TGIF2

TGIF2
Identifiers
Aliases	TGIF2 , TGFB induced factor homeobox 2
External IDs	OMIM: 607294 MGI: 1915299 HomoloGene: 32514 GeneCards: TGIF2
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.23 Start 36,573,488 bp [1] End 36,593,950 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 156,681,927 bp [2] End 156,697,490 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in embryo ganglionic eminence sural nerve right uterine tube monocyte oocyte lymph node secondary oocyte smooth muscle tissue ovary Top expressed in phalanx of finger thumb maxillary prominence neural tube index finger little finger ganglionic eminence secondary oocyte female urethra mirror More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II retina development in camera-type eye regulation of gastrulation positive regulation of neuron differentiation nodal signaling pathway transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60436 228839 Ensembl ENSG00000118707 ENSMUSG00000062175 UniProt Q9GZN2 Q8C0Y1 RefSeq (mRNA) NM_021809 NM_001199513 NM_001199514 NM_001199515 NM_001291124 NM_173396 RefSeq (protein) NP_001186442 NP_001186443 NP_001186444 NP_068581 NP_001278053 NP_775572 Location (UCSC) Chr 20: 36.57 – 36.59 Mb Chr 2: 156.68 – 156.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene. ^{[5] [6]}

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000118707 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062175 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Imoto I, Pimkhaokham A, Watanabe T, Saito-Ohara F, Soeda E, Inazawa J (Oct 2000). "Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines". Biochem Biophys Res Commun. 276 (1): 264–70. doi:10.1006/bbrc.2000.3449. PMID   11006116.
6. "Entrez Gene: TGIF2 TGFB-induced factor homeobox 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Melhuish TA, Gallo CM, Wotton D (2001). "TGIF2 interacts with histone deacetylase 1 and represses transcription". J. Biol. Chem. 276 (34): 32109–14. doi: 10.1074/jbc.M103377200 . PMID   11427533.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Watanabe T, Imoto I, Katahira T, et al. (2003). "Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers". Jpn. J. Cancer Res. 93 (10): 1114–22. doi:10.1111/j.1349-7006.2002.tb01213.x. PMC   5926887 . PMID   12417041.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.