TC-O 9311

TC-O 9311

Identifiers
IUPAC name 1-[(3,5-dimethoxybenzoyl)amino]-3-naphthalen-1-ylurea
CAS Number	444932-31-4
PubChem CID	3376937
ChemSpider	2622265
ChEMBL	ChEMBL3633893
Chemical and physical data
Formula	C20H19N3O4
Molar mass	365.389 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=CC(=CC(=C1)C(=O)NNC(=O)NC2=CC=CC3=CC=CC=C32)OC
InChI InChI=1S/C20H19N3O4/c1-26-15-10-14(11-16(12-15)27-2)19(24)22-23-20(25)21-18-9-5-7-13-6-3-4-8-17(13)18/h3-12H,1-2H3,(H,22,24)(H2,21,23,25) Key:KPTMSQHTGZMEFU-UHFFFAOYSA-N

TC-O 9311 is a chemical compound which acts as a small-molecule agonist of the previously orphan receptor GPR139. ^[1] It has been used to investigate the structure and function of the GPR139 receptor, and its interactions with other receptors with which it is co-expressed in the body such as the dopamine D2 receptor and the melanocortin receptors. ^{[2] [3] [4]}

References

1. Dvorak CA, Coate H, Nepomuceno D, Wennerholm M, Kuei C, Lord B, et al. (September 2015). "Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor". ACS Medicinal Chemistry Letters. 6 (9): 1015–1018. doi:10.1021/acsmedchemlett.5b00247. PMC   4569879 . PMID   26396690.
2. Nepomuceno D, Kuei C, Dvorak C, Lovenberg T, Liu C, Bonaventure P (2018). "Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro". Frontiers in Pharmacology. 9 157. doi: 10.3389/fphar.2018.00157 . PMC   5863515 . PMID   29599718.
3. Wang L, Lee G, Shih A, Kuei C, Nepomuceno D, Wennerholm M, et al. (February 2019). "Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors". Pharmacology Research & Perspectives. 7 (1) e00466. doi:10.1002/prp2.466. PMC   6367278 . PMID   30774960.
4. Wang L, Lee G, Kuei C, Yao X, Harrington A, Bonaventure P, et al. (2019). "GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact". Frontiers in Neuroscience. 13 281. doi: 10.3389/fnins.2019.00281 . PMC   6443882 . PMID   30971885.