Spondin 1

SPON1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZOT, 2ZOU, 3COO, 3Q13
Identifiers
Aliases	SPON1 , VSGP/F-spondin, f-spondin, Spondin 1
External IDs	OMIM: 604989 MGI: 2385287 HomoloGene: 4453 GeneCards: SPON1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.2 Start 13,962,723 bp [1] End 14,268,133 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F1 Start 113,365,235 bp [2] End 113,642,605 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder pericardium lower lobe of lung cardia mucosa of urinary bladder external globus pallidus right lung visceral pleura parietal pleura jejunal mucosa Top expressed in iris ciliary body external carotid artery cervix internal carotid artery retinal pigment epithelium atrium suprachiasmatic nucleus aortic valve belly cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding extracellular matrix structural constituent LBD domain binding Cellular component extracellular matrix extracellular region endoplasmic reticulum lumen extracellular space collagen-containing extracellular matrix Biological process cell adhesion protein O-linked fucosylation positive regulation of protein processing positive regulation of protein binding negative regulation of amyloid-beta formation positive regulation of amyloid precursor protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10418 233744 Ensembl ENSG00000262655 ENSMUSG00000038156 UniProt Q9HCB6 Q8VCC9 RefSeq (mRNA) NM_006108 NM_145584 RefSeq (protein) NP_006099 NP_663559 Location (UCSC) Chr 11: 13.96 – 14.27 Mb Chr 7: 113.37 – 113.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene. ^[5] It is secreted by cells of the floor plate and may be involved in axon guidance ^[6] The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

References

1. GRCh38: Ensembl release 89: ENSG00000262655 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038156 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID   9872452.
6. "Entrez Gene: SPON1 spondin 1, extracellular matrix protein".

Further reading

• Nakajima D, Okazaki N, Yamakawa H (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Klar A, Baldassare M, Jessell TM (1992). "F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension". Cell. 69 (1): 95–110. doi:10.1016/0092-8674(92)90121-R. PMID   1555244. S2CID   14880785.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Miyamoto K, Morishita Y, Yamazaki M (2001). "Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary". Arch. Biochem. Biophys. 390 (1): 93–100. doi:10.1006/abbi.2001.2367. PMID   11368520.
• Gonzalez de Peredo A, Klein D, Macek B (2002). "C-mannosylation and o-fucosylation of thrombospondin type 1 repeats". Mol. Cell. Proteomics. 1 (1): 11–8. doi: 10.1074/mcp.M100011-MCP200 . PMID   12096136.
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Ho A, Südhof TC (2004). "Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2548–53. Bibcode:2004PNAS..101.2548H. doi: 10.1073/pnas.0308655100 . PMC   356987 . PMID   14983046.
• Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Pyle-Chenault RA, Stolk JA, Molesh DA (2005). "VSGP/F-spondin: a new ovarian cancer marker". Tumour Biol. 26 (5): 245–57. doi:10.1159/000087379. PMID   16103746. S2CID   13409234.
• Otsuki T, Ota T, Nishikawa T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Kitagawa M, Kudo Y, Iizuka S (2006). "Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells" (PDF). Biochem. Biophys. Res. Commun. 349 (3): 1050–6. doi:10.1016/j.bbrc.2006.08.142. PMID   16965763.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9HCB6 (Spondin-1) at the PDBe-KB .