TTF2

TTF2
Identifiers
Aliases	TTF2 , HuF2, ZGRF6, transcription termination factor, RNA polymerase II, transcription termination factor 2, F2
External IDs	OMIM: 604718 MGI: 1921294 HomoloGene: 37826 GeneCards: TTF2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	117,107,453 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	100,969,663 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; bone marrow; ; corpus callosum; ; kidney; ; Achilles tendon; ; thymus; ; lung; ; appendix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; nucleotide binding ; ATP-dependent activity, acting on DNA ; zinc ion binding ; GO:0001948 protein binding ; ATP binding ; GO:0008026 helicase activity ; hydrolase activity ;
Cellular component	spliceosomal complex ; transcription elongation factor complex ; nucleus ; cytoplasm ; cytosol ;
Biological process	DNA-templated transcription, termination ; termination of RNA polymerase II transcription ; mRNA processing ; regulation of transcription, DNA-templated ; RNA splicing ; transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	8458
	74044
	ENSG00000116830
	ENSMUSG00000033222
	Q9UNY4
	Q5NC05
	NM_003594
	NM_001013026
	NP_003585
	NP_001013044
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 09, 2022

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.^[5]^[6]

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.^[6]

Interactions

TTF2 has been shown to interact with CDC5L.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116830 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033222 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liu M, Xie Z, Price DH (October 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member". The Journal of Biological Chemistry. 273 (40): 25541–4. doi: 10.1074/jbc.273.40.25541 . PMID 9748214.
1 2 "Entrez Gene: TTF2 transcription termination factor, RNA polymerase II".
↑ Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359 . doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.

Girdham CH, Glover DM (October 1991). "Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein". Genes & Development. 5 (10): 1786–99. doi: 10.1101/gad.5.10.1786 . PMID 1916263.
Hara R, Selby CP, Liu M, Price DH, Sancar A (August 1999). "Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer". The Journal of Biological Chemistry. 274 (35): 24779–86. doi: 10.1074/jbc.274.35.24779 . PMID 10455150.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359 . doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Jiang Y, Liu M, Spencer CA, Price DH (May 2004). "Involvement of transcription termination factor 2 in mitotic repression of transcription elongation". Molecular Cell. 14 (3): 375–85. doi: 10.1016/S1097-2765(04)00234-5 . PMID 15125840.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Jiang Y, Price DH (September 2004). "Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector". Cell Cycle. 3 (9): 1151–3. doi: 10.4161/cc.3.9.1151 . PMID 15467445.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116830 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033222 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9748214-5] Liu M, Xie Z, Price DH (October 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member". The Journal of Biological Chemistry. 273 (40): 25541–4. doi: 10.1074/jbc.273.40.25541 . PMID 9748214.

[entrez-6] 1 2 "Entrez Gene: TTF2 transcription termination factor, RNA polymerase II".

[pmid12927788-7] Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359 . doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.

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TTF2

Contents

Interactions

Related Research Articles

References

Further reading