TRA2B

TRA2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQC, 2KXN, 2RRA, 2RRB
Identifiers
Aliases	TRA2B , Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B, transformer 2 beta homolog (Drosophila), transformer 2 beta homolog
External IDs	OMIM: 602719; MGI: 106016; HomoloGene: 20965; GeneCards: TRA2B; OMA:TRA2B - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q27.2 Start 185,914,558 bp [1] End 185,938,103 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 B1|16 13.18 cM Start 22,063,299 bp [2] End 22,084,755 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura ventricular zone embryo visceral pleura endothelial cell ganglionic eminence amniotic fluid tibia epithelium of nasopharynx Top expressed in tail of embryo genital tubercle ventricular zone yolk sac embryo embryo spermatocyte neural layer of retina morula blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding mRNA binding protein binding poly-purine tract binding RNA binding protein domain specific binding pre-mRNA binding identical protein binding Cellular component nucleus nuclear inner membrane nucleoplasm spliceosomal complex ribonucleoprotein complex Biological process RNA splicing, via transesterification reactions RNA splicing cerebral cortex regionalization mRNA processing negative regulation of mRNA splicing, via spliceosome embryonic brain development mRNA splicing, via spliceosome positive regulation of mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome regulation of RNA splicing protein complex oligomerization cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6434 20462 Ensembl ENSG00000136527 ENSMUSG00000022858 UniProt P62995 P62996 RefSeq (mRNA) NM_001243879 NM_004593 NM_009186 NM_001330554 NM_001330555 RefSeq (protein) NP_001230808 NP_004584 NP_001317483 NP_001317484 NP_033212 Location (UCSC) Chr 3: 185.91 – 185.94 Mb Chr 16: 22.06 – 22.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10), is a protein that in humans is encoded by the TRA2B gene. ^{[5] [6]}

TRA2B contains a poison exon whose inclusion is autoregulated by TRA2B protein. Proper regulation of poison exon inclusion in TRA2B is important for T cell fate. ^[7]

Interactions

TRA2B has been shown to interact with RBMX. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000136527 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022858 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SFRS10 splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)".
6. Nayler O, Cap C, Stamm S (October 1998). "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform". Genomics. 53 (2): 191–202. doi:10.1006/geno.1998.5471. PMID   9790768.
7. Karginov, Timofey A.; Ménoret, Antoine; Leclair, Nathan K.; Harrison, Andrew G.; Chandiran, Karthik; Suarez-Ramirez, Jenny E.; Yurieva, Marina; Karlinsey, Keaton; Wang, Penghua; O’Neill, Rachel J.; Murphy, Patrick A.; Adler, Adam J.; Cauley, Linda S.; Anczuków, Olga; Zhou, Beiyan (2024-09-13). "Autoregulated splicing of TRA2 β programs T cell fate in response to antigen-receptor stimulation". Science. 385 (6714). doi:10.1126/science.adj1979. ISSN   0036-8075. PMC   11697694 .
8. Hofmann, Yvonne; Wirth Brunhilde (Aug 2002). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. 11 (17): 2037–49. doi: 10.1093/hmg/11.17.2037 . ISSN   0964-6906. PMID   12165565.

Further reading

• Matsuo N, Ogawa S, Imai Y, et al. (1996). "Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation". J. Biol. Chem. 270 (47): 28216–22. doi: 10.1074/jbc.270.47.28216 . PMID   7499316.
• Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics. 33 (1): 151–2. doi: 10.1006/geno.1996.0177 . PMID   8617505.
• Beil B, Screaton G, Stamm S (1997). "Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing". DNA Cell Biol. 16 (6): 679–90. doi:10.1089/dna.1997.16.679. PMID   9212162.
• Imai Y, Matsuo N, Ogawa S, et al. (1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation". Brain Res. Mol. Brain Res. 53 (1–2): 33–40. doi:10.1016/S0169-328X(97)00262-3. PMID   9473574.
• Tacke R, Tohyama M, Ogawa S, Manley JL (1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. doi: 10.1016/S0092-8674(00)81153-8 . PMID   9546399. S2CID   15384749.
• Nayler O, Cap C, Stamm S (1998). "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform". Genomics. 53 (2): 191–202. doi:10.1006/geno.1998.5471. PMID   9790768.
• Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. Bibcode:1999PNAS...96.6125E. doi: 10.1073/pnas.96.11.6125 . PMC   26846 . PMID   10339552.
• Lai MC, Lin RI, Huang SY, et al. (2000). "A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins". J. Biol. Chem. 275 (11): 7950–7. doi: 10.1074/jbc.275.11.7950 . PMID   10713112.
• Venables JP, Elliott DJ, Makarova OV, et al. (2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Hum. Mol. Genet. 9 (5): 685–94. doi: 10.1093/hmg/9.5.685 . PMID   10749975.
• Helmken C, Wirth B (2001). "Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy". Hum. Genet. 107 (6): 554–8. doi:10.1007/s004390000409. PMID   11153908. S2CID   30528707.
• Young PJ, DiDonato CJ, Hu D, et al. (2002). "SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1". Hum. Mol. Genet. 11 (5): 577–87. doi: 10.1093/hmg/11.5.577 . PMID   11875052.
• Hofmann Y, Wirth B (2003). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. 11 (17): 2037–49. doi: 10.1093/hmg/11.17.2037 . PMID   12165565.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tran Q, Coleman TP, Roesser JR (2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer". Biochim. Biophys. Acta. 1625 (2): 141–52. doi:10.1016/S0167-4781(02)00600-0. PMID   12531473.
• El Yazidi-Belkoura I, Adriaenssens E, Dollé L, et al. (2003). "Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells". J. Biol. Chem. 278 (19): 16952–6. doi: 10.1074/jbc.M300631200 . PMID   12604596.
• Jiang Z, Tang H, Havlioglu N, et al. (2003). "Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta". J. Biol. Chem. 278 (21): 18997–9007. doi: 10.1074/jbc.M301800200 . PMC   2140226 . PMID   12649279.
• Chen X, Guo L, Lin W, Xu P (2004). "Expression of Tra2beta isoforms is developmentally regulated in a tissue- and temporal-specific pattern". Cell Biol. Int. 27 (6): 491–6. doi:10.1016/S1065-6995(03)00072-6. PMID   12798777. S2CID   44758770.
• Helmken C, Hofmann Y, Schoenen F, et al. (2004). "Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1". Hum. Genet. 114 (1): 11–21. doi:10.1007/s00439-003-1025-2. PMID   14520560. S2CID   19872246.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC   207616 . PMID   14559993.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.