The nucleolus is the largest structure in the nucleus of eukaryotic cells. It is best known as the site of ribosome biogenesis, which is the synthesis of ribosomes. The nucleolus also participates in the formation of signal recognition particles and plays a role in the cell's response to stress. Nucleoli are made of proteins, DNA and RNA, and form around specific chromosomal regions called nucleolar organizing regions. Malfunction of nucleoli can be the cause of several human conditions called "nucleolopathies" and the nucleolus is being investigated as a target for cancer chemotherapy.
Ribosomes ( ), also called Palade granules, are macromolecular machines, found within all cells, that perform biological protein synthesis. Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins. The ribosomes and associated molecules are also known as the translational apparatus.
Rosalind Elsie Franklin was a British chemist and X-ray crystallographer whose work was central to the understanding of the molecular structures of DNA, RNA, viruses, coal, and graphite. Although her works on coal and viruses were appreciated in her lifetime, her contributions to the discovery of the structure of DNA were largely unrecognized during her life, for which she has been variously referred to as the "wronged heroine", the "dark lady of DNA", the "forgotten heroine", a "feminist icon", and the "Sylvia Plath of molecular biology".
Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed from ribosomal DNA (rDNA) and then bound to ribosomal proteins to form small and large ribosome subunits. rRNA is the physical and mechanical factor of the ribosome that forces transfer RNA (tRNA) and messenger RNA (mRNA) to process and translate the latter into proteins. Ribosomal RNA is the predominant form of RNA found in most cells; it makes up about 80% of cellular RNA despite never being translated into proteins itself. Ribosomes are composed of approximately 60% rRNA and 40% ribosomal proteins by mass.
The American Society for Cell Biology (ASCB) is a professional society that was founded in 1960.
The E.B. Wilson Medal is the American Society for Cell Biology's highest honor for science and is presented at the Annual Meeting of the Society for significant and far-reaching contributions to cell biology over the course of a career. It is named after Edmund Beecher Wilson.
The Women In Cell Biology Committee of the American Society for Cell Biology (ASCB) recognizes outstanding achievements by women in cell biology by presenting three Career Recognition Awards at the ASCB Annual Meeting. The Junior Award is given to a woman in an early stage of her career who has made exceptional scientific contributions to cell biology and exhibits the potential for continuing a high level of scientific endeavor while fostering the career development of damaged young scientists. The Mid-Career Award is given to a woman at the mid-career level who has made exceptional scientific contributions to cell biology and/or has effectively translated cell biology across disciplines, and who exemplifies a high level of scientific endeavor and leadership. The Senior Award is given to a woman or man in a later career stage whose outstanding scientific achievements are coupled with a long-standing record of support for women in science and by mentorship of both men and women in scientific careers.
Joseph Grafton Gall is an American cell biologist who is noted for studies revealing the details of chromosome structure and function. Gall's studies were greatly facilitated by his knowledge of many different organisms because he could select the most favorable organism to study when approaching a specific question about nuclear structure. He was awarded the 2006 Albert Lasker Special Achievement Award. He was also a co-recipient of the 2007 Louisa Gross Horwitz Prize from Columbia University. In 1983 he was honored with the highest recognition of the American Society for Cell Biology, the E. B. Wilson Medal. He had been elected to the American Academy of Arts and Sciences in 1968, the National Academy of Sciences in 1972, and the American Philosophical Society in 1989.
Joan Elaine Argetsinger Steitz is Sterling Professor of Molecular Biophysics and Biochemistry at Yale University and Investigator at the Howard Hughes Medical Institute. She is known for her discoveries involving RNA, including ground-breaking insights into how ribosomes interact with messenger RNA by complementary base pairing and that introns are spliced by small nuclear ribonucleic proteins (snRNPs), which occur in eukaryotes. In September 2018, Steitz won the Lasker-Koshland Award for Special Achievement in Medical Science. The Lasker award is often referred to as the 'American Nobel' because 87 of the former recipients have gone on to win Nobel prizes.
Elaine V. Fuchs is an American cell biologist, famous for her work on the biology and molecular mechanisms of mammalian skin and skin diseases, who helped lead the modernization of dermatology. Fuchs pioneered reverse genetics approaches, which assess protein function first and then assess its role in development and disease. In particular, Fuchs researches skin stem cells, and their production of hair and skin. She is an investigator at the Howard Hughes Medical Institute and the Rebecca C. Lancefield Professor of Mammalian Cell Biology and Development at The Rockefeller University.
28S ribosomal RNA is the structural ribosomal RNA (rRNA) for the large subunit (LSU) of eukaryotic cytoplasmic ribosomes, and thus one of the basic components of all eukaryotic cells. It has a size of 25S in plants and 28S in mammals, hence the alias of 25S–28S rRNA.
Andrea Hilary Brand is the Herchel Smith Professor of Molecular Biology and a Fellow of Jesus College, Cambridge. She heads a lab investigating nervous system development at the Gurdon Institute and the Department of Physiology, Development and Neuroscience. She developed the GAL4/UAS system with Norbert Perrimon which has been described as “a fly geneticist's Swiss army knife”.
Ada E. Yonath is an Israeli crystallographer best known for her pioneering work on the structure of ribosomes. She is the current director of the Helen and Milton A. Kimmelman Center for Biomolecular Structure and Assembly of the Weizmann Institute of Science.
Lynne Elizabeth Maquat is an American biochemist and molecular biologist whose research focuses on the cellular mechanisms of human disease. She is an elected member of the American Academy of Arts and Sciences, the National Academy of Sciences and the National Academy of Medicine. She currently holds the J. Lowell Orbison Endowed Chair and is a professor of biochemistry and biophysics, pediatrics and of oncology at the University of Rochester Medical Center. Professor Maquat is also Founding Director of the Center for RNA Biology and Founding Chair of Graduate Women in Science at the University of Rochester.
In molecular biology, hybridization is a phenomenon in which single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules anneal to complementary DNA or RNA. Though a double-stranded DNA sequence is generally stable under physiological conditions, changing these conditions in the laboratory will cause the molecules to separate into single strands. These strands are complementary to each other but may also be complementary to other sequences present in their surroundings. Lowering the surrounding temperature allows the single-stranded molecules to anneal or “hybridize” to each other.
Zena Werb was a professor and the Vice Chair of Anatomy at the University of California, San Francisco. She was also the co-leader of the Cancer, Immunity, and Microenvironment Program at the Hellen Diller Family Comprehensive Cancer Center and a member of the Executive Committee of the Sabre-Sandler Asthma Basic Research Center at UCSF. Her research focused on features of the microenvironment surrounding cells, with particular interest in the extracellular matrix and the role of its protease enzymes in cell signaling.
Obazoa is a proposed sister clade of Amoebozoa. Obazoa is composed of Breviatea, Apusomonadida and Opisthokonta. The term Obazoa is based on the OBA acronym for Opisthokonta, Breviatea, and Apusomonadida.
Dr. Mitchell Sogin is a distinguished senior scientist at the Marine Biological Laboratory in Woods Hole, Massachusetts, whose research investigates the evolution and diversity of single-celled organisms.
Karen Oegema is a molecular cell biologist at the Ludwig Institute for Cancer Research and a professor of cellular and molecular medicine at the University of California, San Diego. She is best known for her research with Caenorhabditis elegans, which her lab uses as a model system in their mission to dissect the molecular mechanics of cytokinesis. She was given the Women in Cell Biology Mid-Career Award for Excellence in Research in 2017, as well as the Women in Cell Biology Junior Award for Excellence in Research in 2006.
Suzanne Eaton was an American scientist and professor of molecular biology at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany.
