TEX10

TEX10
Identifiers
Aliases	TEX10 , Ipi1, bA208F1.2, testis expressed 10
External IDs	OMIM: 616717 MGI: 1344413 HomoloGene: 32361 GeneCards: TEX10
Gene location (Human)
Chr.	Chromosome 9 (human)
End	100,352,942 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	48,473,459 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; sperm; ; Achilles tendon; ; endothelial cell; ; gastrocnemius muscle; ; placenta; ; tibia; ; tibialis anterior muscle; ; stromal cell of endometrium; ; skin of abdomen;
	Top expressed in
	primitive streak; ; internal carotid artery; ; external carotid artery; ; abdominal wall; ; ureter; ; ectoderm; ; otic placode; ; maxillary prominence; ; medullary collecting duct; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; MLL1 complex ; nucleolus ; nucleus ; Rix1 complex ; nucleoplasm ;
Biological process	rRNA processing ;
	Sources:Amigo / QuickGO
Orthologs
	54881
	269536
	ENSG00000136891
	ENSMUSG00000028345
	Q9NXF1
	Q3URQ0
	NM_001161584 ; NM_017746
	NM_172304 ; NM_001355740 ; NM_001355741
	NP_001155056 ; NP_060216 ; NP_060216.2
	NP_758508 ; NP_001342669 ; NP_001342670
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Testis-expressed sequence 10 protein is a protein that in humans is encoded by the TEX10 gene.^[5]^[6]

TEX10 forms part of a complex with WDR18, LAS1L called the rixosome that participates in RNA degradation, ribosomal RNA (rRNA) processing and ribosome biogenesis.^[7]

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<span class="mw-page-title-main">DDX50</span>

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The rixosome is a protein complex named after the S. cerevisiae gene RIX1 involved in RNA degradation, ribosomal RNA (rRNA) processing and ribosome biogenesis. The rixosome associates with human PRC1 and PRC2 complexes. The interaction with PRC1 appears to be through the RING1B domain of PRC1 based on mutational analysis. The colocalization of the risoxome and PRC complex suggest a role in rixosomal degradation of nascent RNA to contributes to silencing of many Polycomb targets in human cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136891 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028345 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
↑ "Entrez Gene: TEX10 testis expressed sequence 10".
↑ Castle CD, Cassimere EK, Denicourt C (February 2012). "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell. 23 (4): 716–728. doi:10.1091/mbc.E11-06-0530. PMC 3279398 . PMID 22190735.

^[1]

Ohira M, Morohashi A, Nakamura Y, Isogai E, Furuya K, Hamano S, et al. (July 2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Letters. 197 (1–2): 63–68. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, et al. (October 2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–7745. doi: 10.1038/sj.onc.1207921 . PMID 15334068.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, et al. (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–4109. doi:10.1091/mbc.E02-05-0271. PMC 133617 . PMID 12429849.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

↑ Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D (June 2020). "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife. 9. doi:10.7554/eLife.54341. PMC 7269676 . PMID 32491985.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136891 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028345 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

[entrez-6] "Entrez Gene: TEX10 testis expressed sequence 10".

[pmid22190735-7] Castle CD, Cassimere EK, Denicourt C (February 2012). "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell. 23 (4): 716–728. doi:10.1091/mbc.E11-06-0530. PMC 3279398 . PMID 22190735.

[pmid32491985-8] Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D (June 2020). "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife. 9. doi:10.7554/eLife.54341. PMC 7269676 . PMID 32491985.

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TEX10

Related Research Articles

References

Further reading