TMED10

TMED10
Identifiers
Aliases	TMED10 , P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1, transmembrane p24 trafficking protein 10
External IDs	OMIM: 605406 MGI: 3782198 HomoloGene: 4972 GeneCards: TMED10
Gene location (Human)
Chr.	Chromosome 14 (human)
End	75,176,612 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; islet of Langerhans; ; stromal cell of endometrium; ; germinal epithelium; ; corpus epididymis; ; caput epididymis; ; body of pancreas; ; seminal vesicula; ; gallbladder; ; parietal pleura;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; syntaxin binding ; protein-containing complex binding ;
Cellular component	integral component of membrane ; Golgi apparatus ; endoplasmic reticulum membrane ; secretory granule membrane ; membrane ; intracellular membrane-bounded organelle ; melanosome ; Golgi membrane ; cis-Golgi network ; plasma membrane ; transport vesicle membrane ; transport vesicle ; zymogen granule membrane ; endoplasmic reticulum ; ER to Golgi transport vesicle membrane ; trans-Golgi network transport vesicle ; endoplasmic reticulum-Golgi intermediate compartment membrane ; gamma-secretase complex ; cytoplasmic vesicle ; COPI-coated vesicle ; endoplasmic reticulum-Golgi intermediate compartment ; COPII-coated ER to Golgi transport vesicle ;
Biological process	regulation of amyloid-beta formation ; Golgi organization ; kidney development ; COPI coating of Golgi vesicle ; vesicle targeting, to, from or within Golgi ; COPI-coated vesicle budding ; endoplasmic reticulum to Golgi vesicle-mediated transport ; COPII vesicle coating ; response to alkaloid ; protein complex oligomerization ; vesicle cargo loading ; protein transport ; regulated exocytosis ; intracellular protein transport ; vesicle-mediated transport ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ;
	Sources:Amigo / QuickGO
Orthologs
	10972
	100042773
	ENSG00000170348
	ENSMUSG00000114251
	P49755
	n/a
	NM_006827
	XM_036158265
	NP_006818
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 28, 2023

Transmembrane emp24 domain-containing protein 10 is a protein that in humans is encoded by the TMED10 gene.^[4]^[5]^[6]

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.^[6]

Related Research Articles

P24 protein family is a group of transmembrane proteins that are major components of COPI and COPII-coated vesicles. The family is also known as EMP24/GP25L/p24 family and TMP21-like proteins. The latter naming was after transmembrane emp24 domain-containing protein 10 that was found in the human brain. It was claimed to block the beta-amyloid peptide, which is implicated in the pathogenesis of Alzheimer's disease.

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.

Coatomer subunit beta is a protein that in humans is encoded by the COPB1 gene.

Cux1 is a homeodomain protein that in humans is encoded by the CUX1 gene.

Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.

Coatomer subunit alpha is a protein that in humans is encoded by the COPA gene.

Chimerin 2 (beta-chimaerin) is a protein that in humans is encoded by the CHN2 gene.

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.

Coatomer subunit gamma is a protein that in humans is encoded by the COPG gene. It is one of seven proteins in the COPI coatomer complex that coats vesicles as they bud from the Golgi complex.

Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene.

Kinesin-associated protein 3 (KAP3) is a protein that in humans is encoded by the KIFAP3 gene. It is a non-motor, accessory subunit which co-oligomerizes with the motor subunits KIF3A and KIF3B or KIF3C, to form heterotrimeric kinesin-2 motor proteins. Kinesin-2 KAP subunits were initially characterized in echinoderms and mice.

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.

Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene.

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

Rh family, B glycoprotein, also known as RHBG, is an ammonia transporter protein which in humans is encoded by the RHBG gene.

Signal peptide peptidase-like 2A, also known as SPPL2A, is a human gene.

Transmembrane emp24 domain-containing protein 2 is a protein that in humans is encoded by the TMED2 gene.

Protein LMBR1L is a protein that in humans is encoded by the LMBR1L gene.

Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170348 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al. (Aug 1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–60. doi:10.1038/375754a0. PMID 7596406. S2CID 4308372.
↑ Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (Sep 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". J Biol Chem. 271 (29): 17183–9. doi: 10.1074/jbc.271.29.17183 . PMID 8663407.
1 2 "Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Gommel D, Orci L, Emig EM, et al. (1999). "p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway". FEBS Lett. 447 (2–3): 179–85. doi: 10.1016/S0014-5793(99)00246-X . PMID 10214941.
Hörer J, Blum R, Feick P, et al. (1999). "A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II". DNA Seq. 10 (2): 121–6. doi:10.3109/10425179909008429. PMID 10376215.
Wang H, Kazanietz MG (2002). "Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain". J. Biol. Chem. 277 (6): 4541–50. doi: 10.1074/jbc.M107150200 . PMID 11689559.
Majoul I, Straub M, Hell SW, et al. (2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Dev. Cell. 1 (1): 139–53. doi: 10.1016/S1534-5807(01)00004-1 . PMID 11703931.
Gommel DU, Memon AR, Heiss A, et al. (2002). "Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23". EMBO J. 20 (23): 6751–60. doi:10.1093/emboj/20.23.6751. PMC 125325 . PMID 11726511.
Barr FA, Preisinger C, Kopajtich R, Körner R (2002). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891 . PMID 11739402.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi: 10.1038/nature01348 . PMID 12508121.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi: 10.1074/jbc.M406644200 . PMID 15308636.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Chen F, Hasegawa H, Schmitt-Ulms G, et al. (2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature. 440 (7088): 1208–12. doi:10.1038/nature04667. PMID 16641999. S2CID 4349251.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170348 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7596406-4] Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al. (Aug 1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–60. doi:10.1038/375754a0. PMID 7596406. S2CID 4308372.

[pmid8663407-5] Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (Sep 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". J Biol Chem. 271 (29): 17183–9. doi: 10.1074/jbc.271.29.17183 . PMID 8663407.

[entrez-6] 1 2 "Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast)".

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TMED10

Related Research Articles

References

Further reading