TAFA5

TAFA5
Identifiers
Aliases	TAFA5 , QLLK5208, TAFA-5, UNQ5208, family with sequence similarity 19 (chemokine (C-C motif)-like), member A5, family with sequence similarity 19 member A5, C-C motif chemokine like, TAFA chemokine like family member 5, FAM19A5
External IDs	OMIM: 617499; MGI: 2146182; HomoloGene: 22888; GeneCards: TAFA5; OMA:TAFA5 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	48,850,912 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	87,643,565 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; tibial nerve; ; hypothalamus; ; amygdala; ; hippocampus proper; ; entorhinal cortex; ; Brodmann area 9; ; postcentral gyrus; ; right frontal lobe; ; superior frontal gyrus;
	Top expressed in
	superior colliculus; ; central gray substance of midbrain; ; dorsal tegmental nucleus; ; lateral septal nucleus; ; nucleus of stria terminalis; ; anterior amygdaloid area; ; ventral tegmental area; ; inferior colliculi; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity ;
Cellular component	membrane ; integral component of membrane ; extracellular region ; extracellular space ;
Biological process	regulation of signaling receptor activity ; signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	25817
	106014
	ENSG00000219438
	ENSMUSG00000054863
	Q7Z5A7
	Q91WE9
	NM_015381 ; NM_001082967
	NM_001252310 ; NM_134096
	NP_001076436 ; NP_056196
	NP_001239239 ; NP_598857
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 16, 2024

Chemokine-like protein TAFA-5 is a protein that in humans is encoded by the TAFA5 gene.^[5]^[6]

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to CCL3, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells.^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000219438 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054863 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.
1 2 "TAFA5 TAFA chemokine like family member 5 [ Homo sapiens (human) ]". National Center for Biotechnology Information . Retrieved 11 August 2019.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000219438 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054863 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15028294-5] Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.

[entrez-6] 1 2 "TAFA5 TAFA chemokine like family member 5 [ Homo sapiens (human) ]". National Center for Biotechnology Information . Retrieved 11 August 2019.

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TAFA5

Related Research Articles

References

Further reading