TMED10

TMED10
Identifiers
Aliases	TMED10 , P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1, transmembrane p24 trafficking protein 10
External IDs	OMIM: 605406; MGI: 3782198; HomoloGene: 4972; GeneCards: TMED10; OMA:TMED10 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q24.3 Start 75,131,469 bp [1] End 75,176,612 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland islet of Langerhans stromal cell of endometrium germinal epithelium beta cell corpus epididymis caput epididymis olfactory zone of nasal mucosa mucosa of sigmoid colon skin of thigh n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding syntaxin binding protein-containing complex binding Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane secretory granule membrane membrane intracellular membrane-bounded organelle melanosome Golgi membrane cis-Golgi network plasma membrane transport vesicle membrane transport vesicle zymogen granule membrane endoplasmic reticulum ER to Golgi transport vesicle membrane trans-Golgi network transport vesicle endoplasmic reticulum-Golgi intermediate compartment membrane gamma-secretase complex cytoplasmic vesicle COPI-coated vesicle endoplasmic reticulum-Golgi intermediate compartment COPII-coated ER to Golgi transport vesicle Biological process regulation of amyloid-beta formation Golgi organization kidney development COPI coating of Golgi vesicle vesicle targeting, to, from or within Golgi COPI-coated vesicle budding endoplasmic reticulum to Golgi vesicle-mediated transport COPII vesicle coating response to alkaloid protein complex oligomerization vesicle cargo loading protein transport regulated exocytosis intracellular protein transport vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10972 100042773 Ensembl ENSG00000170348 ENSMUSG00000114251 UniProt P49755 n/a RefSeq (mRNA) NM_006827 XM_036158265 RefSeq (protein) NP_006818 n/a Location (UCSC) Chr 14: 75.13 – 75.18 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Transmembrane emp24 domain-containing protein 10 is a protein that in humans is encoded by the TMED10 gene. ^{[4] [5] [6]}

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000170348 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al. (Aug 1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–60. doi:10.1038/375754a0. PMID   7596406. S2CID   4308372.
5. Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (Sep 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". J Biol Chem. 271 (29): 17183–9. doi: 10.1074/jbc.271.29.17183 . PMID   8663407.
6. "Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Gommel D, Orci L, Emig EM, et al. (1999). "p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway". FEBS Lett. 447 (2–3): 179–85. doi: 10.1016/S0014-5793(99)00246-X . PMID   10214941.
• Hörer J, Blum R, Feick P, et al. (1999). "A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II". DNA Seq. 10 (2): 121–6. doi:10.3109/10425179909008429. PMID   10376215.
• Wang H, Kazanietz MG (2002). "Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain". J. Biol. Chem. 277 (6): 4541–50. doi: 10.1074/jbc.M107150200 . PMID   11689559.
• Majoul I, Straub M, Hell SW, et al. (2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Dev. Cell. 1 (1): 139–53. doi: 10.1016/S1534-5807(01)00004-1 . PMID   11703931.
• Gommel DU, Memon AR, Heiss A, et al. (2002). "Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23". EMBO J. 20 (23): 6751–60. doi:10.1093/emboj/20.23.6751. PMC   125325 . PMID   11726511.
• Barr FA, Preisinger C, Kopajtich R, Körner R (2002). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC   2150891 . PMID   11739402.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi: 10.1038/nature01348 . PMID   12508121.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi: 10.1074/jbc.M406644200 . PMID   15308636.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Chen F, Hasegawa H, Schmitt-Ulms G, et al. (2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature. 440 (7088): 1208–12. doi:10.1038/nature04667. PMID   16641999. S2CID   4349251.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID   17081065.