TMEM219

TMEM219
Identifiers
Aliases	TMEM219 , IGFBP-3R, transmembrane protein 219
External IDs	MGI: 1915992; HomoloGene: 19263; GeneCards: TMEM219; OMA:TMEM219 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	29,973,050 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,522,089 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right uterine tube; ; C1 segment; ; mucosa of transverse colon; ; apex of heart; ; body of stomach; ; right adrenal cortex; ; mucosa of ileum; ; body of pancreas;
	Top expressed in
	lacrimal gland; ; granulocyte; ; ascending aorta; ; Paneth cell; ; right kidney; ; aortic valve; ; spermatocyte; ; proximal tubule; ; seminal vesicula; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	membrane ; integral component of membrane ; plasma membrane ;
Biological process	apoptotic process ; regulation of apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	124446
	68742
	ENSG00000149932
	ENSMUSG00000060538
	Q86XT9
	Q9D123
	NM_001083613 ; NM_194280
	NM_026827 ; NM_028389 ; NM_001374613
	NP_001077082 ; NP_919256 ; NP_001356617 ; NP_001356618 ; NP_001356619
	NP_081103 ; NP_082665 ; NP_001361542
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 28, 2025

Transmembrane protein 219 also known as insulin-like growth factor-binding protein 3 receptor or IGFBP-3R is a protein that in humans is encoded by the TMEM219 gene.^[5] IGFBP-3R acts as a cell death receptor for IGFBP3.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149932 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060538 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Transmembrane protein 219".
↑ Ingermann AR, Yang YF, Han J, Mikami A, Garza AE, Mohanraj L, Fan L, Idowu M, Ware JL, Kim HS, Lee DY, Oh Y (September 2010). "Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer". J. Biol. Chem. 285 (39): 30233–46. doi: 10.1074/jbc.M110.122226 . PMC 2943278 . PMID 20353938.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149932 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060538 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Transmembrane protein 219".

[6] Ingermann AR, Yang YF, Han J, Mikami A, Garza AE, Mohanraj L, Fan L, Idowu M, Ware JL, Kim HS, Lee DY, Oh Y (September 2010). "Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer". J. Biol. Chem. 285 (39): 30233–46. doi: 10.1074/jbc.M110.122226 . PMC 2943278 . PMID 20353938.

[1]

[2]

[3]

[4]

[5]

[6]