RNF4

RNF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EA6, 2XEU, 4PPE
Identifiers
Aliases	RNF4 , SLX5, SNURF, RES4-26, ring finger protein 4
External IDs	OMIM: 602850; MGI: 1201691; HomoloGene: 37711; GeneCards: RNF4; OMA:RNF4 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p16.3 Start 2,462,220 bp [1] End 2,625,320 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B2 Start 34,493,633 bp [2] End 34,512,973 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus oocyte middle temporal gyrus epithelium of colon tonsil secondary oocyte bone marrow cell lymph node beta cell stromal cell of endometrium Top expressed in seminiferous tubule zygote lactiferous gland cumulus cell Ileal epithelium secondary oocyte ankle joint yolk sac spermatid epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding ubiquitin protein ligase activity DNA-binding transcription factor activity transcription coactivator activity metal ion binding ubiquitin-protein transferase activity protein binding androgen receptor binding identical protein binding nucleosome binding transferase activity transcription factor binding SUMO polymer binding zinc ion binding nuclear receptor coactivator activity Cellular component cytoplasm PML body nucleoplasm nucleus Biological process androgen receptor signaling pathway regulation of transcription, DNA-templated protein K63-linked ubiquitination response to arsenic-containing substance transcription, DNA-templated positive regulation of transcription, DNA-templated protein K11-linked ubiquitination regulation of kinetochore assembly protein K48-linked ubiquitination protein K6-linked ubiquitination protein ubiquitination regulation of spindle assembly positive regulation of transcription by RNA polymerase II proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6047 19822 Ensembl ENSG00000063978 ENSMUSG00000029110 UniProt P78317 Q9QZS2 RefSeq (mRNA) NM_002938 NM_001185009 NM_001185010 NM_011278 NM_001304269 NM_001304270 RefSeq (protein) NP_001171938 NP_001171939 NP_002929 NP_001291198 NP_001291199 NP_035408 Location (UCSC) Chr 4: 2.46 – 2.63 Mb Chr 5: 34.49 – 34.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene. ^{[5] [6]}

The protein encoded by this gene contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. ^[6]

Interactions

RNF4 has been shown to interact with TCF20, ^[7] PATZ1 ^{[8] [9]} and Androgen receptor. ^{[9] [10] [11]} RNF4 has been shown to be responsible for the degradation of the Werner syndrome helicase in MSI-H cells after WRN inhibition. ^[12]

See also

• RING finger domain

References

1. GRCh38: Ensembl release 89: ENSG00000063978 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029110 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chiariotti L, Benvenuto G, Fedele M, Santoro M, Simeone A, Fusco A, et al. (January 1998). "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3". Genomics. 47 (2): 258–265. doi:10.1006/geno.1997.5105. PMID   9479498.
6. "Entrez Gene: RNF4 ring finger protein 4".
7. Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, et al. (August 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–26149. doi: 10.1074/jbc.M003405200 . PMID   10849425.
8. Fedele M, Benvenuto G, Pero R, Majello B, Battista S, Lembo F, et al. (March 2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor". The Journal of Biological Chemistry. 275 (11): 7894–7901. doi: 10.1074/jbc.275.11.7894 . PMID   10713105.
9. Pero R, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A, et al. (February 2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription". The Journal of Biological Chemistry. 277 (5): 3280–3285. doi: 10.1074/jbc.M109491200 . PMID   11719514.
10. Moilanen AM, Poukka H, Karvonen U, Häkli M, Jänne OA, Palvimo JJ (September 1998). "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription". Molecular and Cellular Biology. 18 (9): 5128–5139. doi:10.1128/mcb.18.9.5128. PMC   109098 . PMID   9710597.
11. Poukka H, Aarnisalo P, Santti H, Jänne OA, Palvimo JJ (January 2000). "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms". The Journal of Biological Chemistry. 275 (1): 571–579. doi: 10.1074/jbc.275.1.571 . PMID   10617653.
12. Rodríguez Pérez F, Natwick D, Schiff L, McSwiggen D, Heckert A, Huey M, et al. (July 2024). "WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis". Nature Communications. 15 (1) 6059. Bibcode:2024NatCo..15.6059R. doi: 10.1038/s41467-024-50178-3 . PMC   11258360 . PMID   39025847.

Further reading

• Moilanen AM, Poukka H, Karvonen U, Häkli M, Jänne OA, Palvimo JJ (September 1998). "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription". Molecular and Cellular Biology. 18 (9): 5128–5139. doi:10.1128/mcb.18.9.5128. PMC   109098 . PMID   9710597.
• Hadano S, Ishida Y, Ikeda JE (June 1998). "The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3". DNA Research. 5 (3): 177–186. doi: 10.1093/dnares/5.3.177 . PMID   9734812.
• Poukka H, Aarnisalo P, Santti H, Jänne OA, Palvimo JJ (January 2000). "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms". The Journal of Biological Chemistry. 275 (1): 571–579. doi: 10.1074/jbc.275.1.571 . PMID   10617653.
• Fedele M, Benvenuto G, Pero R, Majello B, Battista S, Lembo F, et al. (March 2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor". The Journal of Biological Chemistry. 275 (11): 7894–7901. doi: 10.1074/jbc.275.11.7894 . PMID   10713105.
• Galili N, Nayak S, Epstein JA, Buck CA (May 2000). "Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region". Developmental Dynamics. 218 (1): 102–111. doi: 10.1002/(SICI)1097-0177(200005)218:1<102::AID-DVDY9>3.0.CO;2-A . PMID   10822263.
• Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, et al. (August 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–26149. doi: 10.1074/jbc.M003405200 . PMID   10849425.
• Häkli M, Karvonen U, Jänne OA, Palvimo JJ (June 2001). "The RING finger protein SNURF is a bifunctional protein possessing DNA binding activity". The Journal of Biological Chemistry. 276 (26): 23653–23660. doi: 10.1074/jbc.M009891200 . PMID   11319220.
• Saville B, Poukka H, Wormke M, Janne OA, Palvimo JJ, Stoner M, et al. (January 2002). "Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein". The Journal of Biological Chemistry. 277 (4): 2485–2497. doi: 10.1074/jbc.M109021200 . PMID   11696545.
• Pero R, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A, et al. (February 2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription". The Journal of Biological Chemistry. 277 (5): 3280–3285. doi: 10.1074/jbc.M109491200 . PMID   11719514.
• Yan W, Hirvonen-Santti SJ, Palvimo JJ, Toppari J, Jänne OA (October 2002). "Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation". Mechanisms of Development. 118 (1–2): 247–253. doi: 10.1016/S0925-4773(02)00261-7 . PMID   12351196. S2CID   15579434.
• Pero R, Lembo F, Chieffi P, Del Pozzo G, Fedele M, Fusco A, et al. (September 2003). "Translational regulation of a novel testis-specific RNF4 transcript". Molecular Reproduction and Development. 66 (1): 1–7. doi:10.1002/mrd.10322. PMID   12874792. S2CID   6206480.
• Kaiser FJ, Möröy T, Chang GT, Horsthemke B, Lüdecke HJ (October 2003). "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor". The Journal of Biological Chemistry. 278 (40): 38780–38785. doi: 10.1074/jbc.M306259200 . PMID   12885770.
• Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, et al. (December 2004). "Negative modulation of androgen receptor transcriptional activity by Daxx". Molecular and Cellular Biology. 24 (24): 10529–10541. doi:10.1128/MCB.24.24.10529-10541.2004. PMC   533990 . PMID   15572661.

External links

• RNF4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)