TIMM22

TIMM22
Identifiers
Aliases	TIMM22 , TEX4, TIM22, translocase of inner mitochondrial membrane 22 homolog (yeast), translocase of inner mitochondrial membrane 22, COXPD43
External IDs	OMIM: 607251 MGI: 1929742 HomoloGene: 32173 GeneCards: TIMM22
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,003,671 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	76,307,118 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; islet of Langerhans; ; gastrocnemius muscle; ; placenta; ; prefrontal cortex; ; stromal cell of endometrium; ; Left adrenal gland; ; Right adrenal gland; ; skeletal muscle tissue; ; kidney;
	Top expressed in
	morula; ; facial motor nucleus; ; medial ganglionic eminence; ; endocardial cushion; ; neural tube; ; motor neuron; ; renal corpuscle; ; fossa; ; proximal tubule; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	mitochondrion targeting sequence binding ; protein binding ; protein transmembrane transporter activity ;
Cellular component	integral component of membrane ; mitochondrial inner membrane ; membrane ; mitochondrion ; TIM22 mitochondrial import inner membrane insertion complex ;
Biological process	protein transport ; protein targeting to mitochondrion ; protein insertion into mitochondrial inner membrane ; protein transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	29928
	56322
	ENSG00000277649 ; ENSG00000278501 ; ENSG00000177370
	ENSMUSG00000020843
	Q9Y584
	Q9CQ85
	NM_013337
	NM_001291161 ; NM_019818 ; NM_023355
	NP_037469
	NP_001278090 ; NP_062792 ; NP_075844
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Mitochondrial import inner membrane translocase subunit Tim22 is an enzyme that in humans is encoded by the TIMM22 gene.^[5]

Related Research Articles

Mitochondrial import inner membrane translocase subunit Tim8 A, also known as deafness-dystonia peptide or protein is an enzyme that in humans is encoded by the TIMM8A gene. This translocase has similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in deafness-dystonia syndrome and it is postulated that MTS/DFN-1 is a mitochondrial disease caused by a defective mitochondrial protein import system.

Mitochondrial inner membrane protein is a protein that in humans is encoded by the IMMT gene.)

Mitochondrial import receptor subunit TOM22 homolog is a protein that in humans is encoded by the TOMM22 gene.

Mitochondrial import inner membrane translocase subunit Tim13 is an enzyme that in humans is encoded by the TIMM13 gene.

Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene.

ATP synthase subunit b, mitochondrial is an enzyme that in humans is encoded by the ATP5PB gene.

Decaprenyl-diphosphate synthase subunit 1 is an enzyme that in humans is encoded by the PDSS1 gene.

Mitochondrial import inner membrane translocase subunit Tim10 is an enzyme that in humans is encoded by the TIMM10 gene.

Mitochondrial thiamine pyrophosphate carrier is a protein that in humans is encoded by the SLC25A19 gene.

39S ribosomal protein L11, mitochondrial is a protein that in humans is encoded by the MRPL11 gene.

Mitochondrial import inner membrane translocase subunit TIM44 is an enzyme that in humans is encoded by the TIMM44 gene.

Mitochondrial import inner membrane translocase subunit Tim9 B is an enzyme that in humans is encoded by the FXC1 gene.

Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.

39S ribosomal protein L24, mitochondrial is a protein that in humans is encoded by the MRPL24 gene.

Tetratricopeptide repeat protein 35 is a protein that in humans is encoded by the TTC35 gene.

Mitochondrial import inner membrane translocase subunit Tim23 is an enzyme that in humans is encoded by the TIMM23 gene.

Mitochondrial import inner membrane translocase subunit Tim17-A is an enzyme that in humans is encoded by the TIMM17A gene.

ATP-binding cassette sub-family B member 8, mitochondrial is a protein that in humans is encoded by the ABCB8 gene.

Mitochondrial import inner membrane translocase subunit Tim9 is an enzyme that in humans is encoded by the TIMM9 gene.

ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene.

References

1 2 3 ENSG00000278501, ENSG00000177370 GRCh38: Ensembl release 89: ENSG00000277649, ENSG00000278501, ENSG00000177370 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020843 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J. Biol. Chem. 279 (14): 13540–6. doi: 10.1074/jbc.M312485200 . PMID 14726512.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kovermann P, Truscott KN, Guiard B, et al. (2002). "Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel". Mol. Cell. 9 (2): 363–73. doi: 10.1016/S1097-2765(02)00446-X . PMID 11864609.
Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Lett. 464 (1–2): 41–7. doi: 10.1016/S0014-5793(99)01665-8 . PMID 10611480. S2CID 27484018.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000278501, ENSG00000177370 GRCh38: Ensembl release 89: ENSG00000277649, ENSG00000278501, ENSG00000177370 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020843 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)".

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TIMM22

Contents

See also

Related Research Articles

References

Further reading