TRIL (gene)

TRIL
Identifiers
Aliases	TRIL , KIAA0644, TLR4 interactor with leucine rich repeats
External IDs	OMIM: 613356 MGI: 1914123 HomoloGene: 69404 GeneCards: TRIL
Gene location (Human)
Chr.	Chromosome 7 (human)
End	28,958,330 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	53,797,815 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; external globus pallidus; ; caudate nucleus; ; putamen; ; Region I of hippocampus proper; ; amygdala; ; nucleus accumbens; ; ventral tegmental area; ; inferior olivary nucleus; ; hypothalamus;
	Top expressed in
	utricle; ; vas deferens; ; renal corpuscle; ; medullary collecting duct; ; maxillary prominence; ; substantia nigra; ; external carotid artery; ; dorsal tegmental nucleus; ; suprachiasmatic nucleus; ; internal carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipopolysaccharide binding ;
Cellular component	integral component of membrane ; lipopolysaccharide receptor complex ; membrane ; extracellular space ; extracellular matrix ;
Biological process	regulation of cytokine production involved in immune response ; innate immune response ; inflammatory response ; toll-like receptor 4 signaling pathway ; immune system process ;
	Sources:Amigo / QuickGO
Orthologs
	9865
	66873
	ENSG00000255690
	ENSMUSG00000043496
	Q7L0X0
	Q9DBY4
	NM_014817
	NM_025817
	NP_055632
	NP_080093
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 02, 2024

KIAA0644, also known as TRIL or TLR4 interactor with leucine rich repeats, is a protein that in humans is encoded by the KIAA0644 gene.^[5]

Function

The exact function of KIAA0644 is not known. It is, however, a member of the leucine-rich repeat family of proteins, which are known to be involved in protein-protein interactions. This protein is known to interact with the TLR4 protein.

TRIL is a component of the TLR4 complex and is induced in a number of cell types by lipopolysaccharide (LPS).^[6]

Protein sequence

The main isoform of the human protein is 811 amino long and is composed primarily of leucine (17%), alanine and arginine (~10%), and glycine (~ 8.5%) residues. The protein sequence is predicted to consists mostly of α-helices and a few β-sheet

Homology

KIAA0644 is conserved well among mammals but can be found in all chordates with lower sequence identities.

Gene neighborhood

The KIAA0644 gene is neighbors to mRNA-cAMP responsive element binding gene downstream and mRNA carboxypeptidase and serine carboxypeptidase gene upstream ^[7]^[8]

Related Research Articles

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Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000255690 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043496 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TRIL TLR4 interactor with leucine rich repeats" . Retrieved 13 May 2010.
↑ Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA (September 2009). "TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain". J. Immunol. 183 (6): 3989–3995. doi: 10.4049/jimmunol.0901518 . PMID 19710467.
↑ "NCBI Entrez" . Retrieved 13 May 2010.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" (PDF). DNA Res. 5 (3): 169–176. doi: 10.1093/dnares/5.3.169 . PMID 9734811.