TIMM17A

TIMM17A
Identifiers
Aliases	TIMM17A , TIM17, TIM17A, translocase of inner mitochondrial membrane 17 homolog A (yeast), translocase of inner mitochondrial membrane 17A
External IDs	OMIM: 605057; MGI: 1343131; HomoloGene: 115910; GeneCards: TIMM17A; OMA:TIMM17A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 201,955,503 bp [1] End 201,970,664 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 135,295,213 bp [2] End 135,313,778 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 right ventricle biceps brachii middle temporal gyrus endothelial cell orbitofrontal cortex amniotic fluid Skeletal muscle tissue of biceps brachii myocardium of left ventricle Epithelium of choroid plexus Top expressed in morula morula interventricular septum soleus muscle blastocyst extraocular muscle temporal muscle cardiac muscle tissue of left ventricle masseter muscle plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-transporting ATPase activity protein transmembrane transporter activity Cellular component nucleoplasm integral component of mitochondrial inner membrane mitochondrial inner membrane integral component of membrane TIM23 mitochondrial import inner membrane translocase complex mitochondrion membrane Biological process protein targeting to mitochondrion protein import into mitochondrial matrix protein transport intracellular protein transport positive regulation of protein processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10440 21854 Ensembl ENSG00000134375 ENSMUSG00000062580 UniProt Q99595 Q9Z0V8 RefSeq (mRNA) NM_006335 NM_011590 RefSeq (protein) NP_006326 NP_035720 NP_001347786 NP_001347787 Location (UCSC) Chr 1: 201.96 – 201.97 Mb Chr 1: 135.3 – 135.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim17-A is an enzyme that in humans is encoded by the TIMM17A gene. ^{[5] [6] [7]}

See also

• Mitochondria Inner Membrane Translocase
• TIMM22
• TIMM23
• TIMM44

References

1. GRCh38: Ensembl release 89: ENSG00000134375 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062580 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bomer U, Rassow J, Zufall N, Pfanner N, Meijer M, Maarse AC (Dec 1996). "The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17". J Mol Biol. 262 (4): 389–395. doi:10.1006/jmbi.1996.0522. PMID   8893850.
6. Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz KD, Neupert W, Brunner M, Hofmann S (Jul 1999). "Genetic and structural characterization of the human mitochondrial inner membrane translocase". J Mol Biol. 289 (1): 69–82. doi:10.1006/jmbi.1999.2751. PMID   10339406.
7. "Entrez Gene: TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Piesse C, Tymms M, Garrafa E, et al. (2002). "Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression". Gene. 292 (1–2): 129–140. doi:10.1016/S0378-1119(02)00650-9. PMID   12119107.
• Moro F, Sirrenberg C, Schneider HC, et al. (1999). "The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix". EMBO J. 18 (13): 3667–3675. doi:10.1093/emboj/18.13.3667. PMC   1171444 . PMID   10393182.