Professor Stephen J. Challacombe | |
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Born | April 1946 |
Nationality | British |
Education | Guy's Hospital Dental School |
Known for | |
Spouse | Tina |
Children | 2 |
Scientific career | |
Fields |
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Institutions |
Stephen James Challacombe FRC(Path), FDSRCS, FMedSci, (born April 1946) is professor of oral medicine at King's College in London, best known for research in oromucosal immunology and for developing the Challacombe scale for measuring the extent of dryness of the mouth. He led the team that laid out research challenges of global health inequalities and oral health, particularly relating to the oral manifestations of HIV.
Challacombe was the Martin Rushton Professor of Oral Medicine at King's College, London and the University of London, a consultant in diagnostic microbiology and immunology to Guys & St Thomas Hospitals, and Dean for external affairs at King's College London Health Schools.
He has been an author, co-author, editor and co-editor of a number of publications and a recipient of several awards and fellowships. Medical societies of which he has been president include the International Association for Dental Research, British Society for Oral and Dental Research, European Association of Oral Medicine and the Hunterian Society, and the world's oldest rugby club, Guy's Hospital RFC.
Stephen Challacombe was born in April 1946. He attended Culford School, where he played sports including rugby. [1]
He initially worked in the field of immunology. [2] In 1978, he was appointed assistant professor and senior research fellow in the Department of Immunology at the Mayo Clinic in the United States, [3] and completed the fellowship in 1979. [4]
From 1984 to 2011, he was consultant in diagnostic microbiology and immunology to Guys & St Thomas Hospitals. [5] During this time, he became professor of oral medicine in the department of Oral Medicine and Pathology at Guy's Hospital in 1986 and the Martin Rushton Professor of oral medicine in 1988. [2] [6]
Challacombe was appointed Director of External Strategy at the Dental Institute in 2005 and a year later became Dean for King's College London KCL External Affairs, holding both posts until 2011. [5] [7]
His experience has also included coordinating conferences and university departments, managing grants, finances and research, and teaching. [3]
He developed the Challacombe scale for measuring the extent of dryness of the mouth in human beings. It was launched in 2011 at Tylney Hall in Hampshire [8] and has become widely used as a medical tool for assessing and monitoring dry mouth. [9] [10] [11]
Challacombe became involved in clinical research in oral HIV and AIDS, and has chaired international workshops on the oral manifestations of HIV infection in the UK, South Africa, Thailand, China, and India. In 1991 and 1993, he contributed to the consensus meeting on the classification of oral lesions in HIV. [1] [3]
He was chairman of the International Steering Committee on Oral Health and Disease in HIV infection between 2000 and 2017. [3]
In 2011, he led the team that laid out research challenges of global health inequalities and oral health, particularly relating to Noma, tuberculosis, sexually transmitted disease and HIV, four of the most serious global oral health infections. [12] [13] [14] With regards to clinical signs in the mouth in AIDS, he identified a significant role for dentists. [13]
Later, using Sierra Leone as a case study to develop oral health programmes in low-income countries, he worked with the King's Sierra Leone Partnership's dentistry section, [15] as a member of The Kings Centre for Global Health. [1]
In 2020, he co-authored a review which proposed using povidone-iodine to reduce cross-infectivity of COVID-19, [16] and highlighted the role of saliva in the transmission of the disease. [17]
As a historian of medicine, his lectures have included a series on the London medical students at Belsen. [18]
Challacombe is a recipient of a number of awards including:
He has been president of:
He has also been president of the world's oldest rugby club, Guy's Hospital RFC. [1] [20]
He was chairman of:
He is a fellow of the:
He is married to Tina and they have two children. [1]
In 2013, he joined the Board of Governors of Culford School. [1] He also continues to support students of the world's oldest rugby club, Guy's Hospital RFC. [22]
He has been an author, co-author, editor and co-editor of a number of publications including nine books, over 240 peer-reviewed research papers and 160 other works on various aspects of oral and maxillofacial medicine. [3] These have included publications on induction of secretory immune responses, oral tolerance and on immunological aspects of the oral cavity. [2] His interest on mucosal immunity in HIV and how HIV can present with signs in the mouth, has resulted in over 25 research articles. [3]
Dentistry, also known as dental medicine and oral medicine, is the branch of medicine focused on the teeth, gums, and mouth. It consists of the study, diagnosis, prevention, management, and treatment of diseases, disorders, and conditions of the mouth, most commonly focused on dentition as well as the oral mucosa. Dentistry may also encompass other aspects of the craniofacial complex including the temporomandibular joint. The practitioner is called a dentist.
Safe sex is sexual activity using methods or contraceptive devices to reduce the risk of transmitting or acquiring sexually transmitted infections (STIs), especially HIV. "Safe sex" is also sometimes referred to as safer sex or protected sex to indicate that some safe sex practices do not eliminate STI risks. It is also sometimes used colloquially to describe methods aimed at preventing pregnancy that may or may not also lower STI risks.
