TCF20

TCF20
Identifiers
Aliases	TCF20 , AR1, SPBP, TCF-20, transcription factor 20 (AR1), transcription factor 20, DDVIBA
External IDs	OMIM: 603107 MGI: 108399 HomoloGene: 4131 GeneCards: TCF20
Gene location (Human)
Chr.	Chromosome 22 (human)
End	42,343,616 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	82,987,872 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding ; • GO:0001105 transcription coactivator activity ; • metal ion binding ; • RNA binding ; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity ; • GO:0001948 protein binding ;
Cellular component	• nucleoplasm ; • nuclear body ; • nucleus ;
Biological process	• regulation of transcription, DNA-templated ; • transcription, DNA-templated ; • positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	6942
	21411
ENSG00000283681 ; ENSG00000281897 ; ENSG00000262024 ; ENSG00000282892 ; ENSG00000283026 ;
	ENSG00000280467 ; ENSG00000100207 ; ENSG00000276461
	ENSMUSG00000041852
	Q9UGU0
	Q9EPQ8
	NM_005650 ; NM_181492 ; NM_001378418
	NM_001114140 ; NM_013836
	NP_005641 ; NP_852469 ; NP_001365347
	NP_001107612 ; NP_038864
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 22, 2021

Transcription factor 20 is a protein that in humans is encoded by the TCF20 gene.^[5]^[6]^[7]

The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.^[7]

Interactions

TCF20 has been shown to interact with RNF4.^[8]

Related Research Articles

Transcription factor 3, also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 expression.

CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor -like 1" which has an official symbol of NFE2L1.

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.

Transcription factor 12 is a protein that in humans is encoded by the TCF12 gene.

Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene.

D site of albumin promoter binding protein, also known as DBP, is a protein which in humans is encoded by the DBP gene.

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.

RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene.

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.

Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.

Single-stranded DNA-binding protein, mitochondrial is a protein that in humans is encoded by the SSBP1 gene.

CAMP responsive element binding protein-like 1, also known as CREBL1, is a protein which in humans is encoded by the CREBL1 gene.

E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.

POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.

Kruppel-like factor 7 (ubiquitous), also known as KLF7, is a protein which in humans is encoded by the KLF7 gene.

Transcription factor 15 is a protein that in humans is encoded by the TCF15 gene.

References

1 2 3 ENSG00000281897, ENSG00000262024, ENSG00000282892, ENSG00000283026, ENSG00000280467, ENSG00000100207, ENSG00000276461 GRCh38: Ensembl release 89: ENSG00000283681, ENSG00000281897, ENSG00000262024, ENSG00000282892, ENSG00000283026, ENSG00000280467, ENSG00000100207, ENSG00000276461 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041852 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rajadhyaksha A, Rivière M, Van Vooren P, Szpirer J, Szpirer C, Babin J, Bina M (October 1998). "Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization". Cytogenetics and Cell Genetics. 81 (3–4): 176–7. doi:10.1159/000015021. PMID 9730594. S2CID 46832690.
↑ Rekdal C, Sjøttem E, Johansen T (December 2000). "The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators". The Journal of Biological Chemistry. 275 (51): 40288–300. doi: 10.1074/jbc.M006978200 . PMID 10995766.
1 2 "Entrez Gene: TCF20 transcription factor 20 (AR1)".
↑ Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (August 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–9. doi: 10.1074/jbc.M003405200 . PMID 10849425.

Sanz L, Moscat J, Diaz-Meco MT (June 1995). "Molecular characterization of a novel transcription factor that controls stromelysin expression". Molecular and Cellular Biology. 15 (6): 3164–70. doi:10.1128/mcb.15.6.3164. PMC 230548 . PMID 7760812.
Kirstein M, Sanz L, Quiñones S, Moscat J, Diaz-Meco MT, Saus J (July 1996). "Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene". The Journal of Biological Chemistry. 271 (30): 18231–6. doi: 10.1074/jbc.271.30.18231 . PMID 8663478.
Ohara O, Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Nomura N (February 1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins". DNA Research. 4 (1): 53–9. CiteSeerX 10.1.1.325.2199 . doi:10.1093/dnares/4.1.53. PMID 9179496.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (August 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–9. doi: 10.1074/jbc.M003405200 . PMID 10849425.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Gburcik V, Bot N, Maggiolini M, Picard D (May 2005). "SPBP is a phosphoserine-specific repressor of estrogen receptor alpha". Molecular and Cellular Biology. 25 (9): 3421–30. doi:10.1128/MCB.25.9.3421-3430.2005. PMC 1084313 . PMID 15831449.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.
Sjøttem E, Rekdal C, Svineng G, Johnsen SS, Klenow H, Uglehus RD, Johansen T (2007). "The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription". Nucleic Acids Research. 35 (19): 6648–62. doi:10.1093/nar/gkm739. PMC 2095823 . PMID 17913746.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000281897, ENSG00000262024, ENSG00000282892, ENSG00000283026, ENSG00000280467, ENSG00000100207, ENSG00000276461 GRCh38: Ensembl release 89: ENSG00000283681, ENSG00000281897, ENSG00000262024, ENSG00000282892, ENSG00000283026, ENSG00000280467, ENSG00000100207, ENSG00000276461 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041852 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9730594-5] Rajadhyaksha A, Rivière M, Van Vooren P, Szpirer J, Szpirer C, Babin J, Bina M (October 1998). "Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization". Cytogenetics and Cell Genetics. 81 (3–4): 176–7. doi:10.1159/000015021. PMID 9730594. S2CID 46832690.

[pmid10995766-6] Rekdal C, Sjøttem E, Johansen T (December 2000). "The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators". The Journal of Biological Chemistry. 275 (51): 40288–300. doi: 10.1074/jbc.M006978200 . PMID 10995766.

[entrez-7] 1 2 "Entrez Gene: TCF20 transcription factor 20 (AR1)".

[pmid10849425-8] Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (August 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–9. doi: 10.1074/jbc.M003405200 . PMID 10849425.

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TCF20

Contents

Interactions

Related Research Articles

References

Further reading