TOMM20

TOMM20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4APO
Identifiers
Aliases	TOMM20 , MAS20, MOM19, TOM20, translocase of outer mitochondrial membrane 20
External IDs	OMIM: 601848; MGI: 1915202; HomoloGene: 44649; GeneCards: TOMM20; OMA:TOMM20 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q42.3 Start 235,109,341 bp [1] End 235,128,837 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E2 Start 127,657,417 bp [2] End 127,672,594 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland skin of thigh Brodmann area 10 frontal pole skin of hip middle frontal gyrus caput epididymis lateral nuclear group of thalamus corpus epididymis pons Top expressed in yolk sac embryo embryo olfactory tubercle nucleus accumbens superior frontal gyrus subiculum ventromedial nucleus temporal lobe dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-transporting ATPase activity protein binding mitochondrion targeting sequence binding unfolded protein binding protein transmembrane transporter activity Cellular component integral component of membrane mitochondria associated membranes membrane mitochondrial outer membrane translocase complex integral component of mitochondrial outer membrane mitochondrial outer membrane mitochondrion mitochondrial envelope Biological process protein targeting tRNA import into mitochondrion mitochondrial outer membrane translocase complex assembly protein import into mitochondrial matrix protein transport intracellular protein transport protein targeting to mitochondrion protein deubiquitination response to muscle activity response to 3,3',5-triiodo-L-thyronine macroautophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9804 67952 Ensembl ENSG00000173726 ENSMUSG00000093904 UniProt Q15388 Q9DCC8 RefSeq (mRNA) NM_014765 NM_024214 RefSeq (protein) NP_055580 NP_055580.1 NP_077176 Location (UCSC) Chr 1: 235.11 – 235.13 Mb Chr 8: 127.66 – 127.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene. ^{[5] [6] [7] [8]} TOM20 is one of the receptor systems of the translocase of the outer membrane (TOM) complex in the outer mitochondrial membrane.

Function

In mitochondrial protein import, TOM20 is closely associated with the pore-forming TOM40 complex and acts by recognizing and binding the N-terminal MTSs (matrix-targeting sequences), which form an amphipathic alpha helix and aid passage of the target proteins into the mitochondrial matrix. ^[9]

See also

• TOMM22
• TOMM40
• TOMM70A

References

1. GRCh38: Ensembl release 89: ENSG00000173726 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000093904 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seki N, Moczko M, Nagase T, Zufall N, Ehmann B, Dietmeier K, et al. (November 1995). "A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex". FEBS Letters. 375 (3): 307–310. doi:10.1016/0014-5793(95)01229-8. PMID   7498524. S2CID   45148104.
6. Goping IS, Millar DG, Shore GC (October 1995). "Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast". FEBS Letters. 373 (1): 45–50. doi:10.1016/0014-5793(95)01010-C. PMID   7589431. S2CID   1204415.
7. Likić VA, Perry A, Hulett J, Derby M, Traven A, Waller RF, et al. (March 2005). "Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20". Journal of Molecular Biology. 347 (1): 81–93. doi:10.1016/j.jmb.2004.12.057. PMID   15733919.
8. "Entrez Gene: TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)".
9. Hansen KG, Herrmann JM (June 2019). "Transport of Proteins into Mitochondria". The Protein Journal. 38 (3): 330–342. doi:10.1007/s10930-019-09819-6. PMID   30868341. S2CID   76662487.

Further reading

• Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Research. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
• Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Research. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID   7584028.
• Schleiff E, Shore GC, Goping IS (March 1997). "Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20-glutathione S-transferase and mitochondrial precursor proteins". FEBS Letters. 404 (2–3): 314–318. doi: 10.1016/S0014-5793(97)00145-2 . PMID   9119086. S2CID   29177508.
• Schleiff E, Shore GC, Goping IS (July 1997). "Interactions of the human mitochondrial protein import receptor, hTom20, with precursor proteins in vitro reveal pleiotropic specificities and different receptor domain requirements". The Journal of Biological Chemistry. 272 (28): 17784–17789. doi: 10.1074/jbc.272.28.17784 . PMID   9211931.
• Schleiff E, Turnbull JL (September 1998). "Characterization of the N-terminal targeting signal binding domain of the mitochondrial outer membrane receptor, Tom20". Biochemistry. 37 (38): 13052–13058. doi:10.1021/bi980746y. PMID   9748310.
• Yano M, Kanazawa M, Terada K, Takeya M, Hoogenraad N, Mori M (October 1998). "Functional analysis of human mitochondrial receptor Tom20 for protein import into mitochondria". The Journal of Biological Chemistry. 273 (41): 26844–26851. doi: 10.1074/jbc.273.41.26844 . PMID   9756929.
• Hernández JM, Giner P, Hernández-Yago J (November 1999). "Gene structure of the human mitochondrial outer membrane receptor Tom20 and evolutionary study of its family of processed pseudogenes". Gene. 239 (2): 283–291. doi:10.1016/S0378-1119(99)00409-6. PMID   10548729.
• Suzuki H, Okazawa Y, Komiya T, Saeki K, Mekada E, Kitada S, et al. (December 2000). "Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane". The Journal of Biological Chemistry. 275 (48): 37930–37936. doi: 10.1074/jbc.M006558200 . PMID   10980201.
• Yano M, Hoogenraad N, Terada K, Mori M (October 2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria". Molecular and Cellular Biology. 20 (19): 7205–7213. doi:10.1128/MCB.20.19.7205-7213.2000. PMC   86274 . PMID   10982837.
• Abdul KM, Terada K, Yano M, Ryan MT, Streimann I, Hoogenraad NJ, Mori M (October 2000). "Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex". Biochemical and Biophysical Research Communications. 276 (3): 1028–1034. CiteSeerX   10.1.1.379.8183 . doi:10.1006/bbrc.2000.3589. PMID   11027586.
• Mukhopadhyay A, Avramova LV, Weiner H (April 2002). "Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins". Archives of Biochemistry and Biophysics. 400 (1): 97–104. doi:10.1006/abbi.2002.2777. PMID   11913975.
• Yano M, Terada K, Mori M (October 2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins". The Journal of Cell Biology. 163 (1): 45–56. doi:10.1083/jcb.200305051. PMC   2173431 . PMID   14557246.
• Yano M, Terada K, Mori M (March 2004). "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity". The Journal of Biological Chemistry. 279 (11): 10808–10813. doi: 10.1074/jbc.M311710200 . PMID   14699115.
• Humphries AD, Streimann IC, Stojanovski D, Johnston AJ, Yano M, Hoogenraad NJ, Ryan MT (March 2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". The Journal of Biological Chemistry. 280 (12): 11535–11543. doi: 10.1074/jbc.M413816200 . PMID   15644312.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.