| TAGAP | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | TAGAP , ARHGAP47, IDDM21, TAGAP1, FKSG15, T-cell activation RhoGTPase activating protein, T cell activation RhoGTPase activating protein | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609667 MGI: 3615484 HomoloGene: 44943 GeneCards: TAGAP | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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T-cell activation RhoGTPase activating protein is a protein that in humans is encoded by the TAGAP gene. [5]
This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms.
Coeliac disease is a long-term autoimmune disorder, primarily affecting the small intestine, where individuals develop intolerance to gluten, present in foods such as wheat, rye and barley. Classic symptoms include gastrointestinal problems such as chronic diarrhoea, abdominal distention, malabsorption, loss of appetite, and among children failure to grow normally. This often begins between six months and two years of age. Non-classic symptoms are more common, especially in people older than two years. There may be mild or absent gastrointestinal symptoms, a wide number of symptoms involving any part of the body, or no obvious symptoms. Coeliac disease was first described in childhood; however, it may develop at any age. It is associated with other autoimmune diseases, such as Type 1 diabetes mellitus and Hashimoto's thyroiditis, among others.
Dermot P. Kelleher FMedSci is the Dean of the Faculty of Medicine and Vice-President, Health at the University of British Columbia in Vancouver, Canada.
Gluten-sensitive enteropathy–associated conditions are comorbidities or complications of gluten-related gastrointestinal distress. GSE has key symptoms typically restricted to the bowel and associated tissues; however, there are a wide variety of associated conditions. These include bowel disorders, eosinophilic gastroenteritis and increase with coeliac disease (CD) severity. With some early onset and a large percentage of late onset disease, other disorders appear prior to the celiac diagnosis or allergic-like responses markedly increased in GSE. Many of these disorders persist on a strict gluten-free diet, and are thus independent of coeliac disease after triggering. For example, autoimmune thyroiditis is a common finding with GSE.
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine phosphatases. This protein is also called "PEST-domain Enriched Phosphatase" ("PEP") or "Lymphoid phosphatase" ("LYP"). The name LYP is used strictly for the human protein encoded by PTPN22, but the name PEP is used only for its mouse homolog. However, both proteins have similar biological functions and show 70% identity in amino acid sequence. PTPN22 functions as a negative regulator of T cell receptor (TCR) signaling, which maintains homeostasis of T cell compartment.
Protein-arginine deiminase type-4, is a human protein which in humans is encoded by the PADI4 gene. The protein as an enzyme, specifically protein-arginine deiminase, a type of hydrolase.
MYO9B is a gene that encodes the Myosin-IXb protein.
Rnd1 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND1.
Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b, is a human gene.
Enteropathy-associated T-cell lymphoma (EATL), previously termed enteropathy-associated T-cell lymphoma, type I and at one time termed enteropathy-type T-cell lymphoma (ETTL), is a complication of coeliac disease in which a malignant T-cell lymphoma develops in areas of the small intestine affected by the disease's intense inflammation. While a relatively rare disease, it is the most common type of primary gastrointestinal T-cell lymphoma.
An autoimmune disease is a condition arising from an abnormal immune response to a functioning body part. Examples include coeliac disease, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, Alopecia Areata, and systemic lupus erythematosus At least 80 types of autoimmune diseases have been identified, with some evidence suggesting that there may be more than 100 types. Nearly any body part can be involved. Common symptoms can be transient and generally include low grade fever and feeling tired.
The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator.
HMG box transcription factor BBX also known as bobby sox homolog or HMG box-containing protein 2 is a protein that in humans is encoded by the BBX gene.
Mitochondrial 2-oxodicarboxylate carrier also known as solute carrier family 25 member 21 (SLC25A21) is a protein that in humans is encoded by the SLC25A21 gene.
AUTS2, activator of transcription and developmental regulator is a protein that in humans is encoded by the AUTS2 gene.
ABI family member 3 binding protein is a protein that in humans is encoded by the ABI3BP gene.
Tetraspanin 18 is a protein that in humans is encoded by the TSPAN18 gene.
Vestigial like family member 4 is a protein that in humans is encoded by the VGLL4 gene.
ATP/GTP binding protein like 4 is a protein that in humans is encoded by the AGBL4 gene.
Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene.
ST6 beta-galactoside alpha-2,6-sialyltransferase 2 is a protein that in humans is encoded by the ST6GAL2 gene.
 | This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
