TCF20

TCF20
Identifiers
Aliases	TCF20 , AR1, SPBP, TCF-20, transcription factor 20 (AR1), transcription factor 20, DDVIBA
External IDs	OMIM: 603107; MGI: 108399; HomoloGene: 4131; GeneCards: TCF20; OMA:TCF20 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.2|22q13.3 Start 42,160,013 bp [1] End 42,343,616 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 82,692,637 bp [2] End 82,872,073 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence bone marrow cells islet of Langerhans tonsil mucosa of esophagus blood granulocyte lymph node olfactory zone of nasal mucosa superior frontal gyrus Top expressed in Rostral migratory stream genital tubercle tail of embryo dentate gyrus of hippocampal formation granule cell secondary oocyte olfactory tubercle ciliary body dorsal striatum conjunctival fornix supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity metal ion binding RNA binding DNA-binding transcription factor activity protein binding Cellular component nucleoplasm nuclear body nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6942 21411 Ensembl ENSG00000283681 ENSG00000281897 ENSG00000262024 ENSG00000282892 ENSG00000283026 ENSG00000280467 ENSG00000100207 ENSG00000276461 ENSMUSG00000041852 UniProt Q9UGU0 Q9EPQ8 RefSeq (mRNA) NM_005650 NM_181492 NM_001378418 NM_001114140 NM_013836 RefSeq (protein) NP_005641 NP_852469 NP_001365347 NP_001107612 NP_038864 NP_001389767 Location (UCSC) Chr 22: 42.16 – 42.34 Mb Chr 15: 82.69 – 82.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor 20 is a protein that in humans is encoded by the TCF20 gene. ^{[5] [6] [7]}

The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms. ^[7]

Interactions

TCF20 has been shown to interact with RNF4. ^[8]

References

1. ENSG00000281897, ENSG00000262024, ENSG00000282892, ENSG00000283026, ENSG00000280467, ENSG00000100207, ENSG00000276461 GRCh38: Ensembl release 89: ENSG00000283681, ENSG00000281897, ENSG00000262024, ENSG00000282892, ENSG00000283026, ENSG00000280467, ENSG00000100207, ENSG00000276461 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041852 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rajadhyaksha A, Rivière M, Van Vooren P, Szpirer J, Szpirer C, Babin J, Bina M (October 1998). "Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization". Cytogenetics and Cell Genetics. 81 (3–4): 176–7. doi:10.1159/000015021. PMID   9730594. S2CID   46832690.
6. Rekdal C, Sjøttem E, Johansen T (December 2000). "The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators". The Journal of Biological Chemistry. 275 (51): 40288–300. doi: 10.1074/jbc.M006978200 . PMID   10995766.
7. "Entrez Gene: TCF20 transcription factor 20 (AR1)".
8. Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (August 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–9. doi: 10.1074/jbc.M003405200 . PMID   10849425.

Further reading

• Sanz L, Moscat J, Diaz-Meco MT (June 1995). "Molecular characterization of a novel transcription factor that controls stromelysin expression". Molecular and Cellular Biology. 15 (6): 3164–70. doi:10.1128/mcb.15.6.3164. PMC   230548 . PMID   7760812.
• Kirstein M, Sanz L, Quiñones S, Moscat J, Diaz-Meco MT, Saus J (July 1996). "Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene". The Journal of Biological Chemistry. 271 (30): 18231–6. doi: 10.1074/jbc.271.30.18231 . PMID   8663478.
• Ohara O, Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Nomura N (February 1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins". DNA Research. 4 (1): 53–9. CiteSeerX   10.1.1.325.2199 . doi:10.1093/dnares/4.1.53. PMID   9179496.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (August 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–9. doi: 10.1074/jbc.M003405200 . PMID   10849425.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Gburcik V, Bot N, Maggiolini M, Picard D (May 2005). "SPBP is a phosphoserine-specific repressor of estrogen receptor alpha". Molecular and Cellular Biology. 25 (9): 3421–30. doi:10.1128/MCB.25.9.3421-3430.2005. PMC   1084313 . PMID   15831449.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Sjøttem E, Rekdal C, Svineng G, Johnsen SS, Klenow H, Uglehus RD, Johansen T (2007). "The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription". Nucleic Acids Research. 35 (19): 6648–62. doi:10.1093/nar/gkm739. PMC   2095823 . PMID   17913746.