TWSG1

Last updated
TWSG1
Identifiers
Aliases TWSG1 , TSG, twisted gastrulation BMP signaling modulator 1
External IDs OMIM: 605049 MGI: 2137520 HomoloGene: 10774 GeneCards: TWSG1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020648

NM_023053

RefSeq (protein)

NP_065699

NP_075540

Location (UCSC) Chr 18: 9.33 – 9.4 Mb Chr 17: 66.23 – 66.26 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene. [5] [6] The protein is a binding protein for bone morphogenetic proteins, similar to Chordin. [7] The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs. [8]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000128791 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024098 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS (Mar 2001). "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling". Nature. 410 (6827): 475–8. doi:10.1038/35068572. PMID   11260715. S2CID   4392365.
  6. "Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)".
  7. Oelgeschläger M, Larraín J, Geissert D, De Robertis EM (2000). "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling". Nature. 405 (6788): 757–63. doi:10.1038/35015500. PMC   2292104 . PMID   10866189.
  8. Graf, D.; Timmons, P. M.; Hitchins, M.; Episkopou, V.; Moore, G.; Ito, T.; Fujiyama, A.; Fisher, A. G.; Merkenschlager, M. (July 2001). "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation". Mammalian Genome. 12 (7): 554–560. doi:10.1007/s0033501-0005-x. ISSN   0938-8990. PMID   11420619. S2CID   36371559 . Retrieved 6 March 2023.

Further reading