TRA2A

TRA2A
Identifiers
Aliases	TRA2A , AWMS1, HSU53209, transformer 2 alpha homolog
External IDs	OMIM: 602718 MGI: 1933972 HomoloGene: 40866 GeneCards: TRA2A
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p15.3 Start 23,504,780 bp [1] End 23,532,041 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.3 Start 49,220,858 bp [2] End 49,240,967 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ganglionic eminence canal of the cervix sural nerve right lobe of thyroid gland vagina skin of abdomen left uterine tube minor salivary gland left lobe of thyroid gland Top expressed in pineal gland abdominal wall maxillary prominence dermis superior cervical ganglion ganglionic eminence conjunctival fornix cumulus cell trigeminal ganglion medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding RNA binding Cellular component nucleolus intracellular membrane-bounded organelle nucleus ribonucleoprotein complex Biological process mRNA splicing, via spliceosome mRNA processing RNA splicing positive regulation of mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29896 101214 Ensembl ENSG00000164548 ENSMUSG00000029817 UniProt Q13595 Q6PFR5 RefSeq (mRNA) NM_001282757 NM_001282758 NM_001282759 NM_013293 NM_001362759 NM_001362760 NM_001362761 NM_198102 NM_001347209 NM_001362188 RefSeq (protein) NP_001269686 NP_001269687 NP_001269688 NP_037425 NP_001349688 NP_001349689 NP_001349690 n/a Location (UCSC) Chr 7: 23.5 – 23.53 Mb Chr 6: 49.22 – 49.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene. ^{[5] [6] [7]}

This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000164548 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029817 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dauwalder B, Amaya-Manzanares F, Mattox W (Oct 1996). "A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions". Proc Natl Acad Sci U S A. 93 (17): 9004–9. doi: 10.1073/pnas.93.17.9004 . PMC   38585 . PMID   8799144.
6. Tacke R, Tohyama M, Ogawa S, Manley JL (May 1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. doi: 10.1016/S0092-8674(00)81153-8 . PMID   9546399. S2CID   15384749.
7. "Entrez Gene: TRA2A transformer-2 alpha".

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi: 10.1038/sj.onc.1206406 . PMID   12761501.
• Shin C, Feng Y, Manley JL (2004). "Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock". Nature. 427 (6974): 553–8. doi:10.1038/nature02288. PMID   14765198. S2CID   4423246.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID   16097034. S2CID   895879.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.