TNIK

TNIK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X7F, 5CWZ, 5AX9
Identifiers
Aliases	TNIK , TRAF2 and NCK interacting kinase, MRT54
External IDs	OMIM: 610005 MGI: 1916264 HomoloGene: 77943 GeneCards: TNIK
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q26.2-q26.31 Start 171,058,414 bp [1] End 171,460,408 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 A3 Start 28,317,363 bp [2] End 28,730,007 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte caudate nucleus jejunal mucosa secondary oocyte nucleus accumbens putamen corpus callosum internal globus pallidus duodenum Brodmann area 46 Top expressed in superior cervical ganglion trigeminal ganglion ventromedial nucleus temporal lobe mammillary body lateral hypothalamus superior frontal gyrus amygdala olfactory bulb facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding ATP binding MAP kinase kinase kinase kinase activity Cellular component cytoplasm recycling endosome endosome nucleoplasm apical plasma membrane extracellular exosome cytoskeleton nucleus cytosol presynapse glutamatergic synapse postsynaptic density, intracellular component Biological process actin cytoskeleton reorganization microvillus assembly positive regulation of protein phosphorylation intracellular signal transduction phosphorylation Wnt signaling pathway nervous system development regulation of dendrite morphogenesis protein phosphorylation cytoskeleton organization protein autophosphorylation protein localization to plasma membrane regulation of mitotic cell cycle regulation of apoptotic process MAPK cascade signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity neuron projection morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23043 665113 Ensembl ENSG00000154310 ENSMUSG00000027692 UniProt Q9UKE5 P83510 RefSeq (mRNA) NM_001161560 NM_001161561 NM_001161562 NM_001161563 NM_001161564 NM_001161565 NM_001161566 NM_015028 NM_001163007 NM_001163008 NM_001163009 NM_026910 RefSeq (protein) NP_001155032 NP_001155033 NP_001155034 NP_001155035 NP_001155036 NP_001155037 NP_001155038 NP_055843 NP_001156479 NP_001156480 NP_001156481 NP_081186 Location (UCSC) Chr 3: 171.06 – 171.46 Mb Chr 3: 28.32 – 28.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene. ^{[5] [6] [7]}

Function

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. ^{[6] [7]}

Interactions

TNIK has been shown to interact with KIAA0090, ^[8] although the significance is unclear. TNIK has been shown to phosphorylate Gelsolin, a protein involved in F-actin depolymerisation thus inducing cytoskeletal changes. ^[6]

TNIK plays an important role in pulmonary fibrosis. Inhibitors of TNIK are used in the treatment of pulmonary fibrosis. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000154310 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027692 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
6. Fu CA, Shen M, Huang BC, Lasaga J, Payan DG, Luo Y (Nov 1999). "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton". J Biol Chem. 274 (43): 30729–37. doi: 10.1074/jbc.274.43.30729 . PMID   10521462.
7. "Entrez Gene: TNIK TRAF2 and NCK interacting kinase".
8. Prieto C, De Las Rivas J (July 2006). "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Res. 34 (Web Server issue): W298–302. doi:10.1093/nar/gkl128. PMC   1538863 . PMID   16845013. Archived from the original on 2010-04-09.
9. Garneau-Tsodikova, Sylvie; Thannickal, Victor J. (2008). "Protein kinase inhibitors in the treatment of pulmonary fibrosis". Current Medicinal Chemistry. 15 (25): 2632–2640. doi:10.2174/092986708785908969. ISSN   0929-8673. PMID   18855683.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Yonekura H, Migita H, Sakurai S, et al. (1999). "Antisense display--a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes". Nucleic Acids Res. 27 (13): 2591–600. doi:10.1093/nar/27.13.2591. PMC   148466 . PMID   10373574.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Taira K, Umikawa M, Takei K, et al. (2005). "The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton". J. Biol. Chem. 279 (47): 49488–96. doi: 10.1074/jbc.M406370200 . PMID   15342639.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi: 10.1074/mcp.T600062-MCP200 . hdl: 10033/19756 . PMID   17192257.