TINAG

TINAG
Identifiers
Aliases	TINAG , TIN-AG, tubulointerstitial nephritis antigen
External IDs	OMIM: 606749 MGI: 1349477 HomoloGene: 8082 GeneCards: TINAG
Gene location (Human)
Chr.	Chromosome 6 (human)
End	54,390,142 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	76,953,076 bp
RNA expression pattern
	Top expressed in
	kidney; ; rectum; ; jejunal mucosa; ; duodenum; ; renal cortex; ; gallbladder; ; appendix; ; renal medulla; ; gastrocnemius muscle; ; muscle tissue;
	Top expressed in
	kidney; ; Paneth cell; ; left lung lobe; ; left colon; ; ileum; ; intestinal villus; ; jejunum; ; duodenum; ; right lung lobe; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	n/a
Gene ontology
Molecular function	scavenger receptor activity ; nucleotide binding ; cysteine-type endopeptidase activity ; polysaccharide binding ; cysteine-type peptidase activity ;
Cellular component	basement membrane ; extracellular region ; lysosome ; extracellular space ;
Biological process	cell adhesion ; proteolysis involved in cellular protein catabolic process ; receptor-mediated endocytosis ; immune response ; proteolysis ; vesicle-mediated transport ; endocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	27283
	26944
	ENSG00000137251
	ENSMUSG00000032357
	Q9UJW2
	n/a
	NM_014464
	NM_012033
	NP_055279
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Tubulointerstitial nephritis antigen is a protein that in humans is encoded by the TINAG gene.^[5]^[6]

TINAG is a basement membrane glycoprotein initially identified as a target of antibodies in some forms of immunologically mediated tubulointerstitial nephritis.[supplied by OMIM]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137251 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032357 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ikeda M, Takemura T, Hino S, Yoshioka K (Mar 2000). "Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen". Biochem Biophys Res Commun. 268 (1): 225–30. doi:10.1006/bbrc.2000.2103. PMID 10652240.
1 2 "Entrez Gene: TINAG tubulointerstitial nephritis antigen".

Katz A, Fish AJ, Santamaria P, et al. (1993). "Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy". Am. J. Med. 93 (6): 691–8. doi:10.1016/0002-9343(92)90205-P. PMID 1466368.
Butkowski RJ, Kleppel MM, Katz A, et al. (1992). "Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms". Kidney Int. 40 (5): 838–46. doi: 10.1038/ki.1991.283 . PMID 1762287.
Fliger FD, Wieslander J, Brentjens JR, et al. (1987). "Identification of a target antigen in human anti-tubular basement membrane nephritis". Kidney Int. 31 (3): 800–7. doi: 10.1038/ki.1987.69 . PMID 3553704.
Chen Y, Krishnamurti U, Wayner EA, et al. (1996). "REceptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen". Kidney Int. 49 (1): 153–7. doi: 10.1038/ki.1996.20 . PMID 8770961.
Nelson TR, Kim Y, Michael AF, et al. (1999). "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron". Connect. Tissue Res. 37 (1–2): 53–60. doi:10.3109/03008209809028899. PMID 9643646.
Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells". Nat. Genet. 23 (4): 405–12. doi:10.1038/70508. PMC 4940194 . PMID 10581025.
Zhou B, Nelson TR, Kashtan C, et al. (2000). "Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag)". J. Am. Soc. Nephrol. 11 (4): 658–68. doi: 10.1681/ASN.V114658 . PMID 10752525.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000137251 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032357 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10652240-5] Ikeda M, Takemura T, Hino S, Yoshioka K (Mar 2000). "Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen". Biochem Biophys Res Commun. 268 (1): 225–30. doi:10.1006/bbrc.2000.2103. PMID 10652240.

[entrez-6] 1 2 "Entrez Gene: TINAG tubulointerstitial nephritis antigen".

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TINAG

Related Research Articles

References

Further reading