TIMM44

TIMM44
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CW9
Identifiers
Aliases	TIMM44 , TIM44, translocase of inner mitochondrial membrane 44
External IDs	OMIM: 605058; MGI: 1343262; HomoloGene: 4631; GeneCards: TIMM44; OMA:TIMM44 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 7,926,718 bp [1] End 7,943,667 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 A1.1|8 1.99 cM Start 4,309,731 bp [2] End 4,325,913 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle right hemisphere of cerebellum muscle layer of sigmoid colon body of uterus left ventricle right ovary left ovary canal of the cervix gastric mucosa Top expressed in ciliary body retinal pigment epithelium right ventricle neural layer of retina sternocleidomastoid muscle digastric muscle temporal muscle brown adipose tissue internal carotid artery iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding chaperone binding protein binding ATP binding Cellular component mitochondrial inner membrane membrane mitochondrion mitochondrial matrix Biological process protein transport protein targeting to mitochondrion protein import into mitochondrial matrix Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10469 21856 Ensembl ENSG00000104980 ENSMUSG00000002949 UniProt O43615 O35857 RefSeq (mRNA) NM_006351 NM_011592 RefSeq (protein) NP_006342 NP_035722 Location (UCSC) Chr 19: 7.93 – 7.94 Mb Chr 8: 4.31 – 4.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial import inner membrane translocase subunit TIM44 is an enzyme that in humans is encoded by the TIMM44 gene. ^{[5] [6] [7]}

Interactions

TIMM44 has been shown to interact with ARAF. ^{[5] [8]}

See also

• Mitochondria Inner Membrane Translocase
• TIMM17A
• TIMM22
• TIMM23

References

1. GRCh38: Ensembl release 89: ENSG00000104980 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002949 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (Jul 2000). "Isoform-Specific Localization of A-RAF in Mitochondria". Mol Cell Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC   85938 . PMID   10848612.
6. Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz KD, Neupert W, Brunner M, Hofmann S (Jul 1999). "Genetic and structural characterization of the human mitochondrial inner membrane translocase". J Mol Biol. 289 (1): 69–82. doi:10.1006/jmbi.1999.2751. PMID   10339406.
7. "Entrez Gene: TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)".
8. Yuryev, Anton; Wennogle Lawrence P (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2). United States: 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN   0888-7543. PMID   12620389.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Moro F, Sirrenberg C, Schneider HC, et al. (1999). "The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix". EMBO J. 18 (13): 3667–75. doi:10.1093/emboj/18.13.3667. PMC   1171444 . PMID   10393182.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID   12620389.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Mitochondrial import inner membrane translocase subunit TIM44