TRIP4

TRIP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5O
Identifiers
Aliases	TRIP4 , ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4, MDCDC
External IDs	OMIM: 604501; MGI: 1928469; HomoloGene: 9426; GeneCards: TRIP4; OMA:TRIP4 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q22.31 Start 64,387,748 bp [1] End 64,455,303 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 C Start 65,736,212 bp [2] End 65,816,076 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve amniotic fluid mucosa of transverse colon jejunal mucosa monocyte gonad right lobe of thyroid gland left lobe of thyroid gland ganglionic eminence anterior pituitary Top expressed in pineal gland granulocyte spermatocyte left lobe of liver zygote spermatid lumbar spinal ganglion secondary oocyte substantia nigra cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protease binding transcription coactivator activity zinc ion binding estrogen receptor binding protein binding histone acetyltransferase binding nuclear receptor binding ubiquitin-like protein ligase binding metal ion binding protein kinase binding Cellular component cytoplasm cytosol cytoskeleton nucleus nucleoplasm microtubule organizing center neuromuscular junction nuclear body activating signal cointegrator 1 complex centrosome protein-containing complex Biological process positive regulation of transcription, DNA-templated toxin transport intracellular estrogen receptor signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated regulation of myoblast differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9325 56404 Ensembl ENSG00000103671 ENSMUSG00000032386 UniProt Q15650 Q9QXN3 RefSeq (mRNA) NM_016213 NM_001321924 NM_001170907 NM_019797 NM_001357872 RefSeq (protein) NP_001308853 NP_057297 NP_001164378 NP_062771 NP_001344801 Location (UCSC) Chr 15: 64.39 – 64.46 Mb Chr 9: 65.74 – 65.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Activating signal cointegrator 1 is a protein in humans that is encoded by the TRIP4 gene. ^{[5] [6]}

Interactions

TRIP4 has been shown to interact with Nuclear receptor coactivator 1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000103671 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032386 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi: 10.1210/mend.9.2.7776974 . PMID   7776974.
6. "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".
7. Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC   84603 . PMID   10454579.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jung DJ, Sung HS, Goo YW, et al. (2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC   139772 . PMID   12077347.
• Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi: 10.1074/jbc.274.48.34283 . PMID   10567404.
• Kim HJ, Yi JY, Sung HS, et al. (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC   84603 . PMID   10454579.