Necrotizing gingivitis (NG) is a common, non-contagious infection of the gums with sudden onset. The main features are painful, bleeding gums, and ulceration of inter-dental papillae. This disease, along with necrotizing periodontitis (NP) and necrotizing stomatitis, is classified as a necrotizing periodontal disease, one of the three general types of gum disease caused by inflammation of the gums (periodontitis).
A dentist, also known as a dental surgeon, is a health care professional who specializes in dentistry, the branch of medicine focused on the teeth, gums, and mouth. The dentist's supporting team aids in providing oral health services. The dental team includes dental assistants, dental hygienists, dental technicians, and sometimes dental therapists.
Oral candidiasis, also known as oral thrush among other names, is candidiasis that occurs in the mouth. That is, oral candidiasis is a mycosis of Candida species on the mucous membranes of the mouth.
Xerostomia, also known as dry mouth, is dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause.
An oral medicine or stomatology doctor/dentist has received additional specialized training and experience in the diagnosis and management of oral mucosal abnormalities including oral cancer, salivary gland disorders, temporomandibular disorders and facial pain, taste and smell disorders; and recognition of the oral manifestations of systemic and infectious diseases. It lies at the interface between medicine and dentistry. An oral medicine doctor is trained to diagnose and manage patients with disorders of the orofacial region.
Weston Andrew Valleau Price was a Canadian dentist known primarily for his theories on the relationship between nutrition, dental health, and physical health. He founded the research institute National Dental Association, which became the research section of the American Dental Association, and was the NDA's chairman from 1914 to 1928.
Focal infection theory is the historical concept that many chronic diseases, including systemic and common ones, are caused by focal infections. In present medical consensus, a focal infection is a localized infection, often asymptomatic, that causes disease elsewhere in the host, but focal infections are fairly infrequent and limited to fairly uncommon diseases. Focal infection theory, rather, so explained virtually all diseases, including arthritis, atherosclerosis, cancer, and mental illnesses.
Oral and maxillofacial pathology refers to the diseases of the mouth, jaws and related structures such as salivary glands, temporomandibular joints, facial muscles and perioral skin. The mouth is an important organ with many different functions. It is also prone to a variety of medical and dental disorders.
In the United States and Canada, there are twelve recognized dental specialties in which some dentists choose to train and practice, in addition to or instead of general dentistry. In the United Kingdom and Australia, there are thirteen.
Michael Stuart Gottlieb is an American physician and immunologist known for his 1981 identification of acquired immune deficiency syndrome (AIDS) as a new disease, and for his HIV/AIDS research, HIV/AIDS activism, and philanthropic efforts associated with HIV/AIDS treatment.
Human immunodeficiency virus salivary gland disease, is swelling of the salivary glands and/or xerostomia in individuals infected with human immunodeficiency virus.
John C. Greene was an American dentist and public health administrator. He was a rear admiral in the U.S. Public Health Service Commissioned Corps, and served as the Deputy Surgeon General of the United States under President Carter from 1978 to 1981. He was the Acting Surgeon General from January to May 1981 under Ronald Reagan. He was the highest ranking non-physician public health officer in the history of the U.S. government.
The Challacombe scale is a widely used diagnostic medical tool designed to produce a clinical oral dryness score (CODS) which quantifies the extent of dryness of the mouth, with the aim of making a decision of whether to treat or not, and to monitor its progression or regression.
Stephen Porter is Director of UCL Eastman Dental Institute where he has been Professor of Oral Medicine since 1997. He is a consultant in Oral Medicine at University College Hospital, London and a member of the Faculty of Dental Surgery of the Royal College of Surgeons. Porter has published more than 450 scholarly works, including the scientific journals The BMJ, The British Dental Journal and The Journal of the American Dental Association.
John S. Greenspan was an academic dentist/scientist and university administrator. His degrees and diplomas include BSc, BDS, Ph.D., FRCPath, FDSRCS (Eng). He was the Director-Emeritus of the AIDS Research Institute at the University of California, San Francisco (UCSF). He was also the founding Director of the UCSF AIDS Specimen Bank (1982-2017) and of the UCSF Oral AIDS Center (1986–2005).
Niki M. Moutsopoulos is a Greek periodontist and immunologist. She is a senior investigator in the oral immunity and infection section at the National Institute of Dental and Craniofacial Research. Moutsopoulos specializes in oral immunology and periodontitis. Her research program focuses on host-microbial interactions that can drive chronic inflammatory responses and tissue destruction in the oral cavity.
Jennifer Y. Webster-Cyriaque is an American dentist and immunologist specializing in the oral microbiome, salivary gland disease in patients with HIV, and cancer-causing viruses. She became the deputy director of the National Institute of Dental and Craniofacial Research in November 2020. Webster-Cyriaque was a faculty member at UNC Adams School of Dentistry and the UNC School of Medicine for 21 years.