Transportin-2 is a protein that in humans is encoded by the TNPO2 gene. [5] [6] [7]
Transportin-2 is a protein that in humans is encoded by the TNPO2 gene. [5] [6] [7]
TNPO2 has been shown to interact with NXF1, [6] NUP98 [8] and Ran (biology). [6]
A nuclear pore is a part of a large complex of proteins, known as a nuclear pore complex that spans the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are approximately 1,000 nuclear pore complexes (NPCs) in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in the life cycle. The human nuclear pore complex (hNPC) is a 110 megadalton (MDa) structure. The proteins that make up the nuclear pore complex are known as nucleoporins; each NPC contains at least 456 individual protein molecules and is composed of 34 distinct nucleoporin proteins. About half of the nucleoporins typically contain solenoid protein domains—either an alpha solenoid or a beta-propeller fold, or in some cases both as separate structural domains. The other half show structural characteristics typical of "natively unfolded" or intrinsically disordered proteins, i.e. they are highly flexible proteins that lack ordered tertiary structure. These disordered proteins are the FG nucleoporins, so called because their amino-acid sequence contains many phenylalanine—glycine repeats.
Importin is a type of karyopherin that transports protein molecules from the cell's cytoplasm to the nucleus. It does so by binding to specific recognition sequences, called nuclear localization sequences (NLS).
Ran also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.
Nucleoporin p62 (p62) is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues, followed by association with other complex proteins.
Nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex (NPC). The nuclear pore complex is a massive structure embedded in the nuclear envelope at sites where the inner and outer nuclear membranes fuse, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm. Nuclear pores enable the passive and facilitated transport of molecules across the nuclear envelope. Nucleoporins, a family of around 30 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nucleoporin 62 is the most abundant member of this family. Nucleoporins are able to transport molecules across the nuclear envelope at a very high rate. A single NPC is able to transport 60,000 protein molecules across the nuclear envelope every minute.
Importin subunit alpha-2 is a protein that in humans is encoded by the KPNA2 gene.
Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.
Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene.
Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.
Importin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene.
Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene.
karyopherin subunit alpha-4, also known as importin alpha-3, is a protein that in humans is encoded by the KPNA4 gene.
Importin-5 is a protein that in humans is encoded by the IPO5 gene. The protein encoded by this gene is a member of the importin beta family. Structurally, the protein adopts the shape of a right hand solenoid and is composed of 24 HEAT repeats.
60S ribosomal protein L5 is a protein that in humans is encoded by the RPL5 gene.
Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.
Transportin-1 is a protein that in humans is encoded by the TNPO1 gene.
Nucleoporin 214 (Nup2014) is a protein that in humans is encoded by the NUP214 gene.
Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.
Importin-7 is a protein that in humans is encoded by the IPO7 gene.
Transportin-3 is a protein that in humans is encoded by the TNPO3 gene.
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