TINAG

TINAG
Identifiers
Aliases	TINAG , TIN-AG, tubulointerstitial nephritis antigen
External IDs	OMIM: 606749; MGI: 1349477; HomoloGene: 8082; GeneCards: TINAG; OMA:TINAG - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p12.1 Start 54,307,859 bp [1] End 54,390,142 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 D Start 76,858,975 bp [2] End 76,953,076 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum human kidney rectum mucosa of transverse colon jejunal mucosa mucosa of sigmoid colon testicle duodenum renal cortex gallbladder Top expressed in human kidney right kidney Paneth cell left lung lobe efferent ductule left colon ileum intestinal villus jejunum duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function scavenger receptor activity nucleotide binding cysteine-type endopeptidase activity polysaccharide binding cysteine-type peptidase activity Cellular component basement membrane extracellular region lysosome extracellular space Biological process cell adhesion proteolysis involved in cellular protein catabolic process receptor-mediated endocytosis immune response proteolysis vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27283 26944 Ensembl ENSG00000137251 ENSMUSG00000032357 UniProt Q9UJW2 n/a RefSeq (mRNA) NM_014464 NM_012033 RefSeq (protein) NP_055279 n/a Location (UCSC) Chr 6: 54.31 – 54.39 Mb Chr 9: 76.86 – 76.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tubulointerstitial nephritis antigen is a protein that in humans is encoded by the TINAG gene. ^{[5] [6]}

TINAG is a basement membrane glycoprotein initially identified as a target of antibodies in some forms of immunologically mediated tubulointerstitial nephritis.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000137251 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032357 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ikeda M, Takemura T, Hino S, Yoshioka K (Mar 2000). "Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen". Biochem Biophys Res Commun. 268 (1): 225–30. doi:10.1006/bbrc.2000.2103. PMID   10652240.
6. "Entrez Gene: TINAG tubulointerstitial nephritis antigen".

Further reading

• Katz A, Fish AJ, Santamaria P, et al. (1993). "Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy". Am. J. Med. 93 (6): 691–8. doi:10.1016/0002-9343(92)90205-P. PMID   1466368.
• Butkowski RJ, Kleppel MM, Katz A, et al. (1992). "Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms". Kidney Int. 40 (5): 838–46. doi: 10.1038/ki.1991.283 . PMID   1762287.
• Fliger FD, Wieslander J, Brentjens JR, et al. (1987). "Identification of a target antigen in human anti-tubular basement membrane nephritis". Kidney Int. 31 (3): 800–7. doi: 10.1038/ki.1987.69 . PMID   3553704.
• Chen Y, Krishnamurti U, Wayner EA, et al. (1996). "REceptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen". Kidney Int. 49 (1): 153–7. doi: 10.1038/ki.1996.20 . PMID   8770961.
• Nelson TR, Kim Y, Michael AF, et al. (1999). "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron". Connect. Tissue Res. 37 (1–2): 53–60. doi:10.3109/03008209809028899. PMID   9643646.
• Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells". Nat. Genet. 23 (4): 405–12. doi:10.1038/70508. PMC   4940194 . PMID   10581025.
• Zhou B, Nelson TR, Kashtan C, et al. (2000). "Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag)". J. Am. Soc. Nephrol. 11 (4): 658–68. doi: 10.1681/ASN.V114658 . PMID   10752525.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.