TAFA5

TAFA5
Identifiers
Aliases	TAFA5 , QLLK5208, TAFA-5, UNQ5208, family with sequence similarity 19 (chemokine (C-C motif)-like), member A5, family with sequence similarity 19 member A5, C-C motif chemokine like, TAFA chemokine like family member 5, FAM19A5
External IDs	OMIM: 617499; MGI: 2146182; HomoloGene: 22888; GeneCards: TAFA5; OMA:TAFA5 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.32 Start 48,489,553 bp [1] End 48,850,912 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E3 Start 87,428,500 bp [2] End 87,643,565 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis tibial nerve hypothalamus amygdala hippocampus proper entorhinal cortex Brodmann area 9 postcentral gyrus right frontal lobe superior frontal gyrus Top expressed in superior colliculus central gray substance of midbrain dorsal tegmental nucleus lateral septal nucleus nucleus of stria terminalis anterior amygdaloid area ventral tegmental area inferior colliculi dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity Cellular component membrane integral component of membrane extracellular region extracellular space Biological process regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25817 106014 Ensembl ENSG00000219438 ENSMUSG00000054863 UniProt Q7Z5A7 Q91WE9 RefSeq (mRNA) NM_015381 NM_001082967 NM_001252310 NM_134096 RefSeq (protein) NP_001076436 NP_056196 NP_001239239 NP_598857 Location (UCSC) Chr 22: 48.49 – 48.85 Mb Chr 15: 87.43 – 87.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chemokine-like protein TAFA-5 is a protein that in humans is encoded by the TAFA5 gene. ^{[5] [6]}

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to CCL3, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000219438 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054863 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID   15028294.
6. "TAFA5 TAFA chemokine like family member 5 [ Homo sapiens (human) ]". National Center for Biotechnology Information . Retrieved 11 August 2019.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.