Syntaxin binding protein 3

Last updated
STXBP3
Protein STXBP3 PDB 2pjx.png
Identifiers
Aliases STXBP3 , MUNC18-3, MUNC18C, PSP, UNC-18C, Syntaxin binding protein 3
External IDs OMIM: 608339 MGI: 107362 HomoloGene: 5260 GeneCards: STXBP3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007269

NM_011504

RefSeq (protein)

NP_009200

NP_035634

Location (UCSC) Chr 1: 108.75 – 108.81 Mb Chr 3: 108.7 – 108.75 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene. [5] [6]

Contents

Interactions

Syntaxin binding protein 3 has been shown to interact with STX2 [7] and STX4. [7] [8]

Related Research Articles

SNAP25 Protein-coding gene in the species Homo sapiens

Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF Attachment Protein Receptor (t-SNARE) protein encoded by the SNAP25 gene found on chromosome 20p12.2 in humans. SNAP-25 is a component of the trans-SNARE complex, which accounts for membrane fusion specificity and directly executes fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together.

STX1A Protein-coding gene in the species Homo sapiens

Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.

SNAP23 Protein-coding gene in the species Homo sapiens

Synaptosomal-associated protein 23 is a protein that in humans is encoded by the SNAP23 gene. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

STX4 Protein-coding gene in the species Homo sapiens

Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.

SYT1

Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.

VAMP2 Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene.

STXBP1 Protein-coding gene in the species Homo sapiens

Syntaxin-binding protein 1 is a protein that in humans is encoded by the STXBP1 gene. This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4.

STX7 Protein-coding gene in the species Homo sapiens

Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.

NAPA (gene) Protein-coding gene in the species Homo sapiens

N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a SNAP protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells.

KIF5B

Kinesin-1 heavy chain is a protein that in humans is encoded by the KIF5B gene.

VAMP3 Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 3 is a protein that in humans is encoded by the VAMP3 gene.

STX2 Protein-coding gene in the species Homo sapiens

Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene.

STX12

Syntaxin-12 is a protein that in humans is encoded by the STX12 gene.

Vesicle-associated membrane protein 8 Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.

STX8 Protein-coding gene in the species Homo sapiens

Syntaxin-8 is a protein that in humans is encoded by the STX8 gene. Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes.

GOSR1 Protein-coding gene in the species Homo sapiens

Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene.

Syntaxin binding protein 2

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.

SNTG1

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.

STXBP5 Protein-coding gene in the species Homo sapiens

Syntaxin-binding protein 5 is a protein that in humans is encoded by the STXBP5 gene. It is also known as tomosyn, after , "friend" in Japanese, for its role as a binding protein.

STX1B

Syntaxin-1B is a protein that in humans is encoded by the STX1B gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000116266 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027882 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Reed GL, Houng AK, Fitzgerald ML (April 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood. 93 (8): 2617–26. doi:10.1182/blood.V93.8.2617. PMID   10194441.
  6. "Entrez Gene: STXBP3 syntaxin binding protein 3".
  7. 1 2 Schraw TD, Lemons PP, Dean WL, Whiteheart SW (August 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC   1223584 . PMID   12773094.
  8. Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi: 10.1074/jbc.M304261200 . PMID   12832401.

Further reading