TIMM44

Last updated
TIMM44
Protein TIMM44 PDB 2cw9.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TIMM44 , TIM44, translocase of inner mitochondrial membrane 44
External IDs OMIM: 605058 MGI: 1343262 HomoloGene: 4631 GeneCards: TIMM44
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006351

NM_011592

RefSeq (protein)

NP_006342

NP_035722

Location (UCSC) Chr 19: 7.93 – 7.94 Mb Chr 8: 4.26 – 4.28 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial import inner membrane translocase subunit TIM44 is an enzyme that in humans is encoded by the TIMM44 gene. [5] [6] [7]

Contents


Interactions

TIMM44 has been shown to interact with ARAF. [5] [8]

See also

Related Research Articles

ARAF

Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme that in humans is encoded by the ARAF gene. A-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases.

YWHAB

14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene.

RRAS

Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.

TIMM8A

Mitochondrial import inner membrane translocase subunit Tim8 A, also known as Deafness-dystonia peptide or protein is an enzyme that in humans is encoded by the TIMM8A gene. This translocase has similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Deafness-dystonia syndrome and it is postulated that MTS/DFN-1 is a mitochondrial disease caused by a defective mitochondrial protein import system.

TOMM20

Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene.

IMMT

Mitochondrial inner membrane protein is a protein that in humans is encoded by the IMMT gene.

PRPF6

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.

TH1L

Negative elongation factor C/D is a protein that in humans is encoded by the TH1L gene.

TOMM22

Mitochondrial import receptor subunit TOM22 homolog is a protein that in humans is encoded by the TOMM22 gene.

TIMM13

Mitochondrial import inner membrane translocase subunit Tim13 is an enzyme that in humans is encoded by the TIMM13 gene.

TIMM10

Mitochondrial import inner membrane translocase subunit Tim10 is an enzyme that in humans is encoded by the TIMM10 gene.

TIMM10B

Mitochondrial import inner membrane translocase subunit Tim9 B is an enzyme that in humans is encoded by the FXC1 gene.

TIMM23

Mitochondrial import inner membrane translocase subunit Tim23 is an enzyme that in humans is encoded by the TIMM23 gene.

TIMM17A

Mitochondrial import inner membrane translocase subunit Tim17-A is an enzyme that in humans is encoded by the TIMM17A gene.

TOMM40

Translocase of outer mitochondrial membrane 40 homolog (yeast), also known as TOMM40, is a protein which in humans is encoded by the TOMM40 gene.

DNAJC19

Mitochondrial import inner membrane translocase subunit TIM14 is an enzyme that in humans is encoded by the DNAJC19 gene on chromosome 3. TIM14 belongs to the DnaJ family, which has been involved in Hsp40/Hsp70 chaperone systems. As a mitochondrial chaperone, TIM14 functions as part of the TIM23 complex import motor to facilitate the import of nuclear-encoded proteins into the mitochondria. TIM14 also complexes with prohibitin complexes to regulate mitochondrial morphogenesis, and has been implicated in dilated cardiomyopathy with ataxia.

TIMM9

Mitochondrial import inner membrane translocase subunit Tim9 is an enzyme that in humans is encoded by the TIMM9 gene.

TIMM22

Mitochondrial import inner membrane translocase subunit Tim22 is an enzyme that in humans is encoded by the TIMM22 gene.

TIMM50

Mitochondrial import inner membrane translocase subunit TIM50 is an protein that in humans is encoded by the TIMM50 gene. Tim50 is a subunit of the Tim23 translocase complex in the inner mitochondrial membrane. Mutations in TIMM50 can lead to epilepsy, severe intellectual disability, and 3-methylglutaconic aciduria. TIMM50 expression is increased in breast cancer cells and decreased in hypertrophic hearts.

PAM16

Mitochondrial import inner membrane translocase subunit TIM16 also known as presequence translocated-associated motor subunit PAM16, mitochondria-associated granulocyte macrophage CSF-signaling molecule, or presequence translocated-associated motor subunit PAM16 is a protein that in humans is encoded by the PAM16 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000104980 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002949 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (Jul 2000). "Isoform-Specific Localization of A-RAF in Mitochondria". Mol Cell Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC   85938 . PMID   10848612.
  6. Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz KD, Neupert W, Brunner M, Hofmann S (Jul 1999). "Genetic and structural characterization of the human mitochondrial inner membrane translocase". J Mol Biol. 289 (1): 69–82. doi:10.1006/jmbi.1999.2751. PMID   10339406.
  7. "Entrez Gene: TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)".
  8. Yuryev, Anton; Wennogle Lawrence P (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. United States. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN   0888-7543. PMID   12620389.

Further reading