TBCB

TBCB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V6E, 1WHG
Identifiers
Aliases	TBCB , CG22, CKAP1, CKAPI, tubulin folding cofactor B
External IDs	OMIM: 601303 MGI: 1913661 HomoloGene: 981 GeneCards: TBCB
Gene location (Human)
Chr.	Chromosome 19 (human)
End	36,125,947 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	29,931,697 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; pons; ; prefrontal cortex; ; middle frontal gyrus; ; inferior olivary nucleus; ; hypothalamus; ; substantia nigra; ; superior vestibular nucleus; ; amygdala; ; Brodmann area 9;
	Top expressed in
	facial motor nucleus; ; barrel cortex; ; anterior horn of spinal cord; ; superior cervical ganglion; ; motor neuron; ; medial ganglionic eminence; ; medullary collecting duct; ; maxillary prominence; ; endocardial cushion; ; optic nerve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; microtubule cytoskeleton ; microtubule ; cytoskeleton ; cytosol ;
Biological process	multicellular organism development ; cell differentiation ; nervous system development ;
	Sources:Amigo / QuickGO
Orthologs
	1155
	66411
	ENSG00000105254
	ENSMUSG00000006095
	Q99426
	Q9D1E6
	NM_001300971 ; NM_001281
	NM_025548 ; NM_001360648 ; NM_001360649
	NP_001272 ; NP_001287900
	NP_079824 ; NP_001347577 ; NP_001347578
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2022

Tubulin-folding cofactor B is a protein that in humans is encoded by the TBCB gene.^[5]^[6]

Related Research Articles

Keratin 15 is a protein that in humans is encoded by the KRT15 gene.

Chloride intracellular channel 4, also known as CLIC4, is a eukaryotic gene.

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.

Tubulin-specific chaperone E is a protein that in humans is encoded by the TBCE gene.

DnaJ homolog subfamily B member 11 is a protein that in humans is encoded by the DNAJB11 gene.

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene.

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

Ras-related protein Rab-13 is a protein that in humans is encoded by the RAB13 gene.

Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene.

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.

Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the DNAJC7 gene.

Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.

Tubulin-specific chaperone A is a protein that in humans is encoded by the TBCA gene.

Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.

Pirin is a protein that in humans is encoded by the PIR gene.

Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105254 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006095 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Watanabe TK, Shimizu F, Nagata M, Kawai A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Jan 1997). "Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain". Cytogenet Cell Genet. 72 (2–3): 208–11. doi:10.1159/000134191. PMID 8978778.
↑ "Entrez Gene: TBCB tubulin folding cofactor B".

Wolz W, Wendelmuth U, Rouquier S, et al. (1997). "A complex satellite DNA polymorphism flanking the human ryanodine receptor gene (RYR1)". Cytogenet. Cell Genet. 72 (2–3): 215–6. doi:10.1159/000134193. PMID 8978780.
Tian G, Lewis SA, Feierbach B, et al. (1997). "Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors". J. Cell Biol. 138 (4): 821–32. doi:10.1083/jcb.138.4.821. PMC 2138046 . PMID 9265649.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Vadlamudi RK, Barnes CJ, Rayala S, et al. (2005). "p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B". Mol. Cell. Biol. 25 (9): 3726–36. doi:10.1128/MCB.25.9.3726-3736.2005. PMC 1084301 . PMID 15831477.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Wang W, Ding J, Allen E, et al. (2006). "Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway". Curr. Biol. 15 (22): 2050–5. doi: 10.1016/j.cub.2005.10.052 . PMID 16303566.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105254 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006095 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8978778-5] Watanabe TK, Shimizu F, Nagata M, Kawai A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Jan 1997). "Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain". Cytogenet Cell Genet. 72 (2–3): 208–11. doi:10.1159/000134191. PMID 8978778.

[entrez-6] "Entrez Gene: TBCB tubulin folding cofactor B".

[1]

[2]

[3]

[4]

[5]

[6]

TBCB

Related Research Articles

References

Further reading