Trade names Calcium disodium versenate, others
Other namescalcium disodium EDTA, edetate calcium disodium, sodium calcium edetate
AHFS/Drugs.com Monograph
Routes of
administration
IV, IM
Drug class chelating agent
ATC code
Legal status
Legal status
Identifiers
  • Calcium disodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
E number E385 (antioxidants, ...) OOjs UI icon edit-ltr-progressive.svg
CompTox Dashboard (EPA)
ECHA InfoCard 100.000.482 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C10H12CaN2Na2O8
Molar mass 374.270 g·mol−1
3D model (JSmol)
  • C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Ca+2]
  • InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
  • Key:SHWNNYZBHZIQQV-UHFFFAOYSA-J

Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning, [2] including both short-term and long-term lead poisoning. [3] Sodium calcium edetate came into medical use in the United States in 1953. [3]

Contents

Chelation agent

Sodium calcium edetate is in the chelating agent family of medication. [3] It is a salt of edetate with two sodium and one calcium atoms. [4] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine. [3]

Edetate disodium (Endrate) is a different formulation which does not have the same effects. [3]

Medical use

Sodium calcium edetate's primary use is to treat lead poisoning, [2] for which it is an alternative to succimer. [3] It is given by slow injection into a vein or into a muscle. [2]

For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol. [3] It may also be used to treat plutonium poisoning. [5] It does not appear to be useful for poisoning by tetra-ethyl lead. [3]

Side effects

Common side effects include pain at the site of injection. [3] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure. [2] Benefits when needed in pregnancy are likely greater than the risks. [3]

History

Sodium calcium edetate came into medical use in the United States in 1953. [3] It is on the World Health Organization's List of Essential Medicines. [6]

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References

  1. "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA . Retrieved 22 October 2023.
  2. 1 2 3 4 Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. pp. 59, 62, 65. hdl: 10665/44053 . ISBN   9789241547659.
  3. 1 2 3 4 5 6 7 8 9 10 11 "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
  4. Kasture AV (2008). Pharmaceutical Chemistry. Vol. I. Pragati Books Pvt. Ltd. p. 16.11. ISBN   9788185790121. Archived from the original on 16 January 2017.
  5. Flanagan R, Jones A, Maynard RL (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN   9780203485071. Archived from the original on 16 January 2017.
  6. Organization WH (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva,CH: World Health Organization. hdl: 10665/325771 . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.