| TJP3 | |||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||
| Aliases | TJP3 , ZO-3, ZO3, tight junction protein 3 | ||||||||||||||||||||||||
| External IDs | OMIM: 612689 MGI: 1351650 HomoloGene: 8458 GeneCards: TJP3 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 19: 3.71 – 3.75 Mb | Chr 10: 81.27 – 81.29 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||
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Tight junction protein ZO-3 is a protein that in humans is encoded by the TJP3 gene. [5]
TJP3 has been shown to interact with tight junction protein 1. [6]
Occludin is an enzyme that oxidizes NADH. It was first identified in epithelial cells as a 65 kDa integral plasma-membrane protein localized at the tight junctions, and together with Claudins, and zonula occludens-1 (ZO-1), has been considered a staple of tight junctions. Although it was originally shown to regulate the formation, maintenance, and function of tight junctions, its precise mechanism of action remained elusive, and most of its actions were initially attributed to conformational changes following its selective phosphorylation., and its redox-sensitive dimerization However, mounting evidence demonstrated that occludin is not only present in epithelial/endothelial cells, but is also found in large amounts in cells that do not have tight junctions but have very active metabolism: pericytes, neurons and astrocytes, oligodendrocytes, dendritic cells, monocytes/macrophages lymphocytes, and myocardium. Recent work, using molecular modeling, supported by biochemical and live-cell experiments in human cells demonstrated that occludin is a NADH oxidase that influences critical aspects of cell metabolism like glucose uptake, ATP production and gene expression. Furthermore, manipulation of occludin content in human cells is capable of influencing the expression of glucose transporters, and the activation of transcription factors like NFkB, and histones like sirtuins, which in a laboratory setting, proved capable of diminishing HIV replication rates in infected human macrophages.
PSD-95 also known as SAP-90 is a protein that in humans is encoded by the DLG4 gene.
Zonula occludens-1 ZO-1, also known as Tight junction protein-1 is a 220-kD peripheral membrane protein that is encoded by the TJP1 gene in humans. It belongs to the family of zona occludens proteins, which are tight junction-associated proteins and of which, ZO-1 is the first to be cloned. It was first isolated in 1986 by Stevenson and Goodenough using a monoclonal antibody raised in rodent liver to recognise a 225-kD polypeptide in whole liver homogenates and in tight junction-enriched membrane fractions. It has a role as a scaffold protein which cross-links and anchors Tight Junction (TJ) strand proteins, which are fibril-like structures within the lipid bilayer, to the actin cytoskeleton.
Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene.
Afadin is a protein that in humans is encoded by the AFDN gene.
Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. It belongs to the group of claudins.
Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene.
Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins.
Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.
Alpha-actinin 2 is a protein which in humans is encoded by the ACTN2 gene. This gene encodes an alpha-actinin isoform that is expressed in both skeletal and cardiac muscles and functions to anchor myofibrillar actin thin filaments and titin to Z-discs.
Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.
Junctional adhesion molecule A is a protein that in humans is encoded by the F11R gene. It has also been designated as CD321.
Zyxin is a protein that in humans is encoded by the ZYX gene.
Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. It is a member of the claudin protein family.
Claudin-2 is a protein that in humans is encoded by the CLDN2 gene. It belongs to the group of claudins.
InaD-like protein is a protein that in humans is encoded by the PATJ gene.
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the MAGI1 gene.
Cingulin is a cytosolic protein encoded by the CGN gene in humans localized at tight junctions (TJs) of vertebrate epithelial and endothelial cells.
αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. αE-catenin is highly expressed in cardiac muscle and localizes to adherens junctions at intercalated disc structures where it functions to mediate the anchorage of actin filaments to the sarcolemma. αE-catenin also plays a role in tumor metastasis and skin cell function.
Talin-1 is a protein that in humans is encoded by the TLN1 gene. Talin-1 is ubiquitously expressed, and is localized to costamere structures in cardiac and skeletal muscle cells, and to focal adhesions in smooth muscle and non-muscle cells. Talin-1 functions to mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. Altered expression of talin-1 has been observed in patients with heart failure, however no mutations in TLN1 have been linked with specific diseases.
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