TNRC6A

TNRC6A
Identifiers
Aliases	TNRC6A , CAGH26, GW1, GW182, TNRC6, trinucleotide repeat containing 6A, FAME6, trinucleotide repeat containing adaptor 6A
External IDs	OMIM: 610739 MGI: 2385292 HomoloGene: 41399 GeneCards: TNRC6A
Gene location (Human)
Chr.	Chromosome 16 (human)
End	24,827,632 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	122,794,519 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Achilles tendon; ; sural nerve; ; cerebellum; ; cerebellar hemisphere; ; pituitary gland; ; endometrium; ; gastric mucosa; ; anterior pituitary; ; Right adrenal gland;
	Top expressed in
	ciliary body; ; retinal pigment epithelium; ; iris; ; primitive streak; ; arcuate nucleus; ; median eminence; ; lacrimal gland; ; ventromedial nucleus; ; parotid gland; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; nucleic acid binding ; RNA binding ;
Cellular component	cytoplasm ; cytosol ; Golgi apparatus ; intracellular membrane-bounded organelle ; P-body ; nucleoplasm ;
Biological process	RNA interference ; gene silencing by miRNA ; regulation of translation ; miRNA-mediated gene silencing by inhibition of translation ; Wnt signaling pathway, calcium modulating pathway ; gene silencing ; regulation of gene silencing by miRNA ; regulation of megakaryocyte differentiation ; cellular response to starvation ; positive regulation of gene expression ; negative regulation of gene expression ; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ;
	Sources:Amigo / QuickGO
Orthologs
	27327
	233833
	ENSG00000090905 ; ENSG00000288130
	ENSMUSG00000052707
	Q8NDV7
	Q3UHK8
	NM_014494 ; NM_001330520 ; NM_001351850
	NM_144925
	NP_001317449 ; NP_055309 ; NP_001338779
	NP_659174
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Trinucleotide repeat-containing gene 6A protein is a protein that in humans is encoded by the TNRC6A gene.^[5]^[6]

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.^[6]

Related Research Articles

P-bodies, or processing bodies are distinct foci formed by phase separation within the cytoplasm of the eukaryotic cell consisting of many enzymes involved in mRNA turnover. P-bodies are highly conserved structures and have been observed in somatic cells originating from vertebrates and invertebrates, plants and yeast. To date, P-bodies have been demonstrated to play fundamental roles in general mRNA decay, nonsense-mediated mRNA decay, adenylate-uridylate-rich element mediated mRNA decay, and microRNA (miRNA) induced mRNA silencing. Not all mRNAs which enter P-bodies are degraded, as it has been demonstrated that some mRNAs can exit P-bodies and re-initiate translation. Purification and sequencing of the mRNA from purified processing bodies showed that these mRNAs are largely translationally repressed upstream of translation initiation and are protected from 5' mRNA decay.

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.

Protein argonaute-2 is a protein that in humans is encoded by the EIF2C2 gene.

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Heterogeneous nuclear ribonucleoprotein L is a protein that in humans is encoded by the HNRNPL gene.

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.

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Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene.

Cytoplasmic dynein 1 intermediate chain 2 is a protein that in humans is encoded by the DYNC1I2 gene.

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 1 is an enzyme that in humans is encoded by the RPN1 gene.

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mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.

60S ribosomal protein L35 is a protein that in humans is encoded by the RPL35 gene.

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.

60S ribosomal protein L18 is a protein that in humans is encoded by the RPL18 gene.

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.

Cytoplasmic polyadenylation element-binding protein 1 is a protein that in humans is encoded by the CPEB1 gene.

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Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.

References

1 2 3 ENSG00000288130 GRCh38: Ensembl release 89: ENSG00000090905, ENSG00000288130 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052707 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.
1 2 "Entrez Gene: TNRC6A trinucleotide repeat containing 6A".

Yamagata K, Takeda J, Menzel S, et al. (1996). "Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle". Diabetologia. 39 (6): 725–730. doi:10.1007/BF00418545. PMID 8781769. S2CID 41411039.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–150. doi: 10.1093/dnares/7.2.143 . PMID 10819331.
Eystathioy T, Chan EK, Tenenbaum SA, et al. (2002). "A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles". Mol. Biol. Cell. 13 (4): 1338–1351. doi:10.1091/mbc.01-11-0544. PMC 102273 . PMID 11950943.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Eystathioy T, Chan EK, Mahler M, et al. (2004). "A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182". Hybrid. Hybridomics. 22 (2): 79–86. doi:10.1089/153685903321947996. PMID 12831532.
Eystathioy T, Jakymiw A, Chan EK, et al. (2003). "The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies". RNA. 9 (10): 1171–1173. doi:10.1261/rna.5810203. PMC 1370480 . PMID 13130130.
Eystathioy T, Chan EK, Takeuchi K, et al. (2004). "Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182". J. Mol. Med. 81 (12): 811–818. doi:10.1007/s00109-003-0495-y. PMID 14598044. S2CID 31604559.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Yang Z, Jakymiw A, Wood MR, et al. (2005). "GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation". J. Cell Sci. 117 (Pt 23): 5567–5578. doi: 10.1242/jcs.01477 . PMID 15494374.
Sen GL, Blau HM (2005). "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies". Nat. Cell Biol. 7 (6): 633–636. doi:10.1038/ncb1265. PMID 15908945. S2CID 6085169.
Rehwinkel J, Behm-Ansmant I, Gatfield D, Izaurralde E (2005). "A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing". RNA. 11 (11): 1640–1647. doi:10.1261/rna.2191905. PMC 1370850 . PMID 16177138.
Jakymiw A, Lian S, Eystathioy T, et al. (2006). "Disruption of GW bodies impairs mammalian RNA interference". Nat. Cell Biol. 7 (12): 1167–1174. doi:10.1038/ncb1334. PMID 16284622. S2CID 36630239.
Liu J, Rivas FV, Wohlschlegel J, et al. (2006). "A role for the P-body component GW182 in microRNA function". Nat. Cell Biol. 7 (12): 1161–1166. doi:10.1038/ncb1333. PMC 1804202 . PMID 16284623.
Lian S, Jakymiw A, Eystathioy T, et al. (2007). "GW bodies, microRNAs and the cell cycle". Cell Cycle. 5 (3): 242–245. doi: 10.4161/cc.5.3.2410 . PMID 16418578.
Behm-Ansmant I, Rehwinkel J, Doerks T, et al. (2006). "mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes". Genes Dev. 20 (14): 1885–1898. doi:10.1101/gad.1424106. PMC 1522082 . PMID 16815998.
Schneider MD, Najand N, Chaker S, et al. (2006). "Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development". J. Cell Biol. 174 (3): 349–358. doi:10.1083/jcb.200512103. PMC 2064231 . PMID 16880270.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000288130 GRCh38: Ensembl release 89: ENSG00000090905, ENSG00000288130 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052707 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9225980-5] Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.

[entrez-6] 1 2 "Entrez Gene: TNRC6A trinucleotide repeat containing 6A".

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TNRC6A

Related Research Articles

References

Further reading