TCIM

TCIM
Identifiers
Aliases	TCIM , TC-1, TC1, C8orf4, chromosome 8 open reading frame 4, transcriptional and immune response regulator
External IDs	OMIM: 607702; MGI: 1916318; HomoloGene: 10590; GeneCards: TCIM; OMA:TCIM - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p11.21 Start 40,153,482 bp [1] End 40,155,310 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A2 Start 24,927,196 bp [2] End 24,929,000 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland gallbladder right lung vena cava mucosa of urinary bladder seminal vesicula upper lobe of left lung pericardium visceral pleura rectum Top expressed in parotid gland lacrimal gland left lung lobe interventricular septum seminal vesicula molar olfactory epithelium epithelium of small intestine intestinal villus brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Notch binding Cellular component cytoplasm nuclear speck nucleolus nucleus nucleoplasm cytosol plasma membrane intracellular anatomical structure Biological process regulation of cell cycle G1/S phase transition endothelial cell activation involved in immune response cellular response to heat regulation of DNA-templated transcription in response to stress regulation of hemopoiesis negative regulation of Notch signaling pathway apoptotic process positive regulation of protein kinase A signaling negative regulation of apoptotic process positive regulation of protein kinase C activity positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56892 69068 Ensembl ENSG00000176907 ENSMUSG00000056313 UniProt Q9NR00 Q9D915 RefSeq (mRNA) NM_020130 NM_026931 RefSeq (protein) NP_064515 NP_081207 Location (UCSC) Chr 8: 40.15 – 40.16 Mb Chr 8: 24.93 – 24.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TCIM is a protein that in humans is encoded by the TCIM gene. ^{[5] [6]}

Function

This gene encodes a small, monomeric, predominantly unstructured protein (106 amino acids, 12.3 kDa, isoelectric point 9.39). ^[7] It is a positive regulator of the Wnt / beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000176907 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056313 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chua EL, Young L, Wu WM, Turtle JR, Dong Q (November 2000). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer". Genomics. 69 (3): 342–7. doi:10.1006/geno.2000.6348. PMID   11056052.
6. "Entrez Gene: C8orf4 chromosome 8 open reading frame 4".
7. Kozlowski LP (October 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi: 10.1186/s13062-016-0159-9 . PMC   5075173 . PMID   27769290.

Further reading

• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP, Death AK (April 2004). "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer". Cancer Research. 64 (8): 2766–73. doi:10.1158/0008-5472.CAN-03-2093. PMID   15087392.
• Friedman JB, Brunschwig EB, Platzer P, Wilson K, Markowitz SD (August 2004). "C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer". International Journal of Cancer. 111 (1): 72–5. doi:10.1002/ijc.20235. PMID   15185345. S2CID   19983783.
• Jung Y, Bang S, Choi K, Kim E, Kim Y, Kim J, Park J, Koo H, Moon RT, Song K, Lee I (January 2006). "TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby" (PDF). Cancer Research. 66 (2): 723–8. doi: 10.1158/0008-5472.CAN-05-3124 . PMID   16424001.
• Kim B, Koo H, Yang S, Bang S, Jung Y, Kim Y, Kim J, Park J, Moon RT, Song K, Lee I (June 2006). "TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer". Clinical Cancer Research. 12 (11 Pt 1): 3541–8. doi: 10.1158/1078-0432.CCR-05-2440 . PMID   16740781.
• Yang ZQ, Streicher KL, Ray ME, Abrams J, Ethier SP (December 2006). "Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer". Cancer Research. 66 (24): 11632–43. doi: 10.1158/0008-5472.CAN-06-2946 . PMID   17178857.
• Yang ZQ, Moffa AB, Haddad R, Streicher KL, Ethier SP (September 2007). "Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways". International Journal of Cancer. 121 (6): 1265–73. doi: 10.1002/ijc.22831 . PMID   17520678. S2CID   25292320.
• Park J, Jung Y, Kim J, Kim KY, Ahn SG, Song K, Lee I (August 2007). "TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response". Biochemical and Biophysical Research Communications. 360 (2): 447–52. doi:10.1016/j.bbrc.2007.06.077. PMID   17603013.

External links

• Human C8orf4 genome location and C8orf4 gene details page in the UCSC Genome Browser .