TNRC6B

TNRC6B
Identifiers
Aliases	TNRC6B , trinucleotide repeat containing 6B, trinucleotide repeat containing adaptor 6B, GDSBA
External IDs	OMIM: 610740; MGI: 2443730; HomoloGene: 66194; GeneCards: TNRC6B; OMA:TNRC6B - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 40,044,817 bp [1] End 40,335,808 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 80,595,514 bp [2] End 80,825,286 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell epithelium of nasopharynx sural nerve oocyte caput epididymis trabecular bone secondary oocyte seminal vesicula nipple tail of epididymis Top expressed in zygote secondary oocyte granulocyte genital tubercle tibiofemoral joint tail of embryo neural layer of retina human fetus lens inferior colliculi More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding Cellular component cytoplasm cytosol P-body nucleoplasm Biological process RNA interference positive regulation of nuclear-transcribed mRNA poly(A) tail shortening regulation of translation positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay gene silencing miRNA-mediated gene silencing by inhibition of translation Wnt signaling pathway, calcium modulating pathway regulation of megakaryocyte differentiation positive regulation of gene expression negative regulation of gene expression gene silencing by miRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23112 213988 Ensembl ENSG00000100354 ENSMUSG00000047888 UniProt Q9UPQ9 Q8BKI2 RefSeq (mRNA) NM_015088 NM_001024843 NM_001162501 NM_144812 NM_177124 RefSeq (protein) NP_001020014 NP_001155973 NP_055903 NP_659061 NP_796098 Location (UCSC) Chr 22: 40.04 – 40.34 Mb Chr 15: 80.6 – 80.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene. ^[5]

Interactions

TNRC6B has been shown to interact with EIF2C2. ^[6] It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa cells. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000100354 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047888 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TNRC6B trinucleotide repeat containing 6B".
6. Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID   17891150. S2CID   8136380.
7. Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R, Tuschl T (December 2005). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. hdl: 11858/00-001M-0000-0012-E763-B . PMID   16289642. S2CID   2740901.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID   10409428.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID   10470851.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Schneider MD, Najand N, Chaker S, et al. (2006). "Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development". J. Cell Biol. 174 (3): 349–58. doi:10.1083/jcb.200512103. PMC   2064231 . PMID   16880270.