TBCD

Last updated
TBCD
Identifiers
Aliases TBCD , SSD-1, tfcD, tubulin folding cofactor D, PEBAT
External IDs OMIM: 604649; MGI: 1919686; HomoloGene: 4368; GeneCards: TBCD; OMA:TBCD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033052
NM_005993

NM_029878

RefSeq (protein)

NP_005984

NP_084154

Location (UCSC) Chr 17: 82.75 – 82.95 Mb Chr 11: 121.34 – 121.51 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene. [5]

Contents

Function

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [5]

Interactions

TBCD has been shown to interact with ARL2. [6] [7]

References

  1. 1 2 3 ENSG00000141556 GRCh38: Ensembl release 89: ENSG00000278759, ENSG00000141556 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039230 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: TBCD tubulin folding cofactor D".
  6. Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (October 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42): 40829–36. doi: 10.1074/jbc.M308678200 . PMID   12912990.
  7. Bhamidipati A, Lewis SA, Cowan NJ (May 2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5): 1087–96. doi:10.1083/jcb.149.5.1087. PMC   2174823 . PMID   10831612.

Further reading