TFDP2

TFDP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CF7
Identifiers
Aliases	TFDP2 , DP2, transcription factor Dp-2
External IDs	OMIM: 602160; MGI: 107167; HomoloGene: 4578; GeneCards: TFDP2; OMA:TFDP2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q23 Start 141,944,428 bp [1] End 142,149,544 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 E3.3 Start 96,196,275 bp [2] End 96,323,646 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon left testis right testis ventricular zone bone marrow cells thymus ganglionic eminence gonad epithelium of colon olfactory zone of nasal mucosa Top expressed in blood otic vesicle myocardium of ventricle tibialis anterior muscle interventricular septum hand tail of embryo vastus lateralis muscle genital tubercle Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding transcription factor binding protein binding transcription coregulator activity protein domain specific binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex nucleoplasm mitochondrion RNA polymerase II transcription regulator complex Biological process regulation of transcription by RNA polymerase II cell cycle negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated mitotic cell cycle DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest heart development transcription, DNA-templated positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of transcription involved in G1/S transition of mitotic cell cycle transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of G0 to G1 transition regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7029 211586 Ensembl ENSG00000114126 ENSMUSG00000032411 UniProt Q14188 Q64163 RefSeq (mRNA) NM_001178138 NM_001178139 NM_001178140 NM_001178141 NM_001178142 NM_006286 NM_001375756 NM_001375773 NM_001375774 NM_001375775 NM_001375776 NM_001375778 NM_001375779 NM_001375780 NM_001184706 NM_001184708 NM_001184709 NM_001184710 NM_001184711 NM_178667 RefSeq (protein) NP_001171609 NP_001171610 NP_001171611 NP_001171612 NP_001171613 NP_006277 NP_001362685 NP_001362702 NP_001362703 NP_001362704 NP_001362705 NP_001362707 NP_001362708 NP_001362709 n/a Location (UCSC) Chr 3: 141.94 – 142.15 Mb Chr 9: 96.2 – 96.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene that dimerises with E2F, a key transcriptional activator involved in the regulation of the cell cycle. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000114126 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032411 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang Y, Chellappan SP (Jul 1995). "Cloning and characterization of human DP2, a novel dimerization partner of E2F". Oncogene. 10 (11): 2085–93. PMID   7784053.
6. Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics. 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID   9027491.
7. "Entrez Gene: TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)".

Further reading

• Wu CL, Zukerberg LR, Ngwu C, et al. (1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC   230484 . PMID   7739537.
• Rogers KT, Higgins PD, Milla MM, et al. (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. Bibcode:1996PNAS...93.7594R. doi: 10.1073/pnas.93.15.7594 . PMC   38791 . PMID   8755520.
• Loiseau L, Pasteau S, Brun G (1998). "Molecular cloning and expression pattern of the DP members of the chicken E2F transcription factor". Gene Expr. 6 (5): 259–73. PMC   6148286 . PMID   9368098.
• Trimarchi JM, Fairchild B, Verona R, et al. (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. Bibcode:1998PNAS...95.2850T. doi: 10.1073/pnas.95.6.2850 . PMC   19658 . PMID   9501179.
• Gaubatz S, Wood JG, Livingston DM (1998). "Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9190–5. Bibcode:1998PNAS...95.9190G. doi: 10.1073/pnas.95.16.9190 . PMC   21314 . PMID   9689056.
• Zheng N, Fraenkel E, Pabo CO, Pavletich NP (1999). "Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F–DP". Genes Dev. 13 (6): 666–74. doi:10.1101/gad.13.6.666. PMC   316551 . PMID   10090723.
• Korz C, Pscherer A, Benner A, et al. (2002). "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood. 99 (12): 4554–61. doi: 10.1182/blood.V99.12.4554 . PMID   12036888.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Park KK, Deok Ahn J, Lee IK, et al. (2003). "Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP". Biochem. Biophys. Res. Commun. 308 (4): 689–97. doi:10.1016/S0006-291X(03)01455-4. PMID   12927774.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• Overview of all the structural information available in the PDB for UniProt : Q14188 (Transcription factor Dp-2) at the PDBe-KB .