TTF2

TTF2
Identifiers
Aliases	TTF2 , HuF2, ZGRF6, transcription termination factor, RNA polymerase II, transcription termination factor 2, F2
External IDs	OMIM: 604718; MGI: 1921294; HomoloGene: 37826; GeneCards: TTF2; OMA:TTF2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.1 Start 117,060,326 bp [1] End 117,107,453 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.2 Start 100,938,860 bp [2] End 100,969,663 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve epithelium of colon Achilles tendon bone marrow cells gonad rectum epithelium of nasopharynx appendix mucosa of esophagus testicle Top expressed in hand primitive streak medullary collecting duct epiblast otic vesicle mandibular prominence maxillary prominence hair follicle endothelial cell of lymphatic vessel ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding ATP-dependent activity, acting on DNA zinc ion binding protein binding ATP binding helicase activity hydrolase activity Cellular component spliceosomal complex transcription elongation factor complex nucleus cytoplasm cytosol Biological process DNA-templated transcription, termination termination of RNA polymerase II transcription mRNA processing regulation of transcription, DNA-templated RNA splicing transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8458 74044 Ensembl ENSG00000116830 ENSMUSG00000033222 UniProt Q9UNY4 Q5NC05 RefSeq (mRNA) NM_003594 NM_001013026 RefSeq (protein) NP_003585 NP_001013044 Location (UCSC) Chr 1: 117.06 – 117.11 Mb Chr 3: 100.94 – 100.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene. ^{[5] [6]}

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. ^[6]

Interactions

TTF2 has been shown to interact with CDC5L. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116830 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033222 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu M, Xie Z, Price DH (October 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member". The Journal of Biological Chemistry. 273 (40): 25541–4. doi: 10.1074/jbc.273.40.25541 . PMID   9748214.
6. "Entrez Gene: TTF2 transcription termination factor, RNA polymerase II".
7. Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX   10.1.1.539.8359 . doi:10.1016/S0006-291X(03)01486-4. PMID   12927788.

Further reading

• Girdham CH, Glover DM (October 1991). "Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein". Genes & Development. 5 (10): 1786–99. doi: 10.1101/gad.5.10.1786 . PMID   1916263.
• Hara R, Selby CP, Liu M, Price DH, Sancar A (August 1999). "Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer". The Journal of Biological Chemistry. 274 (35): 24779–86. doi: 10.1074/jbc.274.35.24779 . PMID   10455150.
• Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX   10.1.1.539.8359 . doi:10.1016/S0006-291X(03)01486-4. PMID   12927788.
• Jiang Y, Liu M, Spencer CA, Price DH (May 2004). "Involvement of transcription termination factor 2 in mitotic repression of transcription elongation". Molecular Cell. 14 (3): 375–85. doi: 10.1016/S1097-2765(04)00234-5 . PMID   15125840.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Jiang Y, Price DH (September 2004). "Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector". Cell Cycle. 3 (9): 1151–3. doi: 10.4161/cc.3.9.1151 . PMID   15467445.