U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel.
U.S. Route 72 (US 72) is an east–west United States highway that travels for 317.811 miles (511.467 km) from southwestern Tennessee, throughout North Mississippi, North Alabama, and southeastern Tennessee. The highway's western terminus is in Memphis, Tennessee and its eastern terminus is in Chattanooga. It is the only U.S. Highway to begin and end in the same state, yet pass through other states in between. Prior to the U.S. Highway system signage being posted in 1926, the entire route was part of the Lee Highway.
Mississippi Highway 5 is a state highway in Benton County, Mississippi, United States. It runs 24.3 mi (39.107 km) from MS 178 in Hickory Flat north to U.S. Route 72 to the south of Michigan City. The route runs through the Holly Springs National Forest for much of its length and passes through Ashland. To the south of Ashland, MS 5 has a concurrency with MS 4. The MS 5 designation was first used by 1932 for an unpaved road between Hickory Flat and the Tennessee border in Michigan City. In 1943, the northern terminus was cut back to US 72. MS 5 was completely paved by 1951 and has retained its current alignment since then.
U.S. Route 51 (US 51), mostly overlapped by the unsigned State Route 3 (SR 3), is a north–south state highway in the U.S. state of Tennessee, that is 135.9 miles (218.71 km) long, completely within West Tennessee. It begins in Shelby County and ends in Obion County. The SR 3 designation is seen largely on mileposts.
State Route 211 (SR 211) is a 17.23-mile (27.73 km) secondary state route in Dyer County, Tennessee, United States, that previously extended north into Obion County. SR 211 is a two-lane highway throughout its length except for a short section in northern Dyersburg.
Interstate 55 (I-55) is part of the Interstate Highway System that runs from LaPlace, Louisiana, to Chicago, Illinois. In the state of Tennessee, the Interstate is located entirely within the state's second-largest city of Memphis, running 12.28 miles (19.76 km) from the Mississippi state line in the Whitehaven neighborhood to the Arkansas border across the Mississippi River. Of the six states that the Interstate passes through, the segment in Tennessee is the shortest, as well as the shortest mainline Interstate segment in Tennessee. I-55 serves a number of neighborhoods and industrial areas in the southwestern portion of Memphis, and also provides access to the Memphis International Airport, the second-busiest cargo airport in the world.
State Route 5 is a 120-mile-long (190 km) north–south state highway in the western part of the U.S. state of Tennessee. Except for the section northwest of Union City, it is entirely concurrent with U.S. Route 45 and US 45W.
State Route 19 or the Tina Turner Highway is a state highway in Haywood and Lauderdale counties in Tennessee, United States. State Route 19 is 42.81 mi (69 km) long.
State Route 15 is a west–east route from Memphis to Monteagle. For much of its route it has an unsigned concurrency with U.S. Route 64. SR 15 does travel through the southern part of all three Grand Divisions of the state: West Tennessee, Middle Tennessee, and East Tennessee.
State Route 57 is an east–west highway that runs from Memphis to the Mississippi state line near Pickwick Dam and Pickwick Landing State Park. Except for in Shelby County and western Fayette County, SR 57 is a two lane road generally with a 55 mph (89 km/h) speed limit. The majority of the road follows the path of the Memphis and Charleston Railroad.
In Tennessee, U.S. Route 412 stretches for 181.93 miles (292.79 km) through the farmland of West Tennessee and the hills of Middle Tennessee, starting at the Missouri state line near Dyersburg and running to an interchange between I-65 and SR 99 in Columbia.
In Tennessee, U.S. Route 64 stretches 404.1 miles (650.3 km) from the Mississippi River in Memphis to the North Carolina state line near Ducktown. The highway, along with US 72, is a major route for travel between Memphis and Chattanooga.
State Route 125 is a north–south state route in southern West Tennessee. It begins north of Silerton at SR 100 and ends at the Tennessee–Mississippi state line, where it continues as Mississippi Highway 15.
U.S. Route 45 (US 45) in Tennessee extends from the Mississippi state line to the Kentucky state line in West Tennessee, passing through the cities of Selmer, Henderson, Jackson, and South Fulton. Between Three Way and South Fulton, the highway is split into US 45W and US 45E.
State Route 60 is a north-south major state route in East Tennessee. It covers 54 miles (87 km) and runs from the Tennessee-Georgia state line in Bradley County to Dayton joining US 27.
State Route 55 is an east–west highway in Middle Tennessee. The road begins at SR 50 in Lynchburg and ends at U.S. Route 70S and SR 380 in McMinnville. The current length is 49.3 mi (79.3 km). SR 55 heads northeast from Lynchburg to Tullahoma as a two-lane road. In Tullahoma, the route runs concurrent with US 41A. From here, SR 55 heads northeast as a multilane highway to Manchester, where it intersects US 41 and Interstate 24 (I-24). The route continues northeast, serving Summitville and Morrison before it reaches McMinnville.
State Route 151 is a state highway in the central portion of the U.S. state of Tennessee.
State Route 122 is a 7.11 mile long east–west state highway in Middle Tennessee. It connects the town of Huntland with the community of Elora. For the majority of its length, SR 122 is known as John Hunter Highway.
State Route 130 is a 51.3-mile-long (82.6 km) east–west state highway in Middle Tennessee.
State Route 138 is a 23.01-mile-long (37.03 km) state highway in West Tennessee, connecting the town of Toone with Interstate 40 (I-40).
MS 7 at Mississippi State Line
US 45 at Jackson 
