TWSG1

TWSG1
Identifiers
Aliases	TWSG1 , TSG, twisted gastrulation BMP signaling modulator 1
External IDs	OMIM: 605049; MGI: 2137520; HomoloGene: 10774; GeneCards: TWSG1; OMA:TWSG1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18p11.22 Start 9,334,767 bp [1] End 9,402,420 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 E1.1|17 35.26 cM Start 66,228,967 bp [2] End 66,258,221 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula cartilage tissue germinal epithelium caput epididymis corpus epididymis tibia tail of epididymis visceral pleura parietal pleura Descending thoracic aorta Top expressed in cumulus cell tail of embryo ascending aorta aortic valve medullary collecting duct genital tubercle corneal stroma efferent ductule right ventricle molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transforming growth factor beta binding Cellular component extracellular region extracellular space Biological process negative regulation of BMP signaling pathway multicellular organism development mesoderm formation cell differentiation forebrain development camera-type eye development salivary gland morphogenesis BMP signaling pathway ossification negative regulation of osteoblast differentiation tissue development positive regulation of BMP signaling pathway negative regulation of cytokine production transforming growth factor beta receptor signaling pathway positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell proliferation hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57045 65960 Ensembl ENSG00000128791 ENSMUSG00000024098 UniProt Q9GZX9 Q9EP52 RefSeq (mRNA) NM_020648 NM_023053 RefSeq (protein) NP_065699 NP_075540 Location (UCSC) Chr 18: 9.33 – 9.4 Mb Chr 17: 66.23 – 66.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene. ^{[5] [6]} The protein is a binding protein for bone morphogenetic proteins, similar to Chordin. ^[7] The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000128791 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024098 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS (Mar 2001). "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling". Nature. 410 (6827): 475–8. doi:10.1038/35068572. PMID   11260715. S2CID   4392365.
6. "Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)".
7. Oelgeschläger M, Larraín J, Geissert D, De Robertis EM (2000). "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling". Nature. 405 (6788): 757–63. Bibcode:2000Natur.405..757O. doi:10.1038/35015500. PMC   2292104 . PMID   10866189.
8. Graf D, Timmons PM, Hitchins M, Episkopou V, Moore G, Ito T, Fujiyama A, Fisher AG, Merkenschlager M (July 2001). "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation". Mammalian Genome. 12 (7): 554–560. doi:10.1007/s0033501-0005-x. ISSN   0938-8990. PMID   11420619. S2CID   36371559.

Further reading

• Graf D, Nethisinghe S, Palmer DB, et al. (2002). "The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development". J. Exp. Med. 196 (2): 163–71. doi:10.1084/jem.20020276. PMC   2193926 . PMID   12119341.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zakin L, De Robertis EM (2004). "Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development". Development. 131 (2): 413–24. doi: 10.1242/dev.00946 . PMID   14681194.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Moreno M, Muñoz R, Aroca F, et al. (2005). "Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway". EMBO J. 24 (7): 1397–405. doi:10.1038/sj.emboj.7600615. PMC   1142540 . PMID   15775969.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Tzachanis D, Li L, Lafuente EM, et al. (2007). "Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes". Blood. 109 (7): 2944–52. doi:10.1182/blood-2006-03-006510. PMC   1852213 . PMID   17164348.