WD repeat domain 18

WDR18
Identifiers
Aliases	WDR18 , Ipi3, R32184_1, WD repeat domain 18
External IDs	MGI: 2158400 HomoloGene: 32573 GeneCards: WDR18
Gene location (Human)
Chr.	Chromosome 19 (human)
End	998,438 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,806,037 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; anterior pituitary; ; left adrenal gland; ; right lobe of thyroid gland; ; ganglionic eminence; ; stromal cell of endometrium; ; skin of abdomen; ; cingulate gyrus; ; left lobe of thyroid gland; ; nucleus accumbens;
	Top expressed in
	morula; ; hand; ; spermatid; ; spermatocyte; ; neural tube; ; yolk sac; ; blastocyst; ; superior frontal gyrus; ; proximal tubule; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	nucleus ; cytoplasm ; nucleoplasm ; nucleolus ; nuclear pre-replicative complex ; Rix1 complex ;
Biological process	multicellular organism development ; rRNA processing ; ribosomal large subunit assembly ; pre-replicative complex assembly involved in nuclear cell cycle DNA replication ; regulation of DNA-dependent DNA replication initiation ;
	Sources:Amigo / QuickGO
Orthologs
	57418
	216156
	ENSG00000065268
	ENSMUSG00000035754
	Q9BV38
	Q4VBE8
	NM_024100 ; NM_001372085 ; NM_001372086
	NM_175450
	NP_077005 ; NP_001359014 ; NP_001359015
	NP_780659
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 30, 2023

WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene. ^[5]

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR18 forms a nucleolar complex with LAS1L, PELP1, TEX10 called the rixosome which is involved in RNA degradation.^[6]^[7] The rixosome is a nucleolar complex that cofractionates with the 60S preribosomal subunit. Recruitment of the rixosome by the Polycomb Repressive Complex 1 has been proposed to lead to its functioning in establishing repressive chromatin structures by assisting in degrading nascent RNA.^[8]

Related Research Articles

Polyhomeotic-like protein 1 is a protein that in humans is encoded by the PHC1 gene.

WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene.

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WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene.

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.

Nucleolar protein 6 is a protein that in humans is encoded by the NOL6 gene.

tRNA -methyltransferase subunit WDR4 is an enzyme subunit that in humans is encoded by the WDR4 gene.

WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.

WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene.

WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) is a protein that in humans is encoded by the WDR45 gene. Mutations in this gene cause a distinct form of Neurodegeneration with brain iron accumulation (NBIA) called Beta-propeller protein-associated neurodegeneration (BPAN).

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.

Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the BRWD1 gene.

Testis-expressed sequence 10 protein is a protein that in humans is encoded by the TEX10 gene.

WD repeat-containing protein 11 (WDR11) also known as bromodomain and WD repeat-containing protein 2 (BRWD2) is a protein that in humans is encoded by the WDR11 gene.

WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa, is a protein that in humans is encoded by the WIPI1 gene.

WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like is a protein that in humans is encoded by the gene.

The human KDM2B gene encodes the protein lysine (K)-specific demethylase 2B.

WD repeat domain 83 is a protein that in humans is encoded by the WDR83 gene.

The rixosome is a protein complex involved in RNA degradation, ribosomal RNA (rRNA) processing, and ribosome biogenesis. It was named after the S. cerevisiae gene RIX1. The rixosome is associated with human PRC1 and PRC2 complexes. The interaction with PRC1 appears to be through the RING1B domain of PRC1 based on mutational analysis. The co-localization of the rixosome and PRC complex suggest a role in the rixosomal degradation of nascent RNA to contribute to the silencing of many Polycomb targets in human cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000065268 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035754 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: WD repeat domain 18" . Retrieved 2017-08-12.
↑ Castle CD, Cassimere EK, Denicourt C (February 2012). "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell. 23 (4): 716–728. doi:10.1091/mbc.E11-06-0530. PMC 3279398 . PMID 22190735.
↑ Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D (June 2020). "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife. 9. doi: 10.7554/eLife.54341 . PMC 7269676 . PMID 32491985.
↑ Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, et al. (April 2022). "Rixosomal RNA degradation contributes to silencing of Polycomb target genes". Nature. 604 (7904): 167–174. Bibcode:2022Natur.604..167Z. doi:10.1038/s41586-022-04598-0. PMC 8986528 . PMID 35355014.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000065268 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035754 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: WD repeat domain 18" . Retrieved 2017-08-12.

[pmid22190735-6] Castle CD, Cassimere EK, Denicourt C (February 2012). "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell. 23 (4): 716–728. doi:10.1091/mbc.E11-06-0530. PMC 3279398 . PMID 22190735.

[pmid32491985-7] Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D (June 2020). "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife. 9. doi: 10.7554/eLife.54341 . PMC 7269676 . PMID 32491985.

[pmid35355014-8] Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, et al. (April 2022). "Rixosomal RNA degradation contributes to silencing of Polycomb target genes". Nature. 604 (7904): 167–174. Bibcode:2022Natur.604..167Z. doi:10.1038/s41586-022-04598-0. PMC 8986528 . PMID 35355014.

